Results 31 to 40 of about 2,684,234 (246)
Tzu Chi Medical Journal, 2021 Catecholaminergic polymorphic ventricular tachycardia (CPVT), a rare autosomal dominant or recessive disease, usually results in syncope or sudden cardiac death. Most CPVT patients do not show abnormal cardiac structure and electrocardiogram features and
Ding-Jyun Lin +4 more
doaj +1 more source
Homer and the ryanodine receptor
European Biophysics Journal, 2009 Homer proteins have recently been identified as novel high-affinity ligands that modulate ryanodine receptor (RyR) Ca(2+) release channels in heart and skeletal muscle, through an EVH1 domain which binds to proline-rich regions in target proteins. Many Homer proteins can also self-associate through a coiled-coil domain that allows their multimerisation.
Pouliquin, Pierre, Dulhunty, Angela
openaire +3 more sources
Functional characterization of the cardiac ryanodine receptor pore-forming region. [PDF]
PLoS ONE, 2013 Ryanodine receptors are homotetrameric intracellular calcium release channels. The efficiency of these channels is underpinned by exceptional rates of cation translocation through the open channel and this is achieved at the expense of the high degree of
Joanne Euden +2 more
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Neuron, 2017 Summary Action potentials clustered into high-frequency bursts play distinct roles in neural computations. However, little is known about ionic currents that control the duration and probability of these bursts.
T. Irie, L. Trussell
semanticscholar +1 more source
Journal of Pharmacological Sciences, 2004 Adenosine enhanced intracellular Ca2+ concentrations in astrocytes via A2a adenosine receptors involving protein kinase A (PKA) activation. The Ca2+ rise is inhibited by brefeldin A, an inhibitor of vesicular transport; but not by neomycin and U73122 ...
Tomoyuki Nishizaki
doaj +1 more source
A bivalent remipede toxin promotes calcium release via ryanodine receptor activation
Nature Communications, 2023 Insect toxins with tandem repeats of neurotoxin domains have been found with enhanced receptor avidity. Here, the authors describe a bivalent toxin from remipede venom that targets ryanodine receptors, a rare target for animal venoms.
Michael J. Maxwell +13 more
doaj +1 more source
Journal of Neuroscience, 2017 Hyperalgesic priming, a model of pain chronification in the rat, is mediated by ryanodine receptor-dependent calcium release. Although ryanodine induces priming in both sexes, females are 5 orders of magnitude more sensitive, by an estrogen receptor α ...
E. Khomula +3 more
semanticscholar +1 more source
Brazilian Journal of Medical and Biological Research, 2000 Dopamine nigrostriatal neurons are important for motor control and may contain a particularly dense population of ryanodine receptors involved in the control of dopamine release.
F. Noël, M. Geurts, J.-M. Maloteaux
doaj +1 more source
Ryanodine receptors: physiological function and deregulation in Alzheimer disease
Molecular Neurodegeneration, 2014 Perturbed Endoplasmic Reticulum (ER) calcium (Ca2+) homeostasis emerges as a central player in Alzheimer disease (AD). Accordingly, different studies have reported alterations of the expression and the function of Ryanodine Receptors (RyR) in human AD ...
D. Del Prete, F. Checler, M. Chami
semanticscholar +1 more source
The Interplay of Rogue and Clustered Ryanodine Receptors Regulates Ca2+ Waves in Cardiac Myocytes
Frontiers in Physiology, 2018 Ca2+ waves in cardiac myocytes can lead to arrhythmias owing to delayed after-depolarisations. Based on Ca2+ regulation from the junctional sarcoplasmic reticulum (JSR), a mathematical model was developed to investigate the interplay of clustered and ...
Xudong Chen +6 more
doaj +1 more source