Results 1 to 10 of about 17,120 (211)

Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling [version 1; referees: 4 approved] [PDF]

F1000Research, 2018
The ryanodine receptor calcium release channel is central to cytoplasmic Ca2+ signalling in skeletal muscle, the heart, and many other tissues, including the central nervous system, lymphocytes, stomach, kidney, adrenal glands, ovaries, testes, thymus ...
Angela F. Dulhunty, Nicole A. Beard, Marco G. Casarotto   +2 more
doaj   +3 more sources

Calcium release deficiency syndrome: an emerging ryanodinopathy [PDF]

Frontiers in Molecular Biosciences
The cardiac ryanodine receptor (RyR2) is a critical calcium release channel essential for normal cardiac contraction. Dysregulation of RyR2 function is a key pathogenic factor in various cardiac diseases, notably arrhythmias and heart failure.
Kaiyang Gao, Lan Tao, Xiaoqing Li, Baihe Li, Nike Li, Jinhong Wei   +5 more
doaj   +2 more sources

Single channel activity of the ryanodine receptor calcium release channel is modulated by FK-506

FEBS Letters, 1994
The immunosuppressant drug FK‐506 (3–20 μM) increased the open probability of ryanodine receptor calcium release channels, formed by incorporation of terminal cisternae vesicles from rabbit skeletal muscle into lipid bilayers, with cis (cytoplasmic) calcium concentrations between 10−7 M and 10−3 M.
Angela Dulhunty
exaly   +3 more sources

Nitric oxide-induced calcium release: activation of type 1 ryanodine receptor, a calcium release channel, through non-enzymatic posttranslational modification by nitric oxide

Frontiers in Endocrinology, 2013
Nitric oxide (NO) is a typical gaseous messenger involved in a wide range of biological processes. In our classical knowledge, effects of NO are largely achieved by activation of soluble guanylyl cyclase to form cyclic guanosine-3’, 5’-monophosphate ...
Sho eKakizawa
doaj   +3 more sources

Ryanodine receptor calcium release channels in trophoblasts and their role in cell migration [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2022
Trophoblasts are specialized epithelial cells of the placenta that are involved in invasion, communication and the exchange of materials between the mother and fetus. Cytoplasmic Ca2+ ([Ca2+]c) plays critical roles in regulating such processes in other cell types, but relatively little is known about the mechanisms that control this second messenger in
Zheng, L, Lindsay, A, McSweeney, K, Aplin, J, Forbes, K, Smith, S, Tunwell, R, Mackrill, JJ   +7 more
openaire   +4 more sources

CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles

eLife, 2023
Activation of voltage-gated calcium channels at presynaptic terminals leads to local increases in calcium and the fusion of synaptic vesicles containing neurotransmitter.
Brian D Mueller, Sean A Merrill, Shigeki Watanabe, Ping Liu, Longgang Niu, Anish Singh, Pablo Maldonado-Catala, Alex Cherry, Matthew S Rich, Malan Silva, Andres Villu Maricq, Zhao-Wen Wang, Erik M Jorgensen   +12 more
doaj   +1 more source

Calcium-release channels: structure and function of IP₃ receptors and ryanodine receptors [PDF]

Physiological Reviews, 2022
Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors (RyRs) and inositol-1,4,5-trisphosphate receptors (IP3Rs), are evolutionarily related and are both activated by cytosolic Ca2+.
Kellie A, Woll, Filip, Van Petegem
openaire   +2 more sources

Magnesium Ions Moderate Calcium-Induced Calcium Release in Cardiac Calcium Release Sites by Binding to Ryanodine Receptor Activation and Inhibition Sites

Frontiers in Physiology, 2022
Ryanodine receptor channels at calcium release sites of cardiac myocytes operate on the principle of calcium-induced calcium release. In vitro experiments revealed competition of Ca2+ and Mg2+ in the activation of ryanodine receptors (RyRs) as well as ...
Bogdan Iaparov, Iuliia Baglaeva, Ivan Zahradník, Alexandra Zahradníková   +3 more
doaj   +1 more source

“Ryanopathies” and RyR2 dysfunctions: can we further decipher them using in vitro human disease models?

Cell Death and Disease, 2021
The regulation of intracellular calcium (Ca2+) homeostasis is fundamental to maintain normal functions in many cell types. The ryanodine receptor (RyR), the largest intracellular calcium release channel located on the sarco/endoplasmic reticulum (SR/ER),
Yvonne Sleiman, Alain Lacampagne, Albano C. Meli   +2 more
doaj   +1 more source

Single Amino Acid Changes in the Ryanodine Receptor in the Human Population Have Effects In Vivo on Caenorhabditis elegans Neuro-Muscular Function

Frontiers in Genetics, 2020
The ryanodine receptor mediates intracellular calcium ion release with excitation of nerve and muscle cells. Ryanodine receptor missense variants cause a number of myopathologies, such as malignant hyperthermia, and have been linked with various ...
Brittany Graham, Marie-Anne Shaw, Ian A. Hope   +2 more
doaj   +1 more source