Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia [PDF]
, 2015 Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a difficult-to-diagnose cause of sudden cardiac death (SCD). We identified a family of 1400 individuals with multiple cases of CPVT, including 36 SCDs during youth.
Allegue, Catarina +12 more
core +3 more sources
Ryanodine Receptor 1-Related Myopathies: Diagnostic and Therapeutic Approaches
Neurotherapeutics, 2018 Ryanodine receptor type 1-related myopathies (RYR1-RM) are the most common class of congenital myopathies. Historically, RYR1-RM classification and diagnosis have been guided by histopathologic findings on muscle biopsy.
Tokunbor A. Lawal, J. Todd, K. Meilleur
semanticscholar +1 more source
Nature Communications, 2022 Ryanodine receptor 2 (RyR2) is a Ca2+ release channel essential for cardiac excitation-contraction coupling. Here, the authors use structural and functional analysis to reveal RyR2 gating mechanism and its alterations by pathogenic mutations.
Takuya Kobayashi +8 more
doaj +1 more source
Mechanisms of modulation of brain microvascular endothelial cells function by thrombin. [PDF]
, 2017 Brain microvascular endothelial cells are a critical component of the blood-brain barrier. They form a tight monolayer which is essential for maintaining the brain homeostasis.
Abood, Mary E. +4 more
core +2 more sources
The structural basis of ryanodine receptor ion channel function
The Journal of General Physiology, 2017 Large-conductance Ca2+ release channels known as ryanodine receptors (RyRs) mediate the release of Ca2+ from an intracellular membrane compartment, the endo/sarcoplasmic reticulum.
G. Meissner
semanticscholar +1 more source
Journal of Pharmacological Sciences, 2004 Adenosine enhanced intracellular Ca2+ concentrations in astrocytes via A2a adenosine receptors involving protein kinase A (PKA) activation. The Ca2+ rise is inhibited by brefeldin A, an inhibitor of vesicular transport; but not by neomycin and U73122 ...
Tomoyuki Nishizaki
doaj +1 more source
Cardiac Specific Gene Expression Changes in Long Term Culture of Murine Mesenchymal Stem Cells [PDF]
, 2011 Murine MSCs are a readily available source of adult stem cells enabling extensive in vitro study of this cell population. MSCs have been described as multipotent, and have been proven capable of differentiation into several connective tissue types ...
Argyle, D.J. +6 more
core +2 more sources
A bivalent remipede toxin promotes calcium release via ryanodine receptor activation
Nature Communications, 2023 Insect toxins with tandem repeats of neurotoxin domains have been found with enhanced receptor avidity. Here, the authors describe a bivalent toxin from remipede venom that targets ryanodine receptors, a rare target for animal venoms.
Michael J. Maxwell +13 more
doaj +1 more source
Interval training normalizes cCardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy [PDF]
, 2009 In the present study we explored the mechanisms behind excitation-contraction (EC)-coupling defects in cardiomyocytes from mice with type-2 diabetes (db/db), and determined whether 13-weeks of aerobic interval training could restore cardiomyocyte Ca2 ...
Aasum, E. +10 more
core +2 more sources
Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes
eLife, 2018 Reduced cardiac contractility during heart failure (HF) is linked to impaired Ca2+ release from Ryanodine Receptors (RyRs). We investigated whether this deficit can be traced to nanoscale RyR reorganization.
Terje R. Kolstad +12 more
semanticscholar +1 more source