Results 1 to 10 of about 2,688,953 (298)

Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders [PDF]

Nature Communications
Heart failure, the leading cause of mortality and morbidity in the developed world, is characterized by cardiac ryanodine receptor 2 channels that are hyperphosphorylated, oxidized, and depleted of the stabilizing subunit calstabin-2.
Marco C. Miotto, Steven Reiken, Anetta Wronska, Qi Yuan, Haikel Dridi, Yang Liu, Gunnar Weninger, Carl Tchagou, Andrew R. Marks   +8 more
doaj   +3 more sources

Aging Effects of Caenorhabditis elegans Ryanodine Receptor Variants Corresponding to Human Myopathic Mutations [PDF]

G3: Genes, Genomes, Genetics, 2017
Delaying the decline in skeletal muscle function will be critical to better maintenance of an active lifestyle in old age. The skeletal muscle ryanodine receptor, the major intracellular membrane channel through which calcium ions pass to elicit muscle ...
Katie Nicoll Baines, Célia Ferreira, Philip M. Hopkins, Marie-Anne Shaw, Ian A. Hope   +4 more
doaj   +4 more sources

Muscle-specific Ryanodine receptor 1 properties underlie limb-girdle muscular dystrophy 2B/R2 progression [PDF]

Nature Communications
Ryanodine receptor 1 Ca2+ leak is a signal in skeletal muscle, but chronic leak can underlie pathology. Here we show that in healthy male mouse, limb-girdle muscle presents higher sympathetic input, elevated ryanodine receptor 1 basal phosphorylation ...
Aldo Meizoso-Huesca, Cedric R. Lamboley, James R. Krycer, Mark P. Hodson, James E. Hudson, Bradley S. Launikonis   +5 more
doaj   +2 more sources

Cryo-EM investigation of ryanodine receptor type 3 [PDF]

Nature Communications
Ryanodine Receptor isoform 3 (RyR3) is a large ion channel found in the endoplasmic reticulum membrane of many different cell types. Within the hippocampal region of the brain, it is found in dendritic spines and regulates synaptic plasticity.
Yu Seby Chen, Maricela Garcia-Castañeda, Maria Charalambous, Daniela Rossi, Vincenzo Sorrentino, Filip Van Petegem   +5 more
doaj   +2 more sources

Disparate molecular mechanisms in cardiac ryanodine receptor channelopathies [PDF]

Frontiers in Molecular Biosciences
AimsMutations in the cardiac ryanodine receptor (RyR2) are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT). This study investigates the underlying molecular mechanisms for CPVT mutations within the RyR2 N-terminus domain (NTD)
Yadan Zhang, Monika Seidel, Camille Rabesahala de Meritens, Astrid Beckmann, Syeda Ahmed, Melanie Hurtz, F. Anthony Lai, Esther Zorio, Esther Zorio, Esther Zorio, Esther Zorio, Dimitris Parthimos, Spyros Zissimopoulos   +12 more
doaj   +2 more sources

Cardiac ryanodine receptor calcium release deficiency syndrome

Science Translational Medicine, 2021
Clinical and basic studies shed light on the mechanism, diagnosis, and treatment of cardiac ryanodine receptor Ca2+ release deficiency syndrome. Calcium and cardiac arrhythmia Calcium signaling couples cardiac electrical excitation and contraction and is
Bo Sun, Jinjing Yao, Mingke Ni, Jinhong Wei, Xiaowei Zhong, Wenting Guo, Lin Zhang, Ruiwu Wang, D. Belke, Yong-Xiang Chen, K. Lieve, A. K. Broendberg, T. Roston, I. Blankoff, J. Kammeraad, Johannes C. von Alvensleben, J. Lazarte, Alexander Vallmitjana, Loryn J. Bohne, R. Rose, R. Benítez, L. Hove-Madsen, C. Napolitano, R. Hegele, M. Fill, S. Sanatani, A. Wilde, Jason D. Roberts, S. Priori, H. Jensen, S. Chen   +30 more
semanticscholar   +1 more source

Ryanodine receptors [PDF]

Skeletal Muscle, 2011
Abstract Excitation-contraction coupling involves the faithful conversion of electrical stimuli to mechanical shortening in striated muscle cells, enabled by the ubiquitous second messenger, calcium. Crucial to this process are ryanodine receptors (RyRs), the sentinels of massive intracellular calcium stores contained within the sarcoplasmic ...
Capes E Michelle, Loaiza Randall, Valdivia Héctor H   +2 more
openaire   +3 more sources

Ryanodine Receptors Selectively Interact with L Type Calcium Channels in Mouse Taste Cells. [PDF]

PLoS ONE, 2013
INTRODUCTION:WE REPORTED THAT RYANODINE RECEPTORS ARE EXPRESSED IN TWO DIFFERENT TYPES OF MAMMALIAN PERIPHERAL TASTE RECEPTOR CELLS: Type II and Type III cells. Type II cells lack voltage-gated calcium channels (VGCCs) and chemical synapses.
Michelle R Rebello, Amanda B Maliphol, Kathryn F Medler   +2 more
doaj   +1 more source

A basal level of γ-linolenic acid depletes Ca2+ stores and induces endoplasmic reticulum and oxidative stresses to cause death of breast cancer BT-474 cells

Chinese Journal of Physiology, 2021
Gamma-linolenic acid (GLA), a natural fatty acid obtained from oils of various vegetables and seeds, has been demonstrated as an anticancer agent. In this work, we investigated the anticancer effects of GLA on breast cancer BT-474 cells.
Cing-Yu Chen, Cheng-Hsun Wu, King-Chuen Wu, Lian-Ru Shiao, Chin-Min Chuang, Yuk-Man Leung, Louis W C Chow   +6 more
doaj   +1 more source

Ryanodine Receptor Patents [PDF]

Recent Patents on Biotechnology, 2012
Research over the past two decades has implicated dysfunction of the ryanodine receptor (RyR), a Ca(2+) release channel on the sarcoplasmic reticulum (SR) required for excitation-contraction (EC) coupling, in the pathogenesis of cardiac and skeletal myopathies.
Alexander, Kushnir, Andrew R, Marks
openaire   +2 more sources