Results 31 to 40 of about 32,504 (219)

Old dog, new trick: Charybdotoxin as a novel ryanodine receptor blocker. [PDF]

J Physiol
Abstract figure legend The peptide toxin charybdotoxin (ChTx) from the scorpion Leiurus quinquestriatus was tested on single‐channel currents of the ryanodine receptor incorporated into planar lipid bilayers. The structure–function relationship of ChTx was investigated using toxin variants generated by isosteric substitutions of the basic amino acids ...
Magyar ZÉ, Hevesi J, Mészáros F, Bozsó Z, Szolomájer J, Tóth G, Panyi G, Enyedi P, Varga Z, Pethő Z, Almássy J.   +10 more
europepmc   +2 more sources

Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling

iScience, 2020
Summary: This study shows that multiple modes of mitochondrial stress generated by partial mtDNA depletion or cytochrome c oxidase disruption cause ryanodine receptor channel (RyR) dysregulation, which instigates the release of Ca2+ in the cytoplasm of ...
Anindya Roy Chowdhury, Satish Srinivasan, György Csordás, György Hajnóczky, Narayan G. Avadhani   +4 more
doaj   +1 more source

Loss of dysferlin or myoferlin results in differential defects in excitation–contraction coupling in mouse skeletal muscle

Scientific Reports, 2021
Muscular dystrophies are disorders characterized by progressive muscle loss and weakness that are both genotypically and phenotypically heterogenous. Progression of muscle disease arises from impaired regeneration, plasma membrane instability, defective ...
David Y. Barefield, Jordan J. Sell, Ibrahim Tahtah, Samuel D. Kearns, Elizabeth M. McNally, Alexis R. Demonbreun   +5 more
doaj   +1 more source

CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles

eLife, 2023
Activation of voltage-gated calcium channels at presynaptic terminals leads to local increases in calcium and the fusion of synaptic vesicles containing neurotransmitter.
Brian D Mueller, Sean A Merrill, Shigeki Watanabe, Ping Liu, Longgang Niu, Anish Singh, Pablo Maldonado-Catala, Alex Cherry, Matthew S Rich, Malan Silva, Andres Villu Maricq, Zhao-Wen Wang, Erik M Jorgensen   +12 more
doaj   +1 more source

MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling

Nature Communications, 2020
TRIM proteins are known to play critical roles in the context of viral infection. Here the authors establish MG53 (TRIM72) suppresses IFN and inflammation by modulation of ryanodine receptor related intracellular calcium induction.
Matthew Sermersheim, Adam D. Kenney, Pei-Hui Lin, Temet M. McMichael, Chuanxi Cai, Kristyn Gumpper, T. M. Ayodele Adesanya, Haichang Li, Xinyu Zhou, Ki-Ho Park, Jacob S. Yount, Jianjie Ma   +11 more
doaj   +1 more source

Kinetics and mapping of Ca-driven calmodulin conformations on skeletal and cardiac muscle ryanodine receptors

Nature Communications
Calmodulin transduces [Ca2+] information regulating the rhythmic Ca2+ cycling between the sarcoplasmic reticulum and cytoplasm during contraction and relaxation in cardiac and skeletal muscle.
Robyn T. Rebbeck, Bengt Svensson, Jingyan Zhang, Montserrat Samsó, David D. Thomas, Donald M. Bers, Razvan L. Cornea   +6 more
doaj   +1 more source

Calcium-induced calcium release and type 3 ryanodine receptors modulate the slow afterhyperpolarising current, sIAHP, and its potentiation in hippocampal pyramidal neurons.

PLoS ONE, 2020
The slow afterhyperpolarising current, sIAHP, is a Ca2+-dependent current that plays an important role in the late phase of spike frequency adaptation.
Angelo Tedoldi, Petra Ludwig, Gianluca Fulgenzi, Hiroshi Takeshima, Paola Pedarzani, Martin Stocker   +5 more
doaj   +1 more source

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Regulation of Ryanodine Receptors in the Heart [PDF]

Circulation Research, 2007
See related article, pages 819–829 In response to exercise or other stresses, catecholamines are released into the circulation and within the heart. Catecholaminergic stimulation of β1-adrenergic receptors (β1ARs) in the heart increases heart rate (chronotropy) and contractility (inotropy), resulting in increased cardiac output during acute ...
Lehnart, Stephan Elmar, Marks, Andrew R.
openaire   +2 more sources