Cell Reports, 2018 Summary: Formation of synapses between motor neurons and muscles is initiated by clustering of acetylcholine receptors (AChRs) in the center of muscle fibers prior to nerve arrival. This AChR patterning is considered to be critically dependent on calcium
Mehmet Mahsum Kaplan +8 more
doaj +1 more source
Molecular, Subcellular, and Arrhythmogenic Mechanisms in Genetic RyR2 Disease
Biomolecules, 2022 The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple functional domains with specific roles, and four of these RyR2 protomers are ...
Ewan Douglas Fowler +1 more
doaj +1 more source
Calcium Ion as a Second Messenger With Special Reference to Excitation-Contraction Coupling
Journal of Pharmacological Sciences, 2006 .: Calcium ion (Ca2+) plays an important role in stimulus-response reactions of cells as a second messenger. This is done by keeping cytoplasmic Ca2+ concentration low at rest and by mobilizing Ca2+ in response to stimulus, which in turn activates the ...
Makoto Endo
doaj +1 more source
European Journal of Medical Research, 2021 Background Patients with severe COVID-19 have disorders of the respiratory, cardiovascular, coagulation, skeletal muscle, and central nervous systems. These systemic failures may be associated with cytokine release syndrome, characterized by hyperpyrexia,
Nobutaka Chiba +5 more
doaj +1 more source
Interval training normalizes cCardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy [PDF]
, 2009 In the present study we explored the mechanisms behind excitation-contraction (EC)-coupling defects in cardiomyocytes from mice with type-2 diabetes (db/db), and determined whether 13-weeks of aerobic interval training could restore cardiomyocyte Ca2 ...
Aasum, E. +10 more
core +2 more sources
Adenine dinucleotide second messengers and T-lymphocyte calcium signaling
Frontiers in Immunology, 2013 Calcium signaling is a universal signal transduction mechanism in animal and plant cells. In mammalian T-lymphocytes calcium signaling is essential for activation and re-activation and thus important for a functional immune response.
Insa MA Ernst +2 more
doaj +1 more source
When, where and how? Focus on neuronal calcium dysfunctions in Alzheimer's Disease. [PDF]
, 2016 Alzheimer\u2019s disease (AD), since its characterization as a precise form of dementia with its own pathological hallmarks, has captured scientists\u2019 attention because of its complexity.
AGOSTINI, MARIO, FASOLATO, CRISTINA
core +1 more source
VDAC2-mediated regulation of calcium homeostasis in cardiomyocytes (a review)
Кубанский научный медицинский вестник, 2020 Background. Cardiovascular diseases, especially in association with arrhythmias, remain a prevailing cause of death worldwide. Arrhythmia related to imbalanced Ca2+ homeostasis is triggered by aberrant spontaneous diastolic Ca2+ leak from sarcoplasmic ...
N. V. Schcetinina, A. A. Bolotskaia
doaj +1 more source
Junctional sarcoplasmic reticulum motility in adult mouse ventricular myocytes. [PDF]
, 2020 Excitation-contraction (EC) coupling is the coordinated process by which an action potential triggers cardiac myocyte contraction. EC coupling is initiated in dyads where the junctional sarcoplasmic reticulum (jSR) is in tight proximity to the sarcolemma
de la Mata, Ana +5 more
core +2 more sources
Human cardiomyocyte calcium handling and transverse tubules in mid-stage of post-myocardial-infarction heart failure [PDF]
, 2018 Aims: Cellular processes in the heart rely mainly on studies from experimental animal models or explanted hearts from patients with terminal end-stage heart failure (HF).
Condorelli, Gianluigi +12 more
core +2 more sources