Results 31 to 40 of about 4,095,708 (243)

Study of calcium sparks in skeletal and smooth muscle cells in normal and pathological conditions [PDF]

, 2016
mTOR signaling influence a wide range of cellular process including protein synthesis (Iadevaia et al., 2012; Ma and Blenis, 2009; Thoreen et al., 2012), lipids synthesis (Lamming and Sabatini, 2013), transcription (Dibble and Manning, 2013; Vazquez ...
López, Rubén
core   +1 more source

FGF23 promotes atrial fibrillation susceptibility through ETV1-dependent sodium channel regulation and calcium handling abnormalities. [PDF]

Exp Physiol
Abstract Fibroblast growth factor 23 (FGF23) is closely associated with atrial fibrillation (AF), yet whether it modulates sodium and calcium currents in atrial myocytes remains unclear. ETV1, a key transcription factor regulating atrial electrical conduction, might also be involved in FGF23‐mediated AF.
Yu Q, Zeng L, Chen Z, Lin Z, Wang C, Wang L, Fu H, Zhang J.   +7 more
europepmc   +2 more sources

First Phase of Glucose-Stimulated Insulin Secretion From MIN 6 Cells Does Not Always Require Extracellular Calcium Influx

Journal of Pharmacological Sciences, 2006
.: To demonstrate an involvement of ATP-sensitive potassium (KATP) channel-independent pathways in the first phase of glucose-stimulated insulin secretion (GSIS) from pancreatic β cells, the time course of GSIS from MIN6 cells was analyzed at 30-s sample
Shigeto Makoto, Katsura Masashi, Matsuda Masafumi, Ohkuma Seitaro, Kaku Kohei   +4 more
doaj   +1 more source

Calcium Influx and Release Cooperatively Regulate AChR Patterning and Motor Axon Outgrowth during Neuromuscular Junction Formation

Cell Reports, 2018
Summary: Formation of synapses between motor neurons and muscles is initiated by clustering of acetylcholine receptors (AChRs) in the center of muscle fibers prior to nerve arrival. This AChR patterning is considered to be critically dependent on calcium
Mehmet Mahsum Kaplan, Nasreen Sultana, Ariane Benedetti, Gerald J. Obermair, Nina F. Linde, Symeon Papadopoulos, Anamika Dayal, Manfred Grabner, Bernhard E. Flucher   +8 more
doaj   +1 more source

Physiology and Pharmacology of Ryanodine Receptor Calcium Release Channels

, 2017
Ryanodine receptor (RyR) ion channels are essential for skeletal and cardiac muscle function. Their knockout leads to perinatal death from respiratory and cardiac failure. Acquired changes or mutations in the protein cause debilitating skeletal myopathy and cardiac arrhythmia which can be deadly. Knowledge of the pharmacology of RyR channels is central
Dulhunty, Angela, Board, Philip, Beard, Nicole, Casarotto, Marco   +3 more
openaire   +3 more sources

Calcium Ion as a Second Messenger With Special Reference to Excitation-Contraction Coupling

Journal of Pharmacological Sciences, 2006
.: Calcium ion (Ca2+) plays an important role in stimulus-response reactions of cells as a second messenger. This is done by keeping cytoplasmic Ca2+ concentration low at rest and by mobilizing Ca2+ in response to stimulus, which in turn activates the ...
Makoto Endo
doaj   +1 more source

Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density [PDF]

, 2011
Rationale: In ventricular myocytes of large mammals, not all ryanodine receptor (RyR) clusters are associated with T-tubules (TTs); this fraction increases with cellular remodeling after myocardial infarction (MI).
MacQuaide, N., Bito, Virginie, Smith, G.L., Macquaide, Niall, Biesmans, L., Godfrey L. Smith, Frank R Heinzel, Sipido, Karin R., Karin R Sipido, Smith, Godfrey L., Rota, M., Heinzel, F.R., Godfrey L Smith, Bito, V., Sipido, K.R., Heinzel, Frank R., Niall Macquaide, Liesbeth Biesmans, Biesmans, Liesbeth, Virginie Bito, Frank R. Heinzel, Karin R. Sipido   +21 more
core   +2 more sources

Adenine dinucleotide second messengers and T-lymphocyte calcium signaling

Frontiers in Immunology, 2013
Calcium signaling is a universal signal transduction mechanism in animal and plant cells. In mammalian T-lymphocytes calcium signaling is essential for activation and re-activation and thus important for a functional immune response.
Insa MA Ernst, Ralf eFliegert, Andreas H Guse   +2 more
doaj   +1 more source

Beneficial effects of dantrolene in the treatment of rhabdomyolysis as a potential late complication associated with COVID-19: a case report

European Journal of Medical Research, 2021
Background Patients with severe COVID-19 have disorders of the respiratory, cardiovascular, coagulation, skeletal muscle, and central nervous systems. These systemic failures may be associated with cytokine release syndrome, characterized by hyperpyrexia,
Nobutaka Chiba, Masakazu Matsuzaki, Takayuki Mawatari, Minori Mizuochi, Atsushi Sakurai, Kosaku Kinoshita   +5 more
doaj   +1 more source

Molecular, Subcellular, and Arrhythmogenic Mechanisms in Genetic RyR2 Disease

Biomolecules, 2022
The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple functional domains with specific roles, and four of these RyR2 protomers are ...
Ewan Douglas Fowler, Spyros Zissimopoulos   +1 more
doaj   +1 more source