Results 11 to 20 of about 10,940 (260)
Frontiers in Medicine, 2022 Malignant hyperthermia (MH) is a rare life-threatening response that is triggered by exposure to specific anesthetics commonly used during surgical interventions. Dantrolene is a well-known drug used as the first-line therapy for MH.
Xiaoxiao Li +15 more
doaj +1 more source
BMC Anesthesiology, 2022 Background Intravenous dantrolene is often prescribed for hypermetabolic syndromes other than the approved indication of malignant hyperthermia (MH). To clarify the extent of and indications for dantrolene use in conditions other than MH, we sought to ...
Stanley N. Caroff +7 more
doaj +1 more source
Functional recovery after dantrolene-supplementation of cold stored hearts using an ex vivo isolated working rat heart model. [PDF]
PLoS ONE, 2018 The ryanodine receptor antagonist dantrolene inhibits calcium release from the sarcoplasmic reticulum and reduces cardiac ischaemia-reperfusion injury (IRI) in global warm ischaemia models however the cardioprotective potential of dantrolene under ...
Jeanette E Villanueva +8 more
doaj +1 more source
Dantrolene prevents hepatic steatosis by reducing cytoplasmic Ca2+ level and ER stress
Biochemistry and Biophysics Reports, 2020 Introduction: Our previous studies demonstrated that dantrolene, a ryanodine receptor stabilizer, prevents endoplasmic reticulum (ER) stress in the heart.
Masaki Tamitani +12 more
doaj +1 more source
Frontiers in Physiology, 2021 Ryanodine receptors (RyRs), the intracellular Ca2+ release channels, are expressed in T lymphocytes and other types of immune cells. Modulation of RyRs has been shown to affect T cell functions in vitro and immune responses in vivo.
Natalia C. Osipchuk +3 more
doaj +1 more source
RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays. [PDF]
, 2020 Elevated cytoplasmic [Ca2+] is characteristic in severe skeletal and cardiac myopathies, diabetes, and neurodegeneration, and partly results from increased Ca2+ leak from sarcoplasmic reticulum stores via dysregulated ryanodine receptor (RyR) channels ...
Bers, Donald M +6 more
core +2 more sources
Hyperthermia and neurological catastrophe: An interesting case report
Journal of Family Medicine and Primary Care, 2022 Fever is a common symptom encountered in clinical practice. Hyperthermia, though infrequently encountered, can be genetical (malignant hyperthermia) or acquired when the body temperature rises beyond a certain set point that is controlled by the ...
Khyati Thapliyal +2 more
doaj +1 more source
Scientific Reports, 2021 Diabetics have a higher risk of developing cerebral vasospasms (CVSP) after subarachnoid hemorrhagic stroke than non-diabetics. Serotonin (5-HT) is one of the key vasoconstrictors released in the hemorrhagic blood and an important contributor to the ...
Marie Román +3 more
doaj +1 more source
Basal ryanodine receptor activity suppresses autophagic flux [PDF]
, 2017 The inositol 1,4,5-trisphosphate receptors (IP3Rs) and intracellular Ca2+ signaling are critically involved in regulating different steps of autophagy, a lysosomal degradation pathway.
Bannai, Hiroko +9 more
core +2 more sources
Heart Rhythm O2, 2020 Background: Cardiac ryanodine receptor 2 (RyR2) dysfunction and elevated diastolic Ca2+ leak have been linked to arrhythmogenesis not only in inherited arrhythmia syndromes but also in acquired forms of heart disease including heart failure (HF) and ...
Colleen Nofi, DO +7 more
doaj +1 more source