Results 51 to 60 of about 2,688,953 (298)

Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology. [PDF]

, 2009
The cause(s) of sporadic Alzheimer's disease (sAD) are complex and currently poorly understood. They likely result from a combination of genetic, environmental, proteomic and lipidomic factors that crucially occur only in the aged brain.
Green, Kim N
core   +1 more source

Single-particle cryo-EM of the ryanodine receptor channel

European Journal of Translational Myology, 2015
Ryanodine receptors (RyRs) are tetrameric ligand-gated Ca2+ release channels that are responsible for the increase of cytosolic Ca2+ concentration leading to muscle contraction.
Mariah R. Baker, Guizhen Fan, Irina I. Serysheva   +2 more
doaj   +1 more source

Loss of dysferlin or myoferlin results in differential defects in excitation–contraction coupling in mouse skeletal muscle

Scientific Reports, 2021
Muscular dystrophies are disorders characterized by progressive muscle loss and weakness that are both genotypically and phenotypically heterogenous. Progression of muscle disease arises from impaired regeneration, plasma membrane instability, defective ...
David Y. Barefield, Jordan J. Sell, Ibrahim Tahtah, Samuel D. Kearns, Elizabeth M. McNally, Alexis R. Demonbreun   +5 more
doaj   +1 more source

Marked Sexual Dimorphism in the Role of the Ryanodine Receptor in a Model of Pain Chronification in the Rat

Scientific Reports, 2016
Hyperalgesic priming, an estrogen dependent model of the transition to chronic pain, produced by agonists at receptors that activate protein kinase C epsilon (PKCε), occurs in male but not in female rats.
L. Ferrari, E. Khomula, Dionéia Araldi, J. Levine   +3 more
semanticscholar   +1 more source

MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling

Nature Communications, 2020
TRIM proteins are known to play critical roles in the context of viral infection. Here the authors establish MG53 (TRIM72) suppresses IFN and inflammation by modulation of ryanodine receptor related intracellular calcium induction.
Matthew Sermersheim, Adam D. Kenney, Pei-Hui Lin, Temet M. McMichael, Chuanxi Cai, Kristyn Gumpper, T. M. Ayodele Adesanya, Haichang Li, Xinyu Zhou, Ki-Ho Park, Jacob S. Yount, Jianjie Ma   +11 more
doaj   +1 more source

Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling

iScience, 2020
Summary: This study shows that multiple modes of mitochondrial stress generated by partial mtDNA depletion or cytochrome c oxidase disruption cause ryanodine receptor channel (RyR) dysregulation, which instigates the release of Ca2+ in the cytoplasm of ...
Anindya Roy Chowdhury, Satish Srinivasan, György Csordás, György Hajnóczky, Narayan G. Avadhani   +4 more
doaj   +1 more source

Targeting RyR Activity Boosts Antisense Exon 44 and 45 Skipping in Human DMD Skeletal or Cardiac Muscle Culture Models. [PDF]

, 2019
Systemic delivery of antisense oligonucleotides (AO) for DMD exon skipping has proven effective for reframing DMD mRNA, rescuing dystrophin expression, and slowing disease progression in animal models.
Barthélémy, Florian, Douine, Emilie D, Hsu, Christopher, Marcantonio, Eugene E, Miceli, M Carrie, Nelson, Stanley F, Wang, Richard T   +6 more
core   +1 more source

Structure–function relationships of peptides forming the calcin family of ryanodine receptor ligands

The Journal of General Physiology, 2016
Calcins are a new and expanding family of ryanodine receptor agonists found in scorpion venom. Xiao and colleagues characterize the structure–function relationships of all known calcins and show both similarities and differences in their form and ...
Liang Xiao, G. Gurrola, Jing Zhang, C. Valdivia, M. SanMartín, F. Zamudio, Liming Zhang, L. Possani, H. Valdivia   +8 more
semanticscholar   +1 more source

Human cardiomyocyte calcium handling and transverse tubules in mid-stage of post-myocardial-infarction heart failure [PDF]

, 2018
Aims: Cellular processes in the heart rely mainly on studies from experimental animal models or explanted hearts from patients with terminal end-stage heart failure (HF).
Condorelli, Gianluigi, Contu, Riccardo, Ellingsen, Øyvind, Haaverstad, Rune, Høydal, Morten Andre, Karevold, Asbjørn, Kemi, Ole J., Kirkeby-Garstad, Idar, Smith, Godfrey L., Stølen, Tomas L., Wahba, Alexander, Wiseth, Rune, Wisløff, Ulrik   +12 more
core   +2 more sources

Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function

Proceedings of the National Academy of Sciences of the United States of America, 2015
Significance Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmogenic syndrome characterized by life-threatening cardiac arrhythmias triggered by physical exercise or emotional stress.
Yan Ting Zhao, C. Valdivia, G. Gurrola, G. Gurrola, Patricia P. Powers, B. C. Willis, R. Moss, J. Jalife, H. Valdivia   +8 more
semanticscholar   +1 more source