Results 1 to 10 of about 31,472 (217)

Muscle-specific Ryanodine receptor 1 properties underlie limb-girdle muscular dystrophy 2B/R2 progression [PDF]

Nature Communications
Ryanodine receptor 1 Ca2+ leak is a signal in skeletal muscle, but chronic leak can underlie pathology. Here we show that in healthy male mouse, limb-girdle muscle presents higher sympathetic input, elevated ryanodine receptor 1 basal phosphorylation ...
Aldo Meizoso-Huesca, Cedric R. Lamboley, James R. Krycer, Mark P. Hodson, James E. Hudson, Bradley S. Launikonis   +5 more
doaj   +2 more sources

Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders [PDF]

Nature Communications
Heart failure, the leading cause of mortality and morbidity in the developed world, is characterized by cardiac ryanodine receptor 2 channels that are hyperphosphorylated, oxidized, and depleted of the stabilizing subunit calstabin-2.
Marco C. Miotto, Steven Reiken, Anetta Wronska, Qi Yuan, Haikel Dridi, Yang Liu, Gunnar Weninger, Carl Tchagou, Andrew R. Marks   +8 more
doaj   +2 more sources

Cryo-EM investigation of ryanodine receptor type 3 [PDF]

Nature Communications
Ryanodine Receptor isoform 3 (RyR3) is a large ion channel found in the endoplasmic reticulum membrane of many different cell types. Within the hippocampal region of the brain, it is found in dendritic spines and regulates synaptic plasticity.
Yu Seby Chen, Maricela Garcia-Castañeda, Maria Charalambous, Daniela Rossi, Vincenzo Sorrentino, Filip Van Petegem   +5 more
doaj   +2 more sources

Disparate molecular mechanisms in cardiac ryanodine receptor channelopathies [PDF]

Frontiers in Molecular Biosciences
AimsMutations in the cardiac ryanodine receptor (RyR2) are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT). This study investigates the underlying molecular mechanisms for CPVT mutations within the RyR2 N-terminus domain (NTD)
Yadan Zhang, Monika Seidel, Camille Rabesahala de Meritens, Astrid Beckmann, Syeda Ahmed, Melanie Hurtz, F. Anthony Lai, Esther Zorio, Esther Zorio, Esther Zorio, Esther Zorio, Dimitris Parthimos, Spyros Zissimopoulos   +12 more
doaj   +2 more sources

Ryanodine receptors [PDF]

Skeletal Muscle, 2011
Abstract Excitation-contraction coupling involves the faithful conversion of electrical stimuli to mechanical shortening in striated muscle cells, enabled by the ubiquitous second messenger, calcium. Crucial to this process are ryanodine receptors (RyRs), the sentinels of massive intracellular calcium stores contained within the sarcoplasmic ...
Capes E Michelle, Loaiza Randall, Valdivia Héctor H   +2 more
openaire   +3 more sources

Ryanodine Receptors Selectively Interact with L Type Calcium Channels in Mouse Taste Cells. [PDF]

PLoS ONE, 2013
INTRODUCTION:WE REPORTED THAT RYANODINE RECEPTORS ARE EXPRESSED IN TWO DIFFERENT TYPES OF MAMMALIAN PERIPHERAL TASTE RECEPTOR CELLS: Type II and Type III cells. Type II cells lack voltage-gated calcium channels (VGCCs) and chemical synapses.
Michelle R Rebello, Amanda B Maliphol, Kathryn F Medler   +2 more
doaj   +1 more source

A basal level of γ-linolenic acid depletes Ca2+ stores and induces endoplasmic reticulum and oxidative stresses to cause death of breast cancer BT-474 cells

Chinese Journal of Physiology, 2021
Gamma-linolenic acid (GLA), a natural fatty acid obtained from oils of various vegetables and seeds, has been demonstrated as an anticancer agent. In this work, we investigated the anticancer effects of GLA on breast cancer BT-474 cells.
Cing-Yu Chen, Cheng-Hsun Wu, King-Chuen Wu, Lian-Ru Shiao, Chin-Min Chuang, Yuk-Man Leung, Louis W C Chow   +6 more
doaj   +1 more source

Ryanodine Receptors in Liver [PDF]

Journal of Biological Chemistry, 2006
The ryanodine receptor has been mainly regarded as the Ca2+ release channel from sarcoplasmic reticulum controlling skeletal and cardiac muscle contraction. However, many studies have shown that it is widely expressed, with functions not restricted to muscular contraction. This study examined whether ryanodine receptor plays a role in calcium signaling
Nicola, Pierobon, Dominique C, Renard-Rooney, Lawrence D, Gaspers, Andrew P, Thomas   +3 more
openaire   +2 more sources

Structural Insight Into Ryanodine Receptor Channelopathies

Frontiers in Pharmacology, 2022
The ryanodine receptors (RyRs) are large cation-selective ligand-gated channels that are expressed in the sarcoplasmic reticulum (SR) membrane. They mediate the controlled release of Ca2+ from SR and play an important role in many cellular processes. The
Hadiatullah Hadiatullah, Hadiatullah Hadiatullah, Zhao He, Zhao He, Zhiguang Yuchi, Zhiguang Yuchi   +5 more
doaj   +1 more source

Ryanodine Receptor Patents [PDF]

Recent Patents on Biotechnology, 2012
Research over the past two decades has implicated dysfunction of the ryanodine receptor (RyR), a Ca(2+) release channel on the sarcoplasmic reticulum (SR) required for excitation-contraction (EC) coupling, in the pathogenesis of cardiac and skeletal myopathies.
Alexander, Kushnir, Andrew R, Marks
openaire   +2 more sources