Results 41 to 50 of about 31,472 (217)

The ryanodine receptor microdomain in cardiomyocytes

Cell Calcium, 2023
The ryanodine receptor type 2 (RyR) is a key player in Ca2+ handling during excitation-contraction coupling. During each heartbeat, RyR channels are responsible for linking the action potential with the contractile machinery of the cardiomyocyte by releasing Ca2+ from the sarcoplasmic reticulum.
Dries, Eef, Gilbert, Guillaume, Roderick, H. Llewelyn, Sipido, Karin R.   +3 more
openaire   +4 more sources

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

Differential Downregulation of β1‐Adrenergic Receptor Signaling in the Heart

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Chronic sympathetic stimulation drives desensitization and downregulation of β1 adrenergic receptor (β1AR) in heart failure. We aim to explore the differential downregulation subcellular pools of β1AR signaling in the heart.
Bing Xu, Sherif Bahriz, Victoria R. Salemme, Ying Wang, Chaoqun Zhu, Meimi Zhao, Yang K. Xiang   +6 more
doaj   +1 more source

Regulation of Ryanodine Receptors in the Heart [PDF]

Circulation Research, 2007
See related article, pages 819–829 In response to exercise or other stresses, catecholamines are released into the circulation and within the heart. Catecholaminergic stimulation of β1-adrenergic receptors (β1ARs) in the heart increases heart rate (chronotropy) and contractility (inotropy), resulting in increased cardiac output during acute ...
Lehnart, Stephan Elmar, Marks, Andrew R.
openaire   +2 more sources

Sacubitril/valsartan preserves regional cardiac function following myocardial infarction in rats

ESC Heart Failure, Volume 12, Issue 2, Page 1304-1315, April 2025.
Parts of the figure were drawn by using pictures from Servier Medical Art. Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/). Abstract Aims Sacubitril/valsartan (Sac/Val) is used for treatment of heart failure. The effect of Sac/Val on regional dysfunction
Einar Sjaastad Nordén, Bård Andre Bendiksen, Kaja Knudsen Bergo, Emil Knut Stenersen Espe, Gary McGinley, Almira Hasic, Ida Marie Hauge‐Iversen, Hege Katrin Ugland, Xin Shen, Michael Frisk, Nishani S. Mabotuwana, William E. Louch, Rizwan I. Hussain, Lili Zhang, Ivar Sjaastad, Alessandro Cataliotti, Geir Christensen   +16 more
wiley   +1 more source

FKBP12 Depletion Leads to Loss of Sarcoplasmic Reticulum Ca2+ Stores in Rat Vas Deferens

Journal of Pharmacological Sciences, 2009
The immunophilin 12-kDa FK506 binding protein (FKBP12) stabilizes intracellular Ca2+ release channel (CRC) activity in different tissues. In this work, the presence of FKBP12 in rat vas deferens (RVD) and its possible contribution to RVD function was ...
Christianne B.V. Scaramello, Humberto Muzi-Filho, Gisele Zapata-Sudo, Roberto T. Sudo, Valéria do M.N. Cunha   +4 more
doaj   +1 more source

Dependency of calcium alternans on ryanodine receptor refractoriness. [PDF]

PLoS ONE, 2013
BACKGROUND: Rapid pacing rates induce alternations in the cytosolic calcium concentration caused by fluctuations in calcium released from the sarcoplasmic reticulum (SR).
Enric Alvarez-Lacalle, Inma R Cantalapiedra, Angelina Peñaranda, Juan Cinca, Leif Hove-Madsen, Blas Echebarria   +5 more
doaj   +1 more source

Extra Virgin Olive Oil Phenols Vasodilate Rat Mesenteric Resistance Artery via Phospholipase C (PLC)-Calcium Microdomains-Potassium Channels (BK_Ca) Signals

Biomolecules, 2021
Recent evidence suggests that the reason Extra Virgin Olive Oil (EVOO) lowers blood pressure and reduces the risk of developing hypertension is partly due to minor components of EVOO, such as phenols. However, little is still known about the mechanism(s)
Rossana D’Agostino, Laura Barberio, Mariacarmela Gatto, Teresa Tropea, Maria De Luca, Maurizio Mandalà   +5 more
doaj   +1 more source

The structural biology of ryanodine receptors [PDF]

Science China Life Sciences, 2011
Ryanodine receptors are ion channels that allow for the release of Ca(2+) from the endoplasmic or sarcoplasmic reticulum. They are expressed in many different cell types but are best known for their predominance in skeletal and cardiac myocytes, where they are directly involved in excitation-contraction coupling. With molecular weights exceeding 2 MDa,
Kimlicka, Lynn, Van Petegem, Filip
openaire   +2 more sources

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source