Results 11 to 20 of about 32,504 (219)

Ryanodine receptor channelopathies [PDF]

Pflügers Archiv - European Journal of Physiology, 2010
Ryanodine receptors (RyR) are intracellular Ca2+-permeable channels that provide the sarcoplasmic reticulum Ca2+ release required for skeletal and cardiac muscle contractions. RyR1 underlies skeletal muscle contraction, and RyR2 fulfills this role in cardiac muscle.
Matthew J, Betzenhauser, Andrew R, Marks
openaire   +2 more sources

Activating ryanodine receptor improves isoflurane-induced cognitive dysfunction

Brain Research Bulletin, 2023
Background: Postoperative cognitive dysfunction (POCD) is characterized by impaired learning and memory. 6 h duration isoflurane anesthesia is an important factor to induce POCD, and the dysfunction of ryanodine receptor (RyR) in the hippocampus may be ...
Binwen Liu, Xurui Zhu, Qingyun Zhou, Yan Su, Yue Qian, Zhengliang Ma, Xiaoping Gu, Tianjiao Xia   +7 more
doaj   +1 more source

Single Amino Acid Changes in the Ryanodine Receptor in the Human Population Have Effects In Vivo on Caenorhabditis elegans Neuro-Muscular Function

Frontiers in Genetics, 2020
The ryanodine receptor mediates intracellular calcium ion release with excitation of nerve and muscle cells. Ryanodine receptor missense variants cause a number of myopathologies, such as malignant hyperthermia, and have been linked with various ...
Brittany Graham, Marie-Anne Shaw, Ian A. Hope   +2 more
doaj   +1 more source

Hippocampus anatomical structure and distribution of agrin proteoglycan and ryanodine receptor expression boost bird food caching behavior

The European Zoological Journal, 2021
Feeding habitats and behavior are connected with various environmental conditions and anatomical structures of the hippocampus, altogether with proteins expression level that may enhance their cognitive memory abilities.
I. M. Hamza, Y. M. Mobarak, H. S. Hafez
doaj   +1 more source

Ryanodine Receptor Adaptation [PDF]

The Journal of General Physiology, 2000
In the heart, depolarization during the action potential activates voltage-dependent Ca2+ channels that mediate a small, localized Ca2+ influx (ICa). This small Ca2+ signal activates specialized Ca2+ release channels, the ryanodine receptors (RyRs), in the sarcoplasmic reticulum (SR).
M, Fill, A, Zahradníková, C A, Villalba-Galea, I, Zahradník, A L, Escobar, S, Györke   +5 more
openaire   +2 more sources

The link between abnormalities of calcium handling proteins and catecholaminergic polymorphic ventricular tachycardia

Tzu Chi Medical Journal, 2021
Catecholaminergic polymorphic ventricular tachycardia (CPVT), a rare autosomal dominant or recessive disease, usually results in syncope or sudden cardiac death. Most CPVT patients do not show abnormal cardiac structure and electrocardiogram features and
Ding-Jyun Lin, Wen-Sen Lee, Yu-Chung Chien, Tsung-Yu Chen, Kun-Ta Yang   +4 more
doaj   +1 more source

Cell Deformation at the Air-Liquid Interface Evokes Intracellular Ca2+ Increase and ATP Release in Cultured Rat Urothelial Cells

Frontiers in Physiology, 2021
Urothelial cells have been implicated in bladder mechanosensory transduction, and thus, initiation of the micturition reflex. Cell deformation caused by tension forces at an air-liquid interface (ALI) can induce an increase in intracellular Ca2 ...
Jiliang Wen, Jiliang Wen, Zhenghao Chen, Mengmeng Zhao, Shulu Zu, Shengtian Zhao, Shaoyong Wang, Xiulin Zhang   +7 more
doaj   +1 more source

Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory

Communications Biology, 2022
A mouse model containing a GFP-tagged ryanodine receptor 2 (RyR2) has shed light on the precise subcellular localization of hippocampal RyR2 and mechanisms underlying neuronal excitability, learning, and memory.
Florian Hiess, Jinjing Yao, Zhenpeng Song, Bo Sun, Zizhen Zhang, Junting Huang, Lina Chen, Adam Institoris, John Paul Estillore, Ruiwu Wang, Henk E. D. J. ter Keurs, Peter K. Stys, Grant R. Gordon, Gerald W. Zamponi, Anutosh Ganguly, S. R. Wayne Chen   +15 more
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Homer and the ryanodine receptor

European Biophysics Journal, 2009
Homer proteins have recently been identified as novel high-affinity ligands that modulate ryanodine receptor (RyR) Ca(2+) release channels in heart and skeletal muscle, through an EVH1 domain which binds to proline-rich regions in target proteins. Many Homer proteins can also self-associate through a coiled-coil domain that allows their multimerisation.
Pouliquin, Pierre, Dulhunty, Angela
openaire   +3 more sources

Chronic dantrolene treatment attenuates cardiac dysfunction and reduces atrial fibrillation inducibility in a rat myocardial infarction heart failure modelKey Findings

Heart Rhythm O2, 2020
Background: Cardiac ryanodine receptor 2 (RyR2) dysfunction and elevated diastolic Ca2+ leak have been linked to arrhythmogenesis not only in inherited arrhythmia syndromes but also in acquired forms of heart disease including heart failure (HF) and ...
Colleen Nofi, DO, Kuo Zhang, MD, PhD, Yi-Da Tang, MD, PhD, Ying Li, BS, Allan Migirov, MBS, Kaie Ojamaa, PhD, A. Martin Gerdes, PhD, Youhua Zhang, MD, PhD   +7 more
doaj   +1 more source