Results 31 to 40 of about 31,472 (217)

Single-particle cryo-EM of the ryanodine receptor channel

European Journal of Translational Myology, 2015
Ryanodine receptors (RyRs) are tetrameric ligand-gated Ca2+ release channels that are responsible for the increase of cytosolic Ca2+ concentration leading to muscle contraction.
Mariah R. Baker, Guizhen Fan, Irina I. Serysheva   +2 more
doaj   +1 more source

CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles

eLife, 2023
Activation of voltage-gated calcium channels at presynaptic terminals leads to local increases in calcium and the fusion of synaptic vesicles containing neurotransmitter.
Brian D Mueller, Sean A Merrill, Shigeki Watanabe, Ping Liu, Longgang Niu, Anish Singh, Pablo Maldonado-Catala, Alex Cherry, Matthew S Rich, Malan Silva, Andres Villu Maricq, Zhao-Wen Wang, Erik M Jorgensen   +12 more
doaj   +1 more source

Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling

iScience, 2020
Summary: This study shows that multiple modes of mitochondrial stress generated by partial mtDNA depletion or cytochrome c oxidase disruption cause ryanodine receptor channel (RyR) dysregulation, which instigates the release of Ca2+ in the cytoplasm of ...
Anindya Roy Chowdhury, Satish Srinivasan, György Csordás, György Hajnóczky, Narayan G. Avadhani   +4 more
doaj   +1 more source

Loss of dysferlin or myoferlin results in differential defects in excitation–contraction coupling in mouse skeletal muscle

Scientific Reports, 2021
Muscular dystrophies are disorders characterized by progressive muscle loss and weakness that are both genotypically and phenotypically heterogenous. Progression of muscle disease arises from impaired regeneration, plasma membrane instability, defective ...
David Y. Barefield, Jordan J. Sell, Ibrahim Tahtah, Samuel D. Kearns, Elizabeth M. McNally, Alexis R. Demonbreun   +5 more
doaj   +1 more source

MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling

Nature Communications, 2020
TRIM proteins are known to play critical roles in the context of viral infection. Here the authors establish MG53 (TRIM72) suppresses IFN and inflammation by modulation of ryanodine receptor related intracellular calcium induction.
Matthew Sermersheim, Adam D. Kenney, Pei-Hui Lin, Temet M. McMichael, Chuanxi Cai, Kristyn Gumpper, T. M. Ayodele Adesanya, Haichang Li, Xinyu Zhou, Ki-Ho Park, Jacob S. Yount, Jianjie Ma   +11 more
doaj   +1 more source

Kinetics and mapping of Ca-driven calmodulin conformations on skeletal and cardiac muscle ryanodine receptors

Nature Communications
Calmodulin transduces [Ca2+] information regulating the rhythmic Ca2+ cycling between the sarcoplasmic reticulum and cytoplasm during contraction and relaxation in cardiac and skeletal muscle.
Robyn T. Rebbeck, Bengt Svensson, Jingyan Zhang, Montserrat Samsó, David D. Thomas, Donald M. Bers, Razvan L. Cornea   +6 more
doaj   +1 more source

Additive‐Manufactured, Multifunctional Bioreactor Technology for Dynamic Culture of 3D Bioprinted Tissue Models

Advanced Materials Technologies, EarlyView.
We introduce an additively manufactured bioreactor with a perfusion flow system and integrated temperature and pH sensors for skeletal muscle tissue biofabrication. The bioreactor's performance was evaluated by assessing the viability, spreading of the myoblast cells in a printed scaffold, and contraction of the isolated murine musculi interossei ...
Lys Sprenger, Johann Schorzmann, Hsuan‐Heng Lu, Muhammad Osama, Julian Bauer, Michael Haug, Oliver Friedrich, Aldo R. Boccaccini, Frank Döpper, Sahar Salehi   +9 more
wiley   +1 more source

Calcium-induced calcium release and type 3 ryanodine receptors modulate the slow afterhyperpolarising current, sIAHP, and its potentiation in hippocampal pyramidal neurons.

PLoS ONE, 2020
The slow afterhyperpolarising current, sIAHP, is a Ca2+-dependent current that plays an important role in the late phase of spike frequency adaptation.
Angelo Tedoldi, Petra Ludwig, Gianluca Fulgenzi, Hiroshi Takeshima, Paola Pedarzani, Martin Stocker   +5 more
doaj   +1 more source

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

Presenilin-ryanodine receptor connection [PDF]

Proceedings of the National Academy of Sciences, 2013
The Presenilins (PS) gene family is composed of two members: PS1 and PS2. Mutations in PSs are linked to familial Alzheimer's disease (FAD) (1). PSs are the catalytic subunits of the γ-secretase multimolecular complex, which mediates the intramembranous cleavage of many type I membrane proteins, including amyloid precursor protein (APP) and Notch (2, 3)
Luciano, D'Adamio, Pablo E, Castillo
openaire   +2 more sources