Results 11 to 20 of about 4,095,708 (243)
The role of ryanodine receptors in development [PDF]
, 2011 PhDCalcium ions (Ca2+) are fundamental to the regulation of many cellular processes; however, the coordination of these signals during embryogenesis is not well understood.
Wu, Houdini Ho-Tin
core +4 more sources
Frontiers in Genetics, 2020 The ryanodine receptor mediates intracellular calcium ion release with excitation of nerve and muscle cells. Ryanodine receptor missense variants cause a number of myopathologies, such as malignant hyperthermia, and have been linked with various ...
Brittany Graham +2 more
doaj +1 more source
Functional characterization of the cardiac ryanodine receptor pore-forming region. [PDF]
PLoS ONE, 2013 Ryanodine receptors are homotetrameric intracellular calcium release channels. The efficiency of these channels is underpinned by exceptional rates of cation translocation through the open channel and this is achieved at the expense of the high degree of
Joanne Euden +2 more
doaj +1 more source
Excitation Contraction Coupling in Hypertrophy and Failing Heart Cells [PDF]
E3S Web of Conferences, 2021 The contraction of the heart is dependent on a process named the excitation-contraction coupling (E-C coupling). In hypertrophy and failing heart models, the expression, phosphorylation and function of key calcium handling proteins involved in E-C ...
Zhou Yiqiu
doaj +1 more source
Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle [PDF]
Nature Medicine, 2009 Duchenne muscular dystrophy is characterized by progressive muscle weakness and early death resulting from dystrophin deficiency. Loss of dystrophin results in disruption of a large dystrophin glycoprotein complex, leading to pathological calcium (Ca2+)-dependent signals that damage muscle cells. We have identified a structural and functional defect in
BELLINGER AM +8 more
openaire +3 more sources
Biomolecules, 2022 Contraction of striated muscle is triggered by a massive release of calcium from the sarcoplasmic reticulum (SR) into the cytoplasm. This intracellular calcium release is initiated by membrane depolarization, which is sensed by voltage-gated calcium ...
Stefano Perni
doaj +1 more source
Current clinical application of dantrolene sodium [PDF]
Anesthesia and Pain Medicine, 2023 Dantrolene sodium (DS) was first introduced as an oral antispasmodic drug. However, in 1975, DS was demonstrated to be effective for managing malignant hyperthermia (MH) and was adopted as the primary therapeutic drug after intravenous administration ...
Hong Seuk Yang +5 more
doaj +1 more source
Journal of Pharmacological Sciences, 2004 Adenosine enhanced intracellular Ca2+ concentrations in astrocytes via A2a adenosine receptors involving protein kinase A (PKA) activation. The Ca2+ rise is inhibited by brefeldin A, an inhibitor of vesicular transport; but not by neomycin and U73122 ...
Tomoyuki Nishizaki
doaj +1 more source
Calcium homeostasis and role of ryanodine receptor type 1 (RyR1) in immune cells [PDF]
, 2010 Ryanodine receptors are intracellular Ca2+ release channels located in the membrane of the Endoplasmatic/Sarcoplasmatic Reticulum. Ryanodine receptor 1 isoform is preferentially expressed in skeletal muscle where it is responsible for release of Ca2 ...
Vukcevic, Mirko
core +1 more source
Snapin, positive regulator of stimulation- induced Ca²⁺ release through RyR, is necessary for HIV-1 replication in T cells. [PDF]
PLoS ONE, 2013 To identify critical host factors necessary for human immunodeficiency virus 1 (HIV-1) replication, large libraries of short-peptide-aptamers were expressed retrovirally.
Shigemi M Kinoshita +3 more
doaj +1 more source