Results 71 to 80 of about 49,122 (245)

Ryanodine receptor-2: a necessity for gating store-operated Ca²⁺channels [PDF]

Cardiovascular Research, 2016
This editorial refers to ‘Conformation of ryanodine receptor-2 gates store-operated calcium entry in rat pulmonary arterial myocytes’ by A.H.Y. Lin et al ., pp. 94–104. Store-operated Ca2+ entry (SOCE) is an important regulator of vascular tone as it is linked to a variety of functions including contraction, proliferation, and migration.1,2 It is ...
Shanshan, Song, Ramon J, Ayon, Jason X-J, Yuan   +2 more
openaire   +2 more sources

Illuminating the Intracellular World: Breakthroughs in Nanoscale Optoelectronics

Advanced Electronic Materials, EarlyView.
This perspective explores optoelectronic biointerfaces spanning macroscale flexible devices to nanoscale intracellular systems, emphasizing their integration across dimensions. It examines capacitive, Faradaic, and photothermal mechanisms that enable light‐driven control of cellular activity and highlights key material and design challenges in ...
Tania Assaf, Menahem Y. Rotenberg
wiley   +1 more source

Sacubitril/valsartan preserves regional cardiac function following myocardial infarction in rats

ESC Heart Failure, Volume 12, Issue 2, Page 1304-1315, April 2025.
Parts of the figure were drawn by using pictures from Servier Medical Art. Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/). Abstract Aims Sacubitril/valsartan (Sac/Val) is used for treatment of heart failure. The effect of Sac/Val on regional dysfunction
Einar Sjaastad Nordén, Bård Andre Bendiksen, Kaja Knudsen Bergo, Emil Knut Stenersen Espe, Gary McGinley, Almira Hasic, Ida Marie Hauge‐Iversen, Hege Katrin Ugland, Xin Shen, Michael Frisk, Nishani S. Mabotuwana, William E. Louch, Rizwan I. Hussain, Lili Zhang, Ivar Sjaastad, Alessandro Cataliotti, Geir Christensen   +16 more
wiley   +1 more source

Arrhythmogenic Right Ventricular Dysplasia in Neuromuscular Disorders

Clinical Medicine Insights: Cardiology, 2016
Objectives Arrhythmogenic right ventricular dysplasia (ARVD) is a rare, genetic disorder predominantly affecting the right ventricle. There is increasing evidence that in some cases, ARVD is due to mutations in genes, which have also been implicated in ...
Josef Finsterer, Claudia Stöllberger
doaj   +1 more source

True Molecular Scale Visualization of Variable Clustering Properties of Ryanodine Receptors

Cell Reports, 2018
Summary: Signaling nanodomains rely on spatial organization of proteins to allow controlled intracellular signaling. Examples include calcium release sites of cardiomyocytes where ryanodine receptors (RyRs) are clustered with their molecular partners ...
Isuru Jayasinghe, Alexander H. Clowsley, Ruisheng Lin, Tobias Lutz, Carl Harrison, Ellen Green, David Baddeley, Lorenzo Di Michele, Christian Soeller   +8 more
doaj   +1 more source

The disease mutation A77V in Ryanodine receptor RyR2 induces changes in energy conduction pathways in the protein [PDF]

, 2011
Energetically responsive residues of the 217 amino acid N-terminal domain of the cardiac Ryanodine receptor RyR2 are identified by a simple elastic net model. These residues lie along a hydrogen bonded path through the protein.
Burak Erman, Nazan Walpoth
core   +1 more source

Structural and functional conservation of key domains in InsP3 and ryanodine receptors. [PDF]

, 2012
Inositol-1,4,5-trisphosphate receptors (InsP(3)Rs) and ryanodine receptors (RyRs) are tetrameric intracellular Ca(2+) channels. In each of these receptor families, the pore, which is formed by carboxy-terminal transmembrane domains, is regulated by ...
Ames, James B, Dale, Philippa, Ikura, Mitsuhiko, Ishiyama, Noboru, Khan, Samir A, Li, Congmin, Rossi, Ana M, Seo, Min-Duk, Stathopulos, Peter B, Taylor, Colin W, Velamakanni, Saroj   +10 more
core   +1 more source

Altered Stoichiometry of FKBP12.6 Versus Ryanodine Receptor as a Cause of Abnormal Ca ²⁺ Leak Through Ryanodine Receptor in Heart Failure [PDF]

Circulation, 2000
Background —In the pathogenesis of cardiac dysfunction in heart failure, a decrease in the activity of the sarcoplasmic reticulum (SR) Ca 2+ -ATPase is believed to be a major determinant. Here, we report a novel mechanism of cardiac dysfunction revealed by assessing the functional interaction of FK506 ...
M, Yano, K, Ono, T, Ohkusa, M, Suetsugu, M, Kohno, T, Hisaoka, S, Kobayashi, Y, Hisamatsu, T, Yamamoto, M, Kohno, N, Noguchi, S, Takasawa, H, Okamoto, M, Matsuzaki   +13 more
openaire   +2 more sources

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

Mitochondrial ryanodine receptors and other mitochondrial Ca²⁺ permeable channels [PDF]

FEBS Letters, 2010
Ca2+ channels that underlie mitochondrial Ca2+ transport first reported decades ago have now just recently been precisely characterized electrophysiologically. Numerous data indicate that mitochondrial Ca2+ uptake via these channels regulates multiple intracellular processes by shaping cytosolic and mitochondrial Ca2+ transients, as well as altering ...
Ryu, Shin-Young, Beutner, Gisela, Dirksen, Robert T., Kinnally, Kathleen W., Sheu, Shey-Shing   +4 more
openaire   +2 more sources