Glucose-Dependent Insulin Secretion in Pancreatic β-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors. [PDF]
PLoS ONE, 2015 Glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells requires an increase in intracellular free Ca2+ concentration ([Ca2+]). Glucose uptake into β-cells promotes Ca2+ influx and reactive oxygen species (ROS) generation. In other cell types,
Paola Llanos +5 more
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Phosphorylation of Ryanodine Receptors
Biological Research, 2004 Both cardiac and skeletal muscle ryanodine receptors (RyRs) are parts of large complexes that include a number of kinases and phosphatases. These RyRs have several potential phosphorylation sites in their cytoplasmic domains, but the functional ...
CRISTINA I DANILA, SUSAN L HAMILTON
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Journal of General Physiology, 2014 Numerical modeling indicates that hierarchical clustering of ryanodine receptors in cells of the sinoatrial node is crucial to the calcium clock and thereby to regulation of heart rate.
VÍCTOR A Maltsev +2 more
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Calmodulin variants associated with congenital arrhythmia impair selectivity for ryanodine receptors [PDF]
Frontiers in Molecular Biosciences, 2023 Among its many molecular targets, the ubiquitous calcium sensor protein calmodulin (CaM) recognizes and regulates the activity of ryanodine receptors type 1 (RyR1) and 2 (RyR2), mainly expressed in skeletal and cardiac muscle, respectively.
Giuditta Dal Cortivo +3 more
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Ryanodine Receptors in Autophagy: Implications for Neurodegenerative Diseases? [PDF]
Frontiers in Cellular Neuroscience, 2018 Intracellular Ca2+ signaling is important in the regulation of several cellular processes including autophagy. The endoplasmic reticulum (ER) is the main and largest intracellular Ca2+ store.
Tim Vervliet
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The structural biology of ryanodine receptors [PDF]
Science China Life Sciences, 2011 Ryanodine receptors are ion channels that allow for the release of Ca2+ from the endoplasmic or sarcoplasmic reticulum. They are expressed in many different cell types but are best known for their predominance in skeletal and cardiac myocytes, where they
Lynn Kimlicka, F. Petegem
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The Role of Ryanodine Receptors in Regulating Neuronal Activity and Its Connection to the Development of Alzheimer’s Disease [PDF]
Cells, 2023 Andrea Marcantoni +2 more
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Effects of rogue ryanodine receptors on Ca2+ sparks in cardiac myocytes [PDF]
Royal Society Open Science, 2018 Ca2+ sparks and Ca2+ quarks, arising from clustered and rogue ryanodine receptors (RyRs), are significant Ca2+ release events from the junctional sarcoplasmic reticulum (JSR).
Xudong Chen +3 more
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Ryanodine receptors are part of the myospryn complex in cardiac muscle [PDF]
Scientific Reports, 2017 The Cardiomyopathy–associated gene 5 (Cmya5) encodes myospryn, a large tripartite motif (TRIM)-related protein found predominantly in cardiac and skeletal muscle. Cmya5 is an expression biomarker for a number of diseases affecting striated muscle and may
Matthew A. Benson +9 more
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Ryanodine Receptors in Islet Cell Function: Calcium Signaling, Hormone Secretion, and Diabetes [PDF]
CellsMd Shahidul Islam
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