Results 1 to 10 of about 28,867 (291)

Single channel activity of the ryanodine receptor calcium release channel is modulated by FK‐506

FEBS Letters, 1994
The immunosuppressant drug FK‐506 (3–20 μM) increased the open probability of ryanodine receptor calcium release channels, formed by incorporation of terminal cisternae vesicles from rabbit skeletal muscle into lipid bilayers, with cis (cytoplasmic) calcium concentrations between 10−7 M and 10−3 M.
Ahern, Gerard P., Junankar, Pauline R., Dulhunty, Angela F.   +2 more
openaire   +4 more sources

Structural insights into transmembrane helix S0 facilitated RyR1 channel gating by Ca2+/ATP

Nature Communications
The type-1 ryanodine receptor (RyR1) is an intracellular calcium release channel for skeletal muscle excitation-contraction coupling. Previous structural studies showed that the RyR1 activity is modulated by the exogenous regulators including caffeine ...
Risheng Wei, Qiang Chen, Lei Zhang, Congcong Liu, Chuang Liu, Chang-Cheng Yin, Hongli Hu   +6 more
doaj   +1 more source

Modality specific roles for metabotropic GABAergic signaling and calcium induced calcium release mechanisms in regulating cold nociception

Frontiers in Molecular Neuroscience, 2022
Calcium (Ca2+) plays a pivotal role in modulating neuronal-mediated responses to modality-specific sensory stimuli. Recent studies in Drosophila reveal class III (CIII) multidendritic (md) sensory neurons function as multimodal sensors regulating ...
Atit A. Patel, Akira Sakurai, Nathaniel J. Himmel, Daniel N. Cox   +3 more
doaj   +1 more source

Genetic ablation of ryanodine receptor 2 phosphorylation at Ser‐2808 aggravates Ca 2+ ‐dependent cardiomyopathy by exacerbating diastolic Ca 2+ release [PDF]

, 2014
Phosphorylation of the cardiac ryanodine receptor (RyR2) by protein kinase A (PKA) at Ser‐2808 is suggested to mediate the physiological ‘fight or flight’ response and contribute to heart failure by rendering the sarcoplasmic reticulum (SR) leaky for Ca ...
Gyorke, Sandor, Ho, Hsiang‐ting, Knollmann, Bjorn C., Liu, Bin, Lou, Qing, Valdivia, Carmen R., Valdivia, Hector H., Velez‐cortes, Florencia   +7 more
core   +1 more source

IP₃R-Mediated Calcium Release Promotes Ferroptotic Death in SH-SY5Y Neuroblastoma Cells

Antioxidants
Ferroptosis is an iron-dependent cell death pathway that involves the depletion of intracellular glutathione (GSH) levels and iron-mediated lipid peroxidation. Ferroptosis is experimentally caused by the inhibition of the cystine/glutamate antiporter xCT,
Joaquín Campos, Silvia Gleitze, Cecilia Hidalgo, Marco T. Núñez   +3 more
doaj   +1 more source

Characterization of Transepithelial Potential Oscillations in the \u3cem\u3eDrosophila\u3c/em\u3e Malpighian Tubule [PDF]

, 2001
The Malpighian tubule of Drosophila melanogaster is a useful model system for studying the regulation of epithelial ion transport. In acutely isolated tubules, the transepithelial potential (TEP) undergoes large oscillations in amplitude with a period of
Blumenthal, Edward M
core   +1 more source

Exploiting Peptidomimetics to Synthesize Compounds That Activate Ryanodine Receptor Calcium Release Channels

ChemMedChem, 2018
AbstractRyanodine receptor (RyR) Ca2+‐release channels are essential for contraction in skeletal and cardiac muscle and are prime targets for modification of contraction in disorders that affect either the skeletal or heart musculature. We designed and synthesized a number of compounds with structures based on a naturally occurring peptide (A peptides)
Ken Robinson, Christopher J. Easton, Angela F. Dulhunty, Marco G. Casarotto   +3 more
openaire   +4 more sources

Molecular genetic analysis for malignant hyperthermia : a thesis presented to Massey University in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry [PDF]

, 2004
Malignant hyperthermia (MH) is a rare pharmacogenetic disorder in humans caused by inhalational general anaesthetics and depolarising muscle relaxants. An MH reaction shows abnormal calcium homeostasis in skeletal muscle leading to a hypermetabolic state
Sato, Keisaku
core  

Targeting RyR Activity Boosts Antisense Exon 44 and 45 Skipping in Human DMD Skeletal or Cardiac Muscle Culture Models. [PDF]

, 2019
Systemic delivery of antisense oligonucleotides (AO) for DMD exon skipping has proven effective for reframing DMD mRNA, rescuing dystrophin expression, and slowing disease progression in animal models.
Barthélémy, Florian, Douine, Emilie D, Hsu, Christopher, Marcantonio, Eugene E, Miceli, M Carrie, Nelson, Stanley F, Wang, Richard T   +6 more
core   +1 more source

Congenital muscle disorders with cores: the ryanodine receptor calcium channel paradigm [PDF]

, 2008
Dysregulation of calcium signals because of defects of the skeletal muscle sarcoplasmic reticulum calcium release channel (ryanodine receptor; RyR1) is causative of several congenital muscle disorders including malignant hyperthermia (MH; MIM #145600 ...
Jungbluth, Heinz, Muntoni, Francesco, Treves, Susan, Zorzato, Francesco   +3 more
core   +1 more source