Results 71 to 80 of about 4,095,708 (243)

Voltage sensing mechanism in skeletal muscle excitation-contraction coupling: coming of age or midlife crisis?

Skeletal Muscle, 2018
The process by which muscle fiber electrical depolarization is linked to activation of muscle contraction is known as excitation-contraction coupling (ECC).
Erick O. Hernández-Ochoa, Martin F. Schneider   +1 more
doaj   +1 more source

Contribution of NAADP to Glutamate-Evoked Changes in Ca2+ Homeostasis in Mouse Hippocampal Neurons

Frontiers in Cell and Developmental Biology, 2020
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that evokes calcium release from intracellular organelles by the engagement of calcium release channels, including members of the Transient Receptor Potential (TRP) family, such ...
Julia Hermann, Melanie Bender, Dagmar Schumacher, Dagmar Schumacher, Marcel S. Woo, Artem Shaposhnykov, Sina C. Rosenkranz, Vladimir Kuryshev, Vladimir Kuryshev, Chris Meier, Andreas H. Guse, Manuel A. Friese, Marc Freichel, Marc Freichel, Volodymyr Tsvilovskyy, Volodymyr Tsvilovskyy   +15 more
doaj   +1 more source

Dependency of calcium alternans on ryanodine receptor refractoriness. [PDF]

PLoS ONE, 2013
BACKGROUND: Rapid pacing rates induce alternations in the cytosolic calcium concentration caused by fluctuations in calcium released from the sarcoplasmic reticulum (SR).
Enric Alvarez-Lacalle, Inma R Cantalapiedra, Angelina Peñaranda, Juan Cinca, Leif Hove-Madsen, Blas Echebarria   +5 more
doaj   +1 more source

Structural insights into transmembrane helix S0 facilitated RyR1 channel gating by Ca2+/ATP

Nature Communications
The type-1 ryanodine receptor (RyR1) is an intracellular calcium release channel for skeletal muscle excitation-contraction coupling. Previous structural studies showed that the RyR1 activity is modulated by the exogenous regulators including caffeine ...
Risheng Wei, Qiang Chen, Lei Zhang, Congcong Liu, Chuang Liu, Chang-Cheng Yin, Hongli Hu   +6 more
doaj   +1 more source

Ryanodine receptor/calcium release channel conformations as reflected in the different effects of propranolol on its ryanodine binding and channel activity [PDF]

Biochemical Journal, 1996
1. Propranolol, a β-blocker, inhibited or stimulated ryanodine binding to both the membrane-bound and purified ryanodine receptor (RyR) depending on the assay conditions. At high NaCl concentrations, propranolol increased the number of ryanodine-binding sites (Bmax) with no effect on the binding affinity.
S, Zchut, W, Feng, V, Shoshan-Barmatz
openaire   +2 more sources

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Sphingosylphosphocholine modulates the ryanodine receptor/calcium-release channel of cardiac sarcoplasmic reticulum membranes [PDF]

Biochemical Journal, 1997
Sphingosylphosphocholine (SPC) modulates Ca2+ release from isolated cardiac sarcoplasmic reticulum membranes; 50 ƁM SPC induces the release of 70Ő80% of the accumulated calcium. SPC releases calcium from cardiac sarcoplasmic reticulum through the ryanodine receptor, since the release is inhibited by the ryanodine receptor channel antagonists ryanodine,
R Betto, A Teresi, F Turcato, G Salviati, RA Sabbadini, K Krown, CC Glembotski, LA Kindman, C Dettbarn, Y Pereon, K Yasui, PT Palade   +11 more
openaire   +3 more sources

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

IP₃R-Mediated Calcium Release Promotes Ferroptotic Death in SH-SY5Y Neuroblastoma Cells

Antioxidants
Ferroptosis is an iron-dependent cell death pathway that involves the depletion of intracellular glutathione (GSH) levels and iron-mediated lipid peroxidation. Ferroptosis is experimentally caused by the inhibition of the cystine/glutamate antiporter xCT,
Joaquín Campos, Silvia Gleitze, Cecilia Hidalgo, Marco T. Núñez   +3 more
doaj   +1 more source

RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation

Acta Neuropathologica Communications, 2021
The type 1 ryanodine receptor (RyR1) is an intracellular calcium (Ca2+) release channel on the sarcoplasmic/endoplasmic reticulum that is required for skeletal muscle contraction.
Qi Yuan, Haikel Dridi, Oliver B. Clarke, Steven Reiken, Zephan Melville, Anetta Wronska, Alexander Kushnir, Ran Zalk, Leah Sittenfeld, Andrew R. Marks   +9 more
doaj   +1 more source