Results 21 to 30 of about 6,108 (207)
The effect of long-term oral dantrolene on the neuromuscular action of rocuronium: a case report [PDF]
Korean Journal of Anesthesiology, 2014 Oral dantrolene causes a dose-dependent depression of skeletal muscle contractility. A 52-year-old man treated with oral dantrolene for spasticity after spinal cord injury was scheduled to undergo irrigation and drainage of a thigh abscess under general ...
Jinwoo Jeon +4 more
doaj +1 more source
Hyperthermia and neurological catastrophe: An interesting case report
Journal of Family Medicine and Primary Care, 2022 Fever is a common symptom encountered in clinical practice. Hyperthermia, though infrequently encountered, can be genetical (malignant hyperthermia) or acquired when the body temperature rises beyond a certain set point that is controlled by the ...
Khyati Thapliyal +2 more
doaj +1 more source
Selective RyR2 inhibition reduces arrhythmia susceptibility in human cardiac slices. [PDF]
J PhysiolAbstract figure legend ent‐Vert selectively inhibits RyR2‐mediated sarcoplasmic reticulum (SR) Ca2+ leak and prevents triggered activity in human cardiac slices. A, in human ventricular slices exposed to β‐adrenergic stimulation with Iso and RyR2 sensitization with caffeine, RyR2 channels become hyperactive, leading to Ca2+ sarcoplasmic leak and ...
Madrid MK +8 more
europepmc +2 more sources
Spectrometric Analysis of Dantrolene Sodium
, 2023 Dantrolene sodium is a direct-acting skeletal muscle relaxant. Dantrolene sodium for injection is indicated, along with suitable supportive measures, for the management of sudden, severe hypermetabolism of skeletal muscle typical of malignant ...
Philip Almeter (11325969) +6 more
core +1 more source
A phase Ib/IIa clinical trial of dantrolene sodium in patients with Wolfram syndrome
JCI Insight, 2021 BACKGROUND Wolfram syndrome is a rare ER disorder characterized by insulin-dependent diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration.
Damien Abreu +16 more
doaj +1 more source
A case of malignant hyperthermia during anesthesia induction with sevoflurane -A case report- [PDF]
Korean Journal of Anesthesiology, 2010 We experienced a case of malignant hyperthermia (MH) in 6-year-old boy during anesthesia induction for strabismus surgery. It has been generally reported that sevoflurane can induce the delayed onset of MH in the absence of succinylcholine.
Yoon Sook Lee +6 more
doaj +1 more source
Dantrolene enhances the protective effect of hypothermia on cerebral cortex neurons
Neural Regeneration Research, 2015 Therapeutic hypothermia is the most promising non-pharmacological neuroprotective strategy against ischemic injury. However, shivering is the most common adverse reaction. Many studies have shown that dantrolene is neuroprotective in in vitro and in vivo
Sui-yi Xu +6 more
doaj +1 more source
Dantrolene Prevents the Lymphostasis Caused by Doxorubicin in the Rat Mesenteric Circulation
Frontiers in Pharmacology, 2021 Background and Purpose: Doxorubicin (DOX) is a risk factor for arm lymphedema in breast cancer patients. We reported that DOX opens ryanodine receptors (RYRs) to enact “calcium leak,” which disrupts the rhythmic contractions of lymph vessels (LVs) to ...
Serena Van +8 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2018 Duchenne muscular dystrophy (DMD) is caused by mutations in DMD, resulting in loss of dystrophin, which is essential to muscle health. DMD “exon skipping” uses anti-sense oligo-nucleotides (AONs) to force specific exon exclusion during mRNA processing to
Derek W. Wang +8 more
doaj +1 more source
PLoS ONE, 2015 Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a highly malignant inherited arrhythmogenic disorder. Type 1 CPVT (CPVT1) is caused by cardiac ryanodine receptor (RyR2) gene mutations resulting in abnormal calcium release from ...
Kirsi Penttinen +6 more
doaj +1 more source