Results 51 to 60 of about 17,120 (211)

Contribution of NAADP to Glutamate-Evoked Changes in Ca2+ Homeostasis in Mouse Hippocampal Neurons

Frontiers in Cell and Developmental Biology, 2020
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that evokes calcium release from intracellular organelles by the engagement of calcium release channels, including members of the Transient Receptor Potential (TRP) family, such ...
Julia Hermann, Melanie Bender, Dagmar Schumacher, Dagmar Schumacher, Marcel S. Woo, Artem Shaposhnykov, Sina C. Rosenkranz, Vladimir Kuryshev, Vladimir Kuryshev, Chris Meier, Andreas H. Guse, Manuel A. Friese, Marc Freichel, Marc Freichel, Volodymyr Tsvilovskyy, Volodymyr Tsvilovskyy   +15 more
doaj   +1 more source

Dependency of calcium alternans on ryanodine receptor refractoriness. [PDF]

PLoS ONE, 2013
BACKGROUND: Rapid pacing rates induce alternations in the cytosolic calcium concentration caused by fluctuations in calcium released from the sarcoplasmic reticulum (SR).
Enric Alvarez-Lacalle, Inma R Cantalapiedra, Angelina Peñaranda, Juan Cinca, Leif Hove-Madsen, Blas Echebarria   +5 more
doaj   +1 more source

Isolation and characterization of a gene for a ryanodine receptor/calcium release channel in Drosophila melanogaster [PDF]

FEBS Letters, 1994
The nucleotide sequence of a 25.7 kilobase Drosophila melanogaster genomic DNA segment containing a gene for a ryanodine receptor/calcium release channel homologue has been determined. Computer analysis and partial cDNA cloning revealed 26 exons comprising the protein‐coding sequence in this gene.
Takeshima, Hiroshi, Nishi, Miyuki, Iwabe, Naoyuki, Miyata, Takashi, Hosoya, Toshihiko, Masai, Ichiro, Hotta, Yoshiki   +6 more
openaire   +2 more sources

Bruton tyrosine kinase inhibitors and cardiovascular adverse events

British Journal of Pharmacology, EarlyView.
Abstract Bruton tyrosine kinase inhibitors (BTKi) have transformed the management of chronic lymphocytic leukaemia and other B‐cell malignancies, yet their therapeutic benefit is tempered by clinically relevant cardiovascular toxicities (predominantly atrial fibrillation, hypertension, bleeding and ventricular arrhythmias).
Massimiliano Camilli, Cristina Madaudo, Emanuela Salvatorelli, Giorgio Minotti, Pierantonio Menna   +4 more
wiley   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Structural insights into transmembrane helix S0 facilitated RyR1 channel gating by Ca2+/ATP

Nature Communications
The type-1 ryanodine receptor (RyR1) is an intracellular calcium release channel for skeletal muscle excitation-contraction coupling. Previous structural studies showed that the RyR1 activity is modulated by the exogenous regulators including caffeine ...
Risheng Wei, Qiang Chen, Lei Zhang, Congcong Liu, Chuang Liu, Chang-Cheng Yin, Hongli Hu   +6 more
doaj   +1 more source

Ryanodine receptor/calcium release channel conformations as reflected in the different effects of propranolol on its ryanodine binding and channel activity [PDF]

Biochemical Journal, 1996
1. Propranolol, a β-blocker, inhibited or stimulated ryanodine binding to both the membrane-bound and purified ryanodine receptor (RyR) depending on the assay conditions. At high NaCl concentrations, propranolol increased the number of ryanodine-binding sites (Bmax) with no effect on the binding affinity.
S, Zchut, W, Feng, V, Shoshan-Barmatz
openaire   +2 more sources

Long‐Term Serial Exercise Stress Testing in Catecholaminergic Polymorphic Ventricular Tachycardia on Beta‐Blocker and Flecainide Therapy

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Introduction Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially life‐threatening arrhythmic disorder typically treated with beta‐blockers and, occasionally, with flecainide. Methods All patients underwent genetic testing, electrocardiogram, echocardiogram, and exercise testing.
Fernando Wangüemert‐Perez, German Ostos‐Cañero, Marta Wangüemert‐Guerra, Carlos Acosta‐Materan, Aridane Cárdenes‐león, Eduardo Caballero‐Dorta, Kevin Pérez‐Rodríguez, Ramón Brugada, Josep Brugada, Efrén Martínez‐Quintana   +9 more
wiley   +1 more source

IP₃R-Mediated Calcium Release Promotes Ferroptotic Death in SH-SY5Y Neuroblastoma Cells

Antioxidants
Ferroptosis is an iron-dependent cell death pathway that involves the depletion of intracellular glutathione (GSH) levels and iron-mediated lipid peroxidation. Ferroptosis is experimentally caused by the inhibition of the cystine/glutamate antiporter xCT,
Joaquín Campos, Silvia Gleitze, Cecilia Hidalgo, Marco T. Núñez   +3 more
doaj   +1 more source

RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation

Acta Neuropathologica Communications, 2021
The type 1 ryanodine receptor (RyR1) is an intracellular calcium (Ca2+) release channel on the sarcoplasmic/endoplasmic reticulum that is required for skeletal muscle contraction.
Qi Yuan, Haikel Dridi, Oliver B. Clarke, Steven Reiken, Zephan Melville, Anetta Wronska, Alexander Kushnir, Ran Zalk, Leah Sittenfeld, Andrew R. Marks   +9 more
doaj   +1 more source