Results 41 to 50 of about 49,122 (245)

Pharmacogenomics of Pediatric Cardiac Arrest: Cisplatin Treatment Worsened by a Ryanodine Receptor 2 Gene Mutation

Cardiogenetics, 2022
In thelast few decades, the roles of cardio-oncology and cardiovascular geneticsgained more and more attention in research and daily clinical practice, shaping a new clinical approach and management of patients affected by cancer and cardiovascular ...
Angela Maggio, Sandra Mastroianno, Giuseppe Di Stolfo, Stefano Castellana, Pietro Palumbo, Maria Pia Leone, Anita Spirito, Domenico Rosario Potenza, Saverio Ladogana, Marco Castori, Massimo Carella, Massimo Villella, Mauro Pellegrino Salvatori   +12 more
doaj   +1 more source

Cardiac Specific Gene Expression Changes in Long Term Culture of Murine Mesenchymal Stem Cells [PDF]

, 2011
Murine MSCs are a readily available source of adult stem cells enabling extensive in vitro study of this cell population. MSCs have been described as multipotent, and have been proven capable of differentiation into several connective tissue types ...
Argyle, D.J., Argyle, S.A., Bennett, D., Corcoran, B.M., Hodgkiss-Geere, H.M., Milne, E., Whitelaw, B.   +6 more
core   +2 more sources

Interval training normalizes cCardiomyocyte function, diastolic Ca²⁺ control, and SR Ca²⁺ release synchronicity in a mouse model of diabetic cardiomyopathy [PDF]

, 2009
In the present study we explored the mechanisms behind excitation-contraction (EC)-coupling defects in cardiomyocytes from mice with type-2 diabetes (db/db), and determined whether 13-weeks of aerobic interval training could restore cardiomyocyte Ca2 ...
Aasum, E., Catalucci, D., Ceci, M., Condorelli, G., Høydal, M.A., Kemi, O.J., Larsen, T., Rolim, N., Smith, G.L., Stølen, T.O., Wisløff, U.   +10 more
core   +2 more sources

The neuroprotective mechanism of cinnamaldehyde against amyloid-β in neuronal SHSY5Y cell line: The role of N-methyl-D-aspartate, ryanodine, and adenosine receptors and glycogen synthase kinase-3β [PDF]

Avicenna Journal of Phytomedicine, 2019
Objective: Cinnamaldehyde may be responsible for some health benefits of cinnamon such as its neuroprotective effects. We aimed to investigate the cinnamaldehyde neuroprotective effects against amyloid beta (Aβ) in neuronal SHSY5Y cells and evaluate the ...
Masoumeh Emamghoreishi, Majid Farrokhi, Atena Amiri, Mojtaba Keshavarz   +3 more
doaj   +1 more source

Junctional sarcoplasmic reticulum motility in adult mouse ventricular myocytes. [PDF]

, 2020
Excitation-contraction (EC) coupling is the coordinated process by which an action potential triggers cardiac myocyte contraction. EC coupling is initiated in dyads where the junctional sarcoplasmic reticulum (jSR) is in tight proximity to the sarcolemma
de la Mata, Ana, Drum, Benjamin M, Grainger, Nathan, Grainger, Nathan, Santana, L Fernando, Yuan, Can   +5 more
core   +2 more sources

Glucose-Dependent Insulin Secretion in Pancreatic β-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors. [PDF]

PLoS ONE, 2015
Glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells requires an increase in intracellular free Ca2+ concentration ([Ca2+]). Glucose uptake into β-cells promotes Ca2+ influx and reactive oxygen species (ROS) generation. In other cell types,
Paola Llanos, Ariel Contreras-Ferrat, Genaro Barrientos, Marco Valencia, David Mears, Cecilia Hidalgo   +5 more
doaj   +1 more source

Early Findings in Neonatal Cases of RYR1–Related Congenital Myopathies

Frontiers in Neurology, 2021
Ryanodine receptor type 1-related congenital myopathies are the most represented subgroup among congenital myopathies (CMs), typically presenting a central core or multiminicore muscle histopathology and high clinical heterogeneity. We evaluated a cohort
Eleonora Mauri, Daniela Piga, Alessandra Govoni, Roberta Brusa, Serena Pagliarani, Michela Ripolone, Robertino Dilena, Claudia Cinnante, Monica Sciacco, Denise Cassandrini, Vincenzo Nigro, Nereo Bresolin, Nereo Bresolin, Stefania Corti, Stefania Corti, Giacomo P. Comi, Giacomo P. Comi, Francesca Magri   +17 more
doaj   +1 more source

Ca²⁺‐calmodulin can activate and inactivate cardiac ryanodine receptors [PDF]

British Journal of Pharmacology, 2009
Background and purpose: Ca2+‐calmodulin (Ca2+CaM) is widely accepted as an inhibitor of cardiac ryanodine receptors (RyR2); however, the effects of physiologically relevant CaM concentrations have not been fully investigated.Experimental approach: We investigated the effects of low concentrations of Ca2+CaM (50–100 nmol·L−1) on the gating of native ...
Sigalas, C, Bent, S, Kitmitto, A, O'Neill, S, Sitsapesan, R   +4 more
openaire   +3 more sources

The possibility of positive selection for both F18(+) Escherichia coli and stress resistant pigs opens new perspectives for pig breeding [PDF]

, 2007
International ...
Coddens, Annelies, Cox, Eric, Duchateau, Luc, Goddeeris, Bruno, GOYVAERTS, E, MIRY, C, MULINGE, M, Verdonck, Frank   +7 more
core   +3 more sources

Differential Downregulation of β1‐Adrenergic Receptor Signaling in the Heart

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Chronic sympathetic stimulation drives desensitization and downregulation of β1 adrenergic receptor (β1AR) in heart failure. We aim to explore the differential downregulation subcellular pools of β1AR signaling in the heart.
Bing Xu, Sherif Bahriz, Victoria R. Salemme, Ying Wang, Chaoqun Zhu, Meimi Zhao, Yang K. Xiang   +6 more
doaj   +1 more source