Results 11 to 20 of about 17,120 (211)
Functional characterization of the cardiac ryanodine receptor pore-forming region. [PDF]
PLoS ONE, 2013 Ryanodine receptors are homotetrameric intracellular calcium release channels. The efficiency of these channels is underpinned by exceptional rates of cation translocation through the open channel and this is achieved at the expense of the high degree of
Joanne Euden +2 more
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Excitation Contraction Coupling in Hypertrophy and Failing Heart Cells [PDF]
E3S Web of Conferences, 2021 The contraction of the heart is dependent on a process named the excitation-contraction coupling (E-C coupling). In hypertrophy and failing heart models, the expression, phosphorylation and function of key calcium handling proteins involved in E-C ...
Zhou Yiqiu
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Biomolecules, 2022 Contraction of striated muscle is triggered by a massive release of calcium from the sarcoplasmic reticulum (SR) into the cytoplasm. This intracellular calcium release is initiated by membrane depolarization, which is sensed by voltage-gated calcium ...
Stefano Perni
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Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle [PDF]
Nature Medicine, 2009 Duchenne muscular dystrophy is characterized by progressive muscle weakness and early death resulting from dystrophin deficiency. Loss of dystrophin results in disruption of a large dystrophin glycoprotein complex, leading to pathological calcium (Ca2+)-dependent signals that damage muscle cells. We have identified a structural and functional defect in
BELLINGER AM +8 more
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Current clinical application of dantrolene sodium [PDF]
Anesthesia and Pain Medicine, 2023 Dantrolene sodium (DS) was first introduced as an oral antispasmodic drug. However, in 1975, DS was demonstrated to be effective for managing malignant hyperthermia (MH) and was adopted as the primary therapeutic drug after intravenous administration ...
Hong Seuk Yang +5 more
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Journal of Pharmacological Sciences, 2004 Adenosine enhanced intracellular Ca2+ concentrations in astrocytes via A2a adenosine receptors involving protein kinase A (PKA) activation. The Ca2+ rise is inhibited by brefeldin A, an inhibitor of vesicular transport; but not by neomycin and U73122 ...
Tomoyuki Nishizaki
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Snapin, positive regulator of stimulation- induced Ca²⁺ release through RyR, is necessary for HIV-1 replication in T cells. [PDF]
PLoS ONE, 2013 To identify critical host factors necessary for human immunodeficiency virus 1 (HIV-1) replication, large libraries of short-peptide-aptamers were expressed retrovirally.
Shigemi M Kinoshita +3 more
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A Mechanism for Statin-Induced Susceptibility to Myopathy
JACC: Basic to Translational Science, 2019 Summary: This study aimed to identify a mechanism for statin-induced myopathy that explains its prevalence and selectivity for skeletal muscle, and to understand its interaction with moderate exercise.
Sabine Lotteau, PhD +12 more
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Calsequestrin Is an Inhibitor of Skeletal Muscle Ryanodine Receptor Calcium Release Channels [PDF]
Biophysical Journal, 2002 We provide novel evidence that the sarcoplasmic reticulum calcium binding protein, calsequestrin, inhibits native ryanodine receptor calcium release channel activity. Calsequestrin dissociation from junctional face membrane was achieved by increasing luminal (trans) ionic strength from 250 to 500 mM with CsCl or by exposing the luminal side of ...
Beard, Nicole +3 more
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Defining the role of TRPM4 in broadly responsive taste receptor cells
Frontiers in Cellular Neuroscience, 2023 Peripheral taste receptor cells use multiple signaling pathways to transduce taste stimuli into output signals that are sent to the brain. We have previously identified a subpopulation of Type III taste cells that are broadly responsive (BR) and respond ...
Debarghya Dutta Banik, Kathryn F. Medler
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