Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology. [PDF]
, 2009 The cause(s) of sporadic Alzheimer's disease (sAD) are complex and currently poorly understood. They likely result from a combination of genetic, environmental, proteomic and lipidomic factors that crucially occur only in the aged brain.
Green, Kim N
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Calcium handling in human induced pluripotent stem cell derived cardiomyocytes. [PDF]
PLoS ONE, 2011 BACKGROUND: The ability to establish human induced pluripotent stem cells (hiPSCs) by reprogramming of adult fibroblasts and to coax their differentiation into cardiomyocytes opens unique opportunities for cardiovascular regenerative and personalized ...
Ilanit Itzhaki +7 more
doaj +1 more source
Antioxidants, 2023 Ferroptosis, a newly described form of regulated cell death, is characterized by the iron-dependent accumulation of lipid peroxides, glutathione depletion, mitochondrial alterations, and enhanced lipoxygenase activity.
Silvia Gleitze +8 more
doaj +1 more source
Targeting RyR Activity Boosts Antisense Exon 44 and 45 Skipping in Human DMD Skeletal or Cardiac Muscle Culture Models. [PDF]
, 2019 Systemic delivery of antisense oligonucleotides (AO) for DMD exon skipping has proven effective for reframing DMD mRNA, rescuing dystrophin expression, and slowing disease progression in animal models.
Barthélémy, Florian +6 more
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Presenilin 2 Interacts with Sorcin, a Modulator of the Ryanodine Receptor [PDF]
Journal of Biological Chemistry, 2000 Perturbed Ca(2+) homeostasis is a common molecular consequence of familial Alzheimer's disease-linked presenilin mutations. We report here the molecular interaction of the large hydrophilic loop region of presenilin 2 (PS2) with sorcin, a penta-EF-hand Ca(2+)-binding protein that serves as a modulator of the ryanodine receptor intracellular Ca(2 ...
E, Pack-Chung +7 more
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RyR2 QQ2958 Genotype and Risk of Malignant Ventricular Arrhythmias
Cardiology Research and Practice, 2016 Ventricular arrhythmias are one of the most common causes of death in developed countries. The use of implantable cardiac defibrillators is the most effective treatment to prevent sudden cardiac death.
Francesca Galati +2 more
doaj +1 more source
A 16-step synthesis of the isoryanodane diterpene (+)-perseanol [PDF]
, 2019 (+)-Perseanol is an isoryanodane diterpene that is isolated from the tropical shrub Persea indica and has potent antifeedant and insecticidal properties.
Han, Arthur +2 more
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A Regulatory Component of the Human Ryanodine Receptor 2 N-Terminus [PDF]
Biophysical Journal, 2014 Human cardiac ryanodine receptor (hRyR2) is a channel mediating Ca2+ release from the sarcoplasmic reticulum during excitation-contraction coupling. The N-terminal (1-655) and central (2100-2500) regions of hRyR2 are thought to be involved in regulating channel gating.
Borko, Lubomir +8 more
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Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders
Nature CommunicationsHeart failure, the leading cause of mortality and morbidity in the developed world, is characterized by cardiac ryanodine receptor 2 channels that are hyperphosphorylated, oxidized, and depleted of the stabilizing subunit calstabin-2.
Marco C. Miotto +8 more
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Enhanced calcium release in the acute neuronopathic form of Gaucher disease
Neurobiology of Disease, 2005 Gaucher disease is an inherited metabolic disorder caused by defective activity of the lysosomal enzyme, glucocerebrosidase, resulting in accumulation of the lipids, glucosylceramide (GlcCer), and glucosylsphingosine (GlcSph).
Dori Pelled +5 more
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