Results 11 to 20 of about 49,122 (245)

Macrophage-mediated IL-6 signaling drives ryanodine receptor–2 calcium leak in postoperative atrial fibrillation [PDF]

The Journal of Clinical Investigation
Postoperative atrial fibrillation (poAF) is AF occurring days after surgery, with a prevalence of 33% among patients undergoing open-heart surgery. The degree of postoperative inflammation correlates with poAF risk, but less is known about the cellular ...
Joshua A. Keefe, Yuriana Aguilar-Sanchez, J. Alberto Navarro-Garcia, Isabelle Ong, Luge Li, Amelie Paasche, Issam Abu-Taha, Marcel A. Tekook, Florian Bruns, Shuai Zhao, Markus Kamler, Ying H. Shen, Mihail G. Chelu, Na Li, Dobromir Dobrev, Xander H.T. Wehrens   +15 more
doaj   +2 more sources

A circular RNA derived from the ryanodine receptor 2 locus controls cardiac hypertrophy and calcium handling [PDF]

Cellular and Molecular Life Sciences
Heart failure (HF) is a leading cause of mortality worldwide, characterized by structural and functional alterations that result in reduced cardiac function. During the progression of HF, cardiomyocytes undergo profound remodeling – including development
Wen Pan, Hannah J. Hunkler, Shambhabi Chatterjee, Dongchao Lu, Isabelle Riedel, Anika Gietz, Ke Xiao, Maximilian Fuchs, Dimyana Neufeldt, Theresia Kraft, Cheng-Kai Huang, Sarah Cushman, Anne Bührke, Arne Schmidt, Elisa Mohr, Natalie Weber, Christian Bär, Thomas Thum   +17 more
doaj   +2 more sources

Insights into the gating mechanism of the ryanodine-modified human cardiac Ca2+-release channel (ryanodine receptor 2). [PDF]

Mol Pharmacol, 2014
Ryanodine receptors (RyRs) are intracellular membrane channels playing key roles in many Ca(2+) signaling pathways and, as such, are emerging novel therapeutic and insecticidal targets. RyRs are so named because they bind the plant alkaloid ryanodine with high affinity and although it is established that ryanodine produces profound changes in all ...
Mukherjee S, Thomas NL, Williams AJ.
europepmc   +6 more sources

S100A1 DNA-based Inotropic Therapy Protects Against Proarrhythmogenic Ryanodine Receptor 2 Dysfunction. [PDF]

Mol Ther, 2015
Restoring expression levels of the EF-hand calcium (Ca(2+)) sensor protein S100A1 has emerged as a key factor in reconstituting normal Ca(2+) handling in failing myocardium. Improved sarcoplasmic reticulum (SR) function with enhanced Ca(2+) resequestration appears critical for S100A1's cyclic adenosine monophosphate-independent inotropic effects but ...
Ritterhoff J, Völkers M, Seitz A, Spaich K, Gao E, Peppel K, Pleger ST, Zimmermann WH, Friedrich O, Fink RHA, Koch WJ, Katus HA, Most P.   +12 more
europepmc   +5 more sources

MYBPC3 (c.194 C > T) mutation-mediated RyR2 dysfunction contributes to pathogenic phenotypes of DCM revealed by HiPSC modeling [PDF]

Cellular and Molecular Life Sciences
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and the primary indication for heart transplantation. The intricate and poorly elucidated pathogenesis of genetic DCM, coupled with the paucity of effective therapeutic options, imposes a ...
Manting Xie, Bingbing Xie, Liang Huang, Ying Chen, Xingqiang Lai, Mingqi Yan, Jixing Gong, Nan Cao, Andy Peng Xiang, Qiuling Xiang   +9 more
doaj   +2 more sources

Role of type 2 ryanodine receptor stabilisation in autoimmune cell modulation

Advances in Rheumatology
Takashi Nawata, Takeshi Honda, Akihiko Sakamoto, Hitoshi Uchinoumi, Takeshi Suetomi, Yoshihide Nakamura, Shunya Tsuji, Hiroki Sakai, Shigeki Kobayashi, Takeshi Yamamoto, Masataka Asagiri, Motoaki Sano, Masafumi Yano   +12 more
doaj   +3 more sources

Ryanodine receptor‐2 upregulation and nicotine‐mediated plasticity [PDF]

The EMBO Journal, 2010
Nicotine, the major psychoactive component of cigarette smoke, modulates neuronal activity to produce Ca2+-dependent changes in gene transcription. However, the downstream targets that underlie the long-term effects of nicotine on neuronal function, and hence behaviour, remain to be elucidated.
E. Ziviani, LIPPI, Giordano, D. Bano, E. Munarriz, GUIDUCCI, Stefania, ZOLI, Michele, KW Young, P. Nicotera   +7 more
openaire   +2 more sources

Ryanodine Sensitizes the Ca2+ Release Channel (Ryanodine Receptor) to Ca2+ Activation [PDF]

Journal of Biological Chemistry, 2001
Ryanodine, a plant alkaloid, is one of the most widely used pharmacological probes for intracellular Ca(2+) signaling in a variety of muscle and non-muscle cells. Upon binding to the Ca(2+) release channel (ryanodine receptor), ryanodine causes two major changes in the channel: a reduction in single-channel conductance and a marked increase in open ...
H, Masumiya, P, Li, L, Zhang, S R, Chen
openaire   +2 more sources

Extra Virgin Olive Oil Phenols Vasodilate Rat Mesenteric Resistance Artery via Phospholipase C (PLC)-Calcium Microdomains-Potassium Channels (BK_Ca) Signals

Biomolecules, 2021
Recent evidence suggests that the reason Extra Virgin Olive Oil (EVOO) lowers blood pressure and reduces the risk of developing hypertension is partly due to minor components of EVOO, such as phenols. However, little is still known about the mechanism(s)
Rossana D’Agostino, Laura Barberio, Mariacarmela Gatto, Teresa Tropea, Maria De Luca, Maurizio Mandalà   +5 more
doaj   +1 more source

Bcl-2 binds to and inhibits ryanodine receptors [PDF]

Journal of Cell Science, 2014
The anti-apoptotic B-cell lymphoma-2 (Bcl-2) protein not only counteracts apoptosis at the mitochondria by scaffolding pro-apoptotic Bcl-2-family members, but also acts at the endoplasmic reticulum, thereby controlling intracellular Ca2+ dynamics. Bcl-2 inhibits Ca2+ release by targeting the inositol 1,4,5-trisphosphate receptor (IP3R).
Vervliet, T., Decrock, E., Molgó, J., Sorrentino, V., Missiaen, L., Leybaert, L., de Smedt, H., Nadif Kasri, N., Nadif Kasri, N., Parys, J.B., Bultynck, G.   +10 more
openaire   +4 more sources