Results 51 to 60 of about 4,095,708 (243)
FKBP12 Depletion Leads to Loss of Sarcoplasmic Reticulum Ca2+ Stores in Rat Vas Deferens
Journal of Pharmacological Sciences, 2009 The immunophilin 12-kDa FK506 binding protein (FKBP12) stabilizes intracellular Ca2+ release channel (CRC) activity in different tissues. In this work, the presence of FKBP12 in rat vas deferens (RVD) and its possible contribution to RVD function was ...
Christianne B.V. Scaramello +4 more
doaj +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley +1 more source
The N-Terminal Region of the Ryanodine Receptor Affects Channel Activation
Frontiers in Physiology, 2017 Mutations in the cardiac ryanodine receptor (RyR2), the ion channel responsible for release of calcium ions from intracellular stores into cytoplasm, are the cause of several inherited cardiac arrhythmias.
Andrea Faltinova +6 more
doaj +1 more source
Insect Science, EarlyView.• First demonstration of functional RNAi in the beet leafhopper, Neoaliturus tenellus, using both dsRNA microinjection and star polycation nanoparticle‐mediated topical spray delivery.•Microinjection achieved over 90% knockdown of Gus and Pum3, revealing gene‐specific fitness effects on survival and fecundity in beet leafhopper.•Nanoparticle‐mediated ...
Jinlong Han +8 more
wiley +1 more source
An investigation of NAADP-dependent Ca²⁺ signalling mechanisms in arterial smooth muscle [PDF]
, 2007 Previous investigations on pulmonary artery smooth muscle cells have shown that nicotinic acid adenine dinucleotide diphosphate (NAADP) evokes highly localised intracellular Ca²⁺ bursts by mobilising thapsigargin-insensitive Ca²⁺ stores.
Kinnear, Nicholas P.
core +2 more sources
Construction of calcium release sites in cardiac myocytes
Frontiers in Physiology, 2012 Local character of calcium release in cardiac myocytes, as defined by confocal recordings of calcium sparks, implies independent activation of individual calcium release sites based on ryanodine receptor (RyR) channel recruitment.
Alexandra eZahradnikova +2 more
doaj +1 more source
Compartmentalisation in cAMP signalling: A phase separation perspective
British Journal of Pharmacology, EarlyView.Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley +1 more source
Functional characterization of orbicularis oculi and extraocular muscles [PDF]
, 2016 The orbicularis oculi are the sphincter muscles of the eyelids and are involved in modulating facial expression. They differ from both limb and extraocular muscles (EOMs) in their histology and biochemistry. Weakness of the orbicularis oculi muscles is a
Zorzato, Francesco +11 more
core +1 more source
PLoS ONE, 2018 The α7 nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel that plays an important role in cellular calcium signaling contributing to synaptic development and plasticity, and is a key drug target for the treatment of neurodegenerative ...
Justin R King, Nadine Kabbani
doaj +1 more source
Frontiers in Cellular Neuroscience, 2021 Ginkgolide B (GB), a terpene lactone and active ingredient of Ginkgo biloba, shows protective effects in neuronal cells subjected to hypoxia. We investigated whether GB might protect neurons from hypoxic injury through regulation of neuronal Ca2 ...
Li Wang +7 more
doaj +1 more source