Results 61 to 70 of about 28,867 (291)

Physiology and Pharmacology of Ryanodine Receptor Calcium Release Channels

, 2017
Ryanodine receptor (RyR) ion channels are essential for skeletal and cardiac muscle function. Their knockout leads to perinatal death from respiratory and cardiac failure. Acquired changes or mutations in the protein cause debilitating skeletal myopathy and cardiac arrhythmia which can be deadly. Knowledge of the pharmacology of RyR channels is central
Dulhunty, Angela, Board, Philip, Beard, Nicole, Casarotto, Marco   +3 more
openaire   +3 more sources

The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis [PDF]

, 2019
Aims: Single nucleotide polymorphisms on chromosome 4q25 have been associated with risk of atrial fibrillation (AF) but the exiguous knowledge of the mechanistic links between these risk variants and underlying electrophysiological alterations hampers ...
Benítez Iglesias, Raúl, Gandía, Jorge, Herraiz Martínez, Adela, Jiménez Sábado, Verónica, Llach Martínez, Anna, Lozano Velasco, Estefanía, Serra Pascual, Selma A., Tarifa Lora, Carmen, Vallmitjana Lees, Alexander, Vázquez Ruiz de Castroviejo, Eduardo   +9 more
core   +2 more sources

Electrophysiological Mechanisms and Therapeutic Potential of Calcium Channels in Atrial Fibrillation

Reviews in Cardiovascular Medicine
Atrial fibrillation (AF) is a prevalent and complex arrhythmia for which the pathogenesis involves various electrophysiological factors, notably the regulation of calcium channels.
Zuyuan Huang, Cheng Luo, Zimin Wu, Baoshi Zheng   +3 more
doaj   +1 more source

FKBP12 Depletion Leads to Loss of Sarcoplasmic Reticulum Ca2+ Stores in Rat Vas Deferens

Journal of Pharmacological Sciences, 2009
The immunophilin 12-kDa FK506 binding protein (FKBP12) stabilizes intracellular Ca2+ release channel (CRC) activity in different tissues. In this work, the presence of FKBP12 in rat vas deferens (RVD) and its possible contribution to RVD function was ...
Christianne B.V. Scaramello, Humberto Muzi-Filho, Gisele Zapata-Sudo, Roberto T. Sudo, Valéria do M.N. Cunha   +4 more
doaj   +1 more source

Altered excitation-contraction coupling in human chronic atrial fibrillation [PDF]

, 2012
This review focuses on the (mal)adaptive processes in atrial excitation-contraction coupling occurring in patients with chronic atrial fibrillation. Cellular remodeling includes shortening of the atrial action potential duration and effective refractory ...
Grandi, E., Pandit, S.V., Workman, A.J.
core   +1 more source

Sphingosylphosphocholine modulates the ryanodine receptor/calcium-release channel of cardiac sarcoplasmic reticulum membranes [PDF]

Biochemical Journal, 1997
Sphingosylphosphocholine (SPC) modulates Ca2+ release from isolated cardiac sarcoplasmic reticulum membranes; 50 ƁM SPC induces the release of 70Ő80% of the accumulated calcium. SPC releases calcium from cardiac sarcoplasmic reticulum through the ryanodine receptor, since the release is inhibited by the ryanodine receptor channel antagonists ryanodine,
R Betto, A Teresi, F Turcato, G Salviati, RA Sabbadini, K Krown, CC Glembotski, LA Kindman, C Dettbarn, Y Pereon, K Yasui, PT Palade   +11 more
openaire   +3 more sources

The N-Terminal Region of the Ryanodine Receptor Affects Channel Activation

Frontiers in Physiology, 2017
Mutations in the cardiac ryanodine receptor (RyR2), the ion channel responsible for release of calcium ions from intracellular stores into cytoplasm, are the cause of several inherited cardiac arrhythmias.
Andrea Faltinova, Andrea Faltinova, Nataša Tomaskova, Marián Antalik, Jozef Sevcik, Alexandra Zahradnikova, Alexandra Zahradnikova   +6 more
doaj   +1 more source

The Ryanodine Receptor/Calcium Release Channel and its Interaction Partners

Microscopy and Microanalysis, 1998
Abstract Ryanodine receptors (RyRs) function as the major intracellular calcium release channels in striated muscle, where they also play a central role in excitation-contraction (e-c) coupling, the signal transduction process by which neuron-induced depolarization of the muscle plasma membrane leads to release of Ca from the ...
Terry Wagenknecht, Montserrat Samso
openaire   +1 more source

Additive‐Manufactured, Multifunctional Bioreactor Technology for Dynamic Culture of 3D Bioprinted Tissue Models

Advanced Materials Technologies, EarlyView.
We introduce an additively manufactured bioreactor with a perfusion flow system and integrated temperature and pH sensors for skeletal muscle tissue biofabrication. The bioreactor's performance was evaluated by assessing the viability, spreading of the myoblast cells in a printed scaffold, and contraction of the isolated murine musculi interossei ...
Lys Sprenger, Johann Schorzmann, Hsuan‐Heng Lu, Muhammad Osama, Julian Bauer, Michael Haug, Oliver Friedrich, Aldo R. Boccaccini, Frank Döpper, Sahar Salehi   +9 more
wiley   +1 more source

Construction of calcium release sites in cardiac myocytes

Frontiers in Physiology, 2012
Local character of calcium release in cardiac myocytes, as defined by confocal recordings of calcium sparks, implies independent activation of individual calcium release sites based on ryanodine receptor (RyR) channel recruitment.
Alexandra eZahradnikova, Alexandra eZahradnikova, Ivan eZahradnik   +2 more
doaj   +1 more source