Results 21 to 30 of about 1,955 (161)

Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models.

PLoS ONE, 2015
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a highly malignant inherited arrhythmogenic disorder. Type 1 CPVT (CPVT1) is caused by cardiac ryanodine receptor (RyR2) gene mutations resulting in abnormal calcium release from ...
Kirsi Penttinen, Heikki Swan, Sari Vanninen, Jere Paavola, Annukka M Lahtinen, Kimmo Kontula, Katriina Aalto-Setälä   +6 more
doaj   +1 more source

Early Recognition and Treatment of Malignant Hyperthermia in Pediatric Patient during Bronchoscopy

Case Reports in Anesthesiology, 2020
Malignant hyperthermia is a rare pharmacogenetic disorder triggered by depolarizing muscle relaxant and potent volatile anesthetic agents. An MH crisis is an emergency and life-threatening event requiring early recognition and prompt management ...
Warangkana Lapisatepun, Supawan Arkarattanakul   +1 more
doaj   +1 more source

Dantrolene use across surgical and medical care at Mayo Clinic from 2010 to 2024: Indications, frequency, and value for identifying malignant hyperthermia

Biomolecules & Biomedicine
Dantrolene is the definitive treatment for malignant hyperthermia (MH), a rare and life-threatening disorder. This retrospective study aimed to achieve two objectives: (1) to characterize the indications and frequency of dantrolene administration in ...
David Cho, Toby N. Weingarten, Juraj Sprung, Aurelia Zodl, Martin J. Ryll, Tracy E. Harrison   +5 more
doaj   +1 more source

Pharyngeal spasticity due to dantrolene

, 2014
What is known and objective: Dantrolene can be combined with baclofen to better treat spasticity, but may cause muscular weakness and dysphagia. We instead describe a pharyngeal spasm due to dantrolene.
F. Locatelli, S. Strazzer, M. Pozzi, P. Avantaggiato, S. Galbiati, M. Lanfranchi, L. Tufarulo, G. Rizzi, S. Radice, E. Clementi, V. Amorelli   +10 more
core   +1 more source

Effect of dantrolene on rat brain tryptophan hydroxylase [PDF]

, 1988
Recently, dantrolene has been applied to the treatment of neuroleptic malignant syndrome. In some treated patients, dramatic changes in the electroencephalogram and in the levels of monoamine metabolites in cerebrospinal fluid were observed. Nonetheless,
Shoshiro OKADA, Okada, Shoshiro
core   +1 more source

Dantrolene reduces CaMKIIδC-mediated atrial arrhythmias

, 2020
Aims In atrial fibrillation (AF), an increased diastolic Ca2+ leak from the sarcoplasmic reticulum (SR) mediated by calcium/calmodulin-dependent-protein-kinaseIIdC (CaMKII) can serve as a substrate for arrhythmia induction and persistence. Dantrolene has
Rupprecht, Leopold, Lebek, Simon, Neef, Stefan, Wagner, Stefan, Maier, Lars S., Stehle, Thea, Mustroph, Julian, Dybkova, Nataliya, Sossalla, Samuel, Pabel, Steffen, Keyser, Andreas, Maier, Lars S   +11 more
core   +1 more source

Malignant hyperthermia in a regional facility: A case study

Journal of Perioperative Nursing, 2020
Malignant hyperthermia (MH) is a rare hypermetabolic state that may be triggered by both anaesthesia and non-anaesthesia triggers. The main anaesthesia triggers for MH are the depolarising muscle relaxant suxamethonium and volatile anaesthetic gases. MH
Catherine Kleidon
doaj   +1 more source

Síndrome neuroléptica maligna: relato de caso com recorrência associada ao uso de olanzapina [PDF]

Arquivos de Neuro-Psiquiatria, 1998
A síndrome neuroléptica maligna (SNM) consiste em reação idiossincrática a neurolépticos, provavelmente relacionada a bloqueio dos receptores dopaminérgicos nos gânglios da base, sendo por isso também conhecida como síndrome da deficiência aguda de ...
RICARDO A. HANEL, MARCOS C. SANDMANN, MARTINA KRANICH, PAULO R. M. DE BITTENCOURT   +3 more
doaj   +1 more source

Effect of dantrolene on calcium transients.

, 2014
A) Depolarization with 60 mM KCl and 20 mM caffeine in normal buffer, followed by exposure to sequential exposures to caffeine in the presence of 10 µM dantrolene. B) The amplitude of the caffeine transient in the absence or presence of dantrolene.
Pilar Martin-Duque (620116), Georges Vassaux (329006), Marta Fernandez-Fuente (255181), Richard J. Piercy (102272), Cesare M. Terracciano (620115), Susan C. Brown (358374)   +5 more
core   +1 more source

Targeting RyR Activity Boosts Antisense Exon 44 and 45 Skipping in Human DMD Skeletal or Cardiac Muscle Culture Models

Molecular Therapy: Nucleic Acids, 2019
Systemic delivery of antisense oligonucleotides (AO) for DMD exon skipping has proven effective for reframing DMD mRNA, rescuing dystrophin expression, and slowing disease progression in animal models.
Florian Barthélémy, Richard T. Wang, Christopher Hsu, Emilie D. Douine, Eugene E. Marcantonio, Stanley F. Nelson, M. Carrie Miceli   +6 more
doaj   +1 more source