Results 41 to 50 of about 4,095,708 (243)

Calmodulin Binding and Inhibition of Cardiac Muscle Calcium Release Channel (Ryanodine Receptor) [PDF]

Journal of Biological Chemistry, 2001
Metabolically (35)S-labeled calmodulin (CaM) was used to determine the CaM binding properties of the cardiac ryanodine receptor (RyR2) and to identify potential channel domains for CaM binding. In addition, regulation of RyR2 by CaM was assessed in [(3)H]ryanodine binding and single-channel measurements.
D M, Balshaw, L, Xu, N, Yamaguchi, D A, Pasek, G, Meissner   +4 more
openaire   +2 more sources

FKBP12.6 activates RyR1 : investigating the amino acid residues critical for channel modulation [PDF]

, 2014
Funding: British Heart FoundationWe have previously shown that FKBP12 associates with RyR2 in cardiac muscle and that it modulates RyR2 function differently to FKBP12.6.
Richard B. Sessions, Elisa Venturi, O'Brien, Fiona, Rebecca Sitsapesan, Fiona O’Brien, Bellamy, Stuart, Pitt, Samantha J, Stuart Bellamy, Sitsapesan, Rebecca, Sessions, Richard B., Elena Galfré, Pitt, Samantha J., Galfre, Elena, O’Brien, Fiona, Samantha J. Pitt, Sessions, Richard B, Venturi, Elisa   +16 more
core   +1 more source

Role of the JP45-Calsequestrin Complex on Calcium Entry in Slow Twitch Skeletal Muscles [PDF]

, 2016
We exploited a variety of mouse models to assess the roles of JP45-CASQ1 (CASQ, calsequestrin) and JP45-CASQ2 on calcium entry in slow twitch muscles.
Treves S, Treves, Susan, TREVES, Susan Nella, Protasi F, De Negri M4, Bongianino, Rossana, Bergamelli L, De Negri M, Bongianino R4, Mosca B, Priori, Silvia G., Priori SG, Zorzato, Francesco, Eckhardt J, Eckhardt, Jan, Mosca, Barbara, Bergamelli, Leda, Protasi F6, PRIORI, SILVIA GIULIANA, Zorzato F, De Negri, Marco, Eckhardt J2, Protasi, Feliciano, Bongianino R, Priori SG5   +24 more
core   +1 more source

SEQUENCE VARIANTS IN THE RYR1 GENE AND GENETIC DISEASES: MALIGNANT HYPERTHERMIA AND CONGENITAL MYOPATHIES [PDF]

, 2009
This PhD thesis has been focused on the identification and functional characterization of sequence variants in the RYR1 gene, associated with Malignant hyperthermia (MH) and some congenital myopathies (CMs).
Perrotta, Giuseppa
core   +1 more source

Electrophysiological Mechanisms and Therapeutic Potential of Calcium Channels in Atrial Fibrillation

Reviews in Cardiovascular Medicine
Atrial fibrillation (AF) is a prevalent and complex arrhythmia for which the pathogenesis involves various electrophysiological factors, notably the regulation of calcium channels.
Zuyuan Huang, Cheng Luo, Zimin Wu, Baoshi Zheng   +3 more
doaj   +1 more source

VDAC2-mediated regulation of calcium homeostasis in cardiomyocytes (a review)

Кубанский научный медицинский вестник, 2020
Background. Cardiovascular diseases, especially in association with arrhythmias, remain a prevailing cause of death worldwide. Arrhythmia related to imbalanced Ca2+ homeostasis is triggered by aberrant spontaneous diastolic Ca2+ leak from sarcoplasmic ...
N. V. Schcetinina, A. A. Bolotskaia
doaj   +1 more source

Reversible Block of the Calcium Release Channel/Ryanodine Receptor by Protamine, a Heparin Antidote [PDF]

Molecular Biology of the Cell, 2000
Channel activity of the calcium release channel from skeletal muscle, ryanodine receptor type 1, was measured in the presence and absence of protamine sulfate on the cytoplasmic side of the channel. Single-channel activity was measured after incorporating channels into planar lipid bilayers.
P, Koulen, B E, Ehrlich
openaire   +2 more sources

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

The molecular dysregulation of excitation contraction coupling in patients with congenital muscle disorders [PDF]

, 2015
Excitation contraction coupling (ECC) is the process whereby an action potential spreading throughout the muscle membrane activates muscle contraction, by releasing Ca2+ from the Sarcoplasmic Reticulum (SR).
Rokach, Ori
core   +1 more source

From Temperature Fluctuations to Precise Control: Biochemical Techniques Integrated Digital‐Intelligent Technology for Vegetable Preservation

Future Postharvest and Food, EarlyView.
The physiological effects and molecular responses of postharvest vegetables to temperature fluctuations, and multi‐technology integration strategies for maintaining postharvest vegetable quality. ABSTRACT Vegetables are indispensable agricultural products in the human diet. With the continuous growth of vegetable production and consumption, postharvest
Shuaishuai Dai, Kuo Chen, Xing Xing, Liqun Ma, Hongliang Zhu   +4 more
wiley   +1 more source