Results 21 to 30 of about 17,120 (211)

First Phase of Glucose-Stimulated Insulin Secretion From MIN 6 Cells Does Not Always Require Extracellular Calcium Influx

Journal of Pharmacological Sciences, 2006
.: To demonstrate an involvement of ATP-sensitive potassium (KATP) channel-independent pathways in the first phase of glucose-stimulated insulin secretion (GSIS) from pancreatic β cells, the time course of GSIS from MIN6 cells was analyzed at 30-s sample
Shigeto Makoto, Katsura Masashi, Matsuda Masafumi, Ohkuma Seitaro, Kaku Kohei   +4 more
doaj   +1 more source

Calcium Influx and Release Cooperatively Regulate AChR Patterning and Motor Axon Outgrowth during Neuromuscular Junction Formation

Cell Reports, 2018
Summary: Formation of synapses between motor neurons and muscles is initiated by clustering of acetylcholine receptors (AChRs) in the center of muscle fibers prior to nerve arrival. This AChR patterning is considered to be critically dependent on calcium
Mehmet Mahsum Kaplan, Nasreen Sultana, Ariane Benedetti, Gerald J. Obermair, Nina F. Linde, Symeon Papadopoulos, Anamika Dayal, Manfred Grabner, Bernhard E. Flucher   +8 more
doaj   +1 more source

Calcium Ion as a Second Messenger With Special Reference to Excitation-Contraction Coupling

Journal of Pharmacological Sciences, 2006
.: Calcium ion (Ca2+) plays an important role in stimulus-response reactions of cells as a second messenger. This is done by keeping cytoplasmic Ca2+ concentration low at rest and by mobilizing Ca2+ in response to stimulus, which in turn activates the ...
Makoto Endo
doaj   +1 more source

Physiology and Pharmacology of Ryanodine Receptor Calcium Release Channels

, 2017
Ryanodine receptor (RyR) ion channels are essential for skeletal and cardiac muscle function. Their knockout leads to perinatal death from respiratory and cardiac failure. Acquired changes or mutations in the protein cause debilitating skeletal myopathy and cardiac arrhythmia which can be deadly. Knowledge of the pharmacology of RyR channels is central
Dulhunty, Angela, Board, Philip, Beard, Nicole, Casarotto, Marco   +3 more
openaire   +3 more sources

Calmodulin Binding and Inhibition of Cardiac Muscle Calcium Release Channel (Ryanodine Receptor) [PDF]

Journal of Biological Chemistry, 2001
Metabolically (35)S-labeled calmodulin (CaM) was used to determine the CaM binding properties of the cardiac ryanodine receptor (RyR2) and to identify potential channel domains for CaM binding. In addition, regulation of RyR2 by CaM was assessed in [(3)H]ryanodine binding and single-channel measurements.
D M, Balshaw, L, Xu, N, Yamaguchi, D A, Pasek, G, Meissner   +4 more
openaire   +2 more sources

Adenine dinucleotide second messengers and T-lymphocyte calcium signaling

Frontiers in Immunology, 2013
Calcium signaling is a universal signal transduction mechanism in animal and plant cells. In mammalian T-lymphocytes calcium signaling is essential for activation and re-activation and thus important for a functional immune response.
Insa MA Ernst, Ralf eFliegert, Andreas H Guse   +2 more
doaj   +1 more source

Beneficial effects of dantrolene in the treatment of rhabdomyolysis as a potential late complication associated with COVID-19: a case report

European Journal of Medical Research, 2021
Background Patients with severe COVID-19 have disorders of the respiratory, cardiovascular, coagulation, skeletal muscle, and central nervous systems. These systemic failures may be associated with cytokine release syndrome, characterized by hyperpyrexia,
Nobutaka Chiba, Masakazu Matsuzaki, Takayuki Mawatari, Minori Mizuochi, Atsushi Sakurai, Kosaku Kinoshita   +5 more
doaj   +1 more source

Molecular, Subcellular, and Arrhythmogenic Mechanisms in Genetic RyR2 Disease

Biomolecules, 2022
The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple functional domains with specific roles, and four of these RyR2 protomers are ...
Ewan Douglas Fowler, Spyros Zissimopoulos   +1 more
doaj   +1 more source

Reversible Block of the Calcium Release Channel/Ryanodine Receptor by Protamine, a Heparin Antidote [PDF]

Molecular Biology of the Cell, 2000
Channel activity of the calcium release channel from skeletal muscle, ryanodine receptor type 1, was measured in the presence and absence of protamine sulfate on the cytoplasmic side of the channel. Single-channel activity was measured after incorporating channels into planar lipid bilayers.
P, Koulen, B E, Ehrlich
openaire   +2 more sources

VDAC2-mediated regulation of calcium homeostasis in cardiomyocytes (a review)

Кубанский научный медицинский вестник, 2020
Background. Cardiovascular diseases, especially in association with arrhythmias, remain a prevailing cause of death worldwide. Arrhythmia related to imbalanced Ca2+ homeostasis is triggered by aberrant spontaneous diastolic Ca2+ leak from sarcoplasmic ...
N. V. Schcetinina, A. A. Bolotskaia
doaj   +1 more source