Targeting ryanodine receptors to treat human diseases [PDF]
The Journal of Clinical Investigation, 2023 This Review provides an update on ryanodine receptors (RyRs) and their role in human diseases of heart, muscle, and brain. Calcium (Ca2+) is a requisite second messenger in all living organisms. From C.
Andrew R. Marks
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Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM [PDF]
Nature Communications, 2021 Ryanodine Receptors (RyRs) release Ca2+ from the endoplasmic and sarcoplasmic reticulum. Mutations in RyR are linked to malignant hyperthermia (MH), myopathies, and arrhythmias. Here, a collection of cryoEM structures provides insights into the molecular
Kellie A. Woll +2 more
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CaMKII Regulation of Cardiac Ryanodine Receptors and Inositol Triphosphate Receptors
Frontiers in Pharmacology, 2014 Ryanodine receptors (RyRs) and inositol triphosphate receptors (InsP3Rs) are structurally related intracellular calcium release channels that participate in multiple primary or secondary amplified Ca2+ signals, triggering muscle contraction and ...
Emmanuel eCamors, Hector H Valdivia
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Potential physiological and pathological roles for axonal ryanodine receptors [PDF]
Neural Regeneration Research, 2023 Clinical disability following trauma or disease to the spinal cord often involves the loss of vital white matter elements including axons and glia.
David P Stirling
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Astrocyte ryanodine receptors facilitate gliotransmission and astroglial modulation of synaptic plasticity [PDF]
Frontiers in Cellular NeuroscienceIntracellular Ca2+-signaling in astrocytes is instrumental for their brain “housekeeping” role and astroglial control of synaptic plasticity. An important source for elevating the cytosolic Ca2+ level in astrocytes is a release from endoplasmic reticulum
Ulyana Lalo, Yuriy Pankratov
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Skeletal Muscle, 2011 Excitation-contraction coupling involves the faithful conversion of electrical stimuli to mechanical shortening in striated muscle cells, enabled by the ubiquitous second messenger, calcium.
Capes E Michelle +2 more
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An updated view of the structural basis for dihydropyridine receptors-ryanodine receptors direct molecular interaction in skeletal muscle [PDF]
European Journal of Translational MyologyThis presentation reviews images of electron micrographs from various skeletal muscles identifying a consistent association of diydropyridine receptors (DHPR) tetrads with alternate ryanodine receptors.
Clara Franzini-Armstrong
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True Molecular Scale Visualization of Variable Clustering Properties of Ryanodine Receptors
Cell Reports, 2018 Summary: Signaling nanodomains rely on spatial organization of proteins to allow controlled intracellular signaling. Examples include calcium release sites of cardiomyocytes where ryanodine receptors (RyRs) are clustered with their molecular partners ...
Isuru Jayasinghe +8 more
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Identification of a dihydropyridine scaffold that blocks ryanodine receptors [PDF]
iScience, 2022 Summary: Ryanodine receptors (RyRs) are large, intracellular ion channels that control Ca2+ release from the sarco/endoplasmic reticulum. Dysregulation of RyRs in skeletal muscle, heart, and brain has been implicated in various muscle pathologies ...
Gihan S. Gunaratne +10 more
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Calcium-induced calcium release and type 3 ryanodine receptors modulate the slow afterhyperpolarising current, sIAHP, and its potentiation in hippocampal pyramidal neurons. [PDF]
PLoS ONE, 2020 The slow afterhyperpolarising current, sIAHP, is a Ca2+-dependent current that plays an important role in the late phase of spike frequency adaptation.
Angelo Tedoldi +5 more
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