Results 41 to 50 of about 2,688,953 (298)

Estradiol-Mediated Axogenesis of Hypothalamic Neurons Requires ERK1/2 and Ryanodine Receptors-Dependent Intracellular Ca2+ Rise in Male Rats

Frontiers in Cellular Neuroscience, 2019
17β-estradiol (E2) induces axonal growth through extracellular signal-regulated kinase 1 and 2 (ERK1/2)-MAPK cascade in hypothalamic neurons of male rat embryos in vitro, but the mechanism that initiates these events is poorly understood.
Lucas E. Cabrera Zapata, Mariana Bollo, María Julia Cambiasso, María Julia Cambiasso   +3 more
doaj   +1 more source

Rapid selection for resistance to diamide insecticides in Plutella xylostella via specific amino acid polymorphisms in the ryanodine receptor

Neurotoxicology, 2017
Highlights • Baseline susceptibility of Plutella xylostella to diamide insecticides collated.• Instances of diamide resistance in P. xylostella summarized.• Diamide insecticide specificity for the insect ryanodine receptor highlighted.• Efforts to ...
Bartlomiej J. Troczka, M. Williamson, L. Field, T. Davies   +3 more
semanticscholar   +1 more source

Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity

Nature Communications, 2021
Ryanodine receptor type 1 (RyR1) are involved in skeletal muscle contraction. Here, the authors show that a transient calcium leak in response to exercise-induced post translational modifications of RyR1 causes mitochondrial remodeling to improve ...
Nadège Zanou, Haikel Dridi, Steven Reiken, Tanes Imamura de Lima, Chris Donnelly, Umberto De Marchi, Manuele Ferrini, Jeremy Vidal, Leah Sittenfeld, Jerome N. Feige, Pablo M. Garcia-Roves, Isabel C. Lopez-Mejia, Andrew R. Marks, Johan Auwerx, Bengt Kayser, Nicolas Place   +15 more
doaj   +1 more source

Junctional sarcoplasmic reticulum motility in adult mouse ventricular myocytes. [PDF]

, 2020
Excitation-contraction (EC) coupling is the coordinated process by which an action potential triggers cardiac myocyte contraction. EC coupling is initiated in dyads where the junctional sarcoplasmic reticulum (jSR) is in tight proximity to the sarcolemma
de la Mata, Ana, Drum, Benjamin M, Grainger, Nathan, Grainger, Nathan, Santana, L Fernando, Yuan, Can   +5 more
core   +2 more sources

Influence of Lipid Mimetics on Gating of Ryanodine Receptor.

Structure, 2018
Understanding gating principles of ion channels at high resolution is of great importance. Here we investigate the conformational transition from closed to open state in ryanodine receptor 1 (RyR1) reconstituted into lipid nanodiscs.
K. Willegems, R. Efremov
semanticscholar   +1 more source

Presenilin-ryanodine receptor connection [PDF]

Proceedings of the National Academy of Sciences, 2013
The Presenilins (PS) gene family is composed of two members: PS1 and PS2. Mutations in PSs are linked to familial Alzheimer's disease (FAD) (1). PSs are the catalytic subunits of the γ-secretase multimolecular complex, which mediates the intramembranous cleavage of many type I membrane proteins, including amyloid precursor protein (APP) and Notch (2, 3)
Luciano, D'Adamio, Pablo E, Castillo
openaire   +2 more sources

Role of Inositol-1,4,5-Trisphosphate Receptor in the Regulation of Calcium Transients in Neonatal Rat Ventricular Myocytes

Journal of Pharmacological Sciences, 2014
This study determined the regulatory effect of inositol 1,4,5-trisphosphate receptors (IP3Rs) on the basal Ca2+ transients in cardiomyocytes. In cultured neonatal rat ventricular myocytes (NRVMs) at different densities, we used confocal microscopy to ...
Zheng Zeng, Heping Zhang, Na Lin, Man Kang, Yuanyuan Zheng, Chen Li, Pingxiang Xu, Yongquan Wu, Dali Luo   +8 more
doaj   +1 more source

The possibility of positive selection for both F18(+) Escherichia coli and stress resistant pigs opens new perspectives for pig breeding [PDF]

, 2007
International ...
Coddens, Annelies, Cox, Eric, Duchateau, Luc, Goddeeris, Bruno, GOYVAERTS, E, MIRY, C, MULINGE, M, Verdonck, Frank   +7 more
core   +3 more sources

Ryanodine Receptors in Liver [PDF]

Journal of Biological Chemistry, 2006
The ryanodine receptor has been mainly regarded as the Ca2+ release channel from sarcoplasmic reticulum controlling skeletal and cardiac muscle contraction. However, many studies have shown that it is widely expressed, with functions not restricted to muscular contraction. This study examined whether ryanodine receptor plays a role in calcium signaling
Nicola, Pierobon, Dominique C, Renard-Rooney, Lawrence D, Gaspers, Andrew P, Thomas   +3 more
openaire   +2 more sources

CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles

eLife, 2023
Activation of voltage-gated calcium channels at presynaptic terminals leads to local increases in calcium and the fusion of synaptic vesicles containing neurotransmitter.
Brian D Mueller, Sean A Merrill, Shigeki Watanabe, Ping Liu, Longgang Niu, Anish Singh, Pablo Maldonado-Catala, Alex Cherry, Matthew S Rich, Malan Silva, Andres Villu Maricq, Zhao-Wen Wang, Erik M Jorgensen   +12 more
doaj   +1 more source