Ryanodine receptor 2 promotes colorectal cancer metastasis by the ROS/BACH1 axis [PDF]
Molecular Oncology, 2023 There is no targeted therapy for KRAS proto‐oncogene, GTPase (KRAS)‐mutant metastatic colorectal cancer (mCRC) because the underlying mechanism remains obscure.
Tianwei Chen +6 more
doaj +2 more sources
Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory [PDF]
Communications Biology, 2022 A mouse model containing a GFP-tagged ryanodine receptor 2 (RyR2) has shed light on the precise subcellular localization of hippocampal RyR2 and mechanisms underlying neuronal excitability, learning, and memory.
Florian Hiess +15 more
doaj +2 more sources
Novel mutation in N-terminal fragment of ryanodine receptor 2 causing catecholaminergic polymorphic ventricular tachycardia [PDF]
Indian Pacing and Electrophysiology Journal, 2023 CPVT is a rare inherited arrhythmogenic disorder characterized by bidirectional, polymorphic ventricular arrhythmias triggered by catecholamines released during exercise, stress, or sudden emotion in individuals with a normal resting electrocardiogram ...
Sania Jiwani, Amit Noheria
doaj +2 more sources
Phosphorylation-Dependent Interactome of Ryanodine Receptor Type 2 in the Heart [PDF]
Proteomes, 2021 Hyperphosphorylation of the calcium release channel/ryanodine receptor type 2 (RyR2) at serine 2814 (S2814) is associated with multiple cardiac diseases including atrial fibrillation and heart failure.
David Y. Chiang +8 more
doaj +5 more sources
Foxp3-mediated blockage of ryanodine receptor 2 underlies contact-based suppression by regulatory T cells [PDF]
The Journal of Clinical Investigation, 2023 The suppression mechanism of Tregs remains an intensely investigated topic. As our focus has shifted toward a model centered on indirect inhibition of DCs, a universally applicable effector mechanism controlled by the transcription factor forkhead box P3
Xiaobo Wang +25 more
doaj +2 more sources
Rhynchophylline Regulates Calcium Homeostasis by Antagonizing Ryanodine Receptor 2 Phosphorylation to Improve Diabetic Cardiomyopathy [PDF]
Frontiers in Pharmacology, 2022 Diabetic cardiomyopathy (DCM) is a serious complication of diabetes that can lead to heart failure and death, for which there is no effective treatment.
Jiao Liu +9 more
doaj +2 more sources
A novel mutation in ryanodine receptor 2 (RYR2) genes at c.12670G>T associated with focal epilepsy in a 3-year-old child [PDF]
Frontiers in Pediatrics, 2022 BackgroundRyanodine receptor 2 (RYR2) encodes a component of a calcium channel. RYR2 variants were well-reported to be associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), but rarely reported in epilepsy cases. Here, we present a
Junji Hu +7 more
doaj +2 more sources
The role of subunit cooperativity on ryanodine receptor 2 calcium signaling. [PDF]
Biophys J, 2023 The ryanodine receptor type 2 (RyR2) is composed of four subunits that control calcium (Ca) release in cardiac cells. RyR2 serves primarily as a Ca sensor and can respond to rapid sub-millisecond pulses of Ca while remaining shut at resting concentrations.
Greene D, Luchko T, Shiferaw Y.
europepmc +3 more sources
Genetic Inhibition of Mitochondrial Permeability Transition Pore Exacerbates Ryanodine Receptor 2 Dysfunction in Arrhythmic Disease [PDF]
Cells, 2023 The brief opening mode of the mitochondrial permeability transition pore (mPTP) serves as a calcium (Ca2+) release valve to prevent mitochondrial Ca2+ (mCa2+) overload.
Arpita Deb +9 more
doaj +2 more sources
Multiple modes of ryanodine receptor 2 inhibition by flecainide. [PDF]
Mol Pharmacol, 2014 Catecholaminergic polymorphic ventricular tachycardia (CPVT) causes sudden cardiac death due to mutations in cardiac ryanodine receptors (RyR2), calsequestrin, or calmodulin. Flecainide, a class I antiarrhythmic drug, inhibits Na(+) and RyR2 channels and prevents CPVT. The purpose of this study is to identify inhibitory mechanisms of flecainide on RyR2.
Mehra D +4 more
europepmc +4 more sources