Results 21 to 30 of about 28,867 (291)

Functional calcium release channel formed by the carboxyl-terminal portion of ryanodine receptor

Biophysical Journal, 1997
The ryanodine receptor (RyR) is one of the key proteins involved in excitation-contraction (E-C) coupling in skeletal muscle, where it functions as a Ca2+ release channel in the sarcoplasmic reticulum (SR) membrane. RyR consists of a single polypeptide of approximately 560 kDa normally arranged in a homotetrameric structure, which contains a carboxyl ...
Manjunatha B. Bhat, Jiying Zhao, Hiroshi Takeshima, Jianjie Ma   +3 more
openalex   +3 more sources

FKBP12.6 Deficiency and Defective Calcium Release Channel (Ryanodine Receptor) Function Linked to Exercise-Induced Sudden Cardiac Death [PDF]

Cell, 2003
Xander H.T. Wehrens, Stephan E. Lehnart, Fannie Huang, John A. Vest, Steven Reiken, Peter J. Mohler, Jie Sun, Sílvia Guatimosim, Long‐Sheng Song, Nora Rosemblit, Jeanine D’Armiento, Carlo Napolitano, Mirella Memmi, Silvia G. Priori, W. Jonathan Lederer, Andrew R. Marks   +15 more
openalex   +3 more sources

CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles

eLife, 2023
Activation of voltage-gated calcium channels at presynaptic terminals leads to local increases in calcium and the fusion of synaptic vesicles containing neurotransmitter.
Brian D Mueller, Sean A Merrill, Shigeki Watanabe, Ping Liu, Longgang Niu, Anish Singh, Pablo Maldonado-Catala, Alex Cherry, Matthew S Rich, Malan Silva, Andres Villu Maricq, Zhao-Wen Wang, Erik M Jorgensen   +12 more
doaj   +1 more source

PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor) [PDF]

Cell, 2000
Marx, Steven O, Reiken, Steven, Hisamatsu, Yuji, Jayaraman, Thotalla, Burkhoff, Daniel, Rosemblit, Nora, Marks, Andrew R   +6 more
openaire   +3 more sources

Calcium-release channels: structure and function of IP₃ receptors and ryanodine receptors [PDF]

Physiological Reviews, 2022
Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors (RyRs) and inositol-1,4,5-trisphosphate receptors (IP3Rs), are evolutionarily related and are both activated by cytosolic Ca2+.
Kellie A, Woll, Filip, Van Petegem
openaire   +2 more sources

Magnesium Ions Moderate Calcium-Induced Calcium Release in Cardiac Calcium Release Sites by Binding to Ryanodine Receptor Activation and Inhibition Sites

Frontiers in Physiology, 2022
Ryanodine receptor channels at calcium release sites of cardiac myocytes operate on the principle of calcium-induced calcium release. In vitro experiments revealed competition of Ca2+ and Mg2+ in the activation of ryanodine receptors (RyRs) as well as ...
Bogdan Iaparov, Iuliia Baglaeva, Ivan Zahradník, Alexandra Zahradníková   +3 more
doaj   +1 more source

“Ryanopathies” and RyR2 dysfunctions: can we further decipher them using in vitro human disease models?

Cell Death and Disease, 2021
The regulation of intracellular calcium (Ca2+) homeostasis is fundamental to maintain normal functions in many cell types. The ryanodine receptor (RyR), the largest intracellular calcium release channel located on the sarco/endoplasmic reticulum (SR/ER),
Yvonne Sleiman, Alain Lacampagne, Albano C. Meli   +2 more
doaj   +1 more source

RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays. [PDF]

, 2020
Elevated cytoplasmic [Ca2+] is characteristic in severe skeletal and cardiac myopathies, diabetes, and neurodegeneration, and partly results from increased Ca2+ leak from sarcoplasmic reticulum stores via dysregulated ryanodine receptor (RyR) channels ...
Bers, Donald M, Cornea, Razvan L, Janicek, Kevyn A, Launikonis, Bradley S, Rebbeck, Robyn T, Singh, Daniel P, Thomas, David D   +6 more
core   +2 more sources

Functional characterization of the cardiac ryanodine receptor pore-forming region. [PDF]

PLoS ONE, 2013
Ryanodine receptors are homotetrameric intracellular calcium release channels. The efficiency of these channels is underpinned by exceptional rates of cation translocation through the open channel and this is achieved at the expense of the high degree of
Joanne Euden, Sammy A Mason, Alan J Williams   +2 more
doaj   +1 more source

Single Amino Acid Changes in the Ryanodine Receptor in the Human Population Have Effects In Vivo on Caenorhabditis elegans Neuro-Muscular Function

Frontiers in Genetics, 2020
The ryanodine receptor mediates intracellular calcium ion release with excitation of nerve and muscle cells. Ryanodine receptor missense variants cause a number of myopathologies, such as malignant hyperthermia, and have been linked with various ...
Brittany Graham, Marie-Anne Shaw, Ian A. Hope   +2 more
doaj   +1 more source