Results 11 to 20 of about 6,108 (207)
Intranasal administration of dantrolene increased brain concentration and duration.
PLoS ONE, 2020 Dantrolene has been demonstrated to be neuroprotective for multiple neurodegenerative diseases. However, dantrolene's limited penetration into the CNS hampers its effectiveness as a neuroprotective agent.
Jintao Wang +7 more
doaj +2 more sources
Dantrolene is neuroprotective in Huntington's disease transgenic mouse model
Molecular Neurodegeneration, 2011 Background Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine expansion in the Huntingtin protein which results in the selective degeneration of striatal medium spiny neurons (MSNs).
Chen Xi +5 more
doaj +2 more sources
Acta Medica Iranica, 2016 Ryanodine receptor abnormalities has implicated in the generation and maintenance of seizure. Dantrolene, a selective ryanodine receptor antagonist, may be a potential drug for the prevention of seizure.
Mojtaba Keshavarz +2 more
doaj +1 more source
The Possible Protective Role of Verapamil and Dantrolene in Experimentally Induced Early Acute Pancreatitis in Male Albino Rat [PDF]
The Egyptian Journal of Histology, 2023 Introduction: The aim of the present work was to elucidate the possible protective role of Verapamil (VPM) and Dantrolene (Da) in controlling experimentally induced early acute pancreatitis (AP) in male albino rats.Materials and Methods: Thirty- two ...
Ahmed Taha +4 more
doaj +1 more source
Frontiers in Physiology, 2021 Ryanodine receptors (RyRs), the intracellular Ca2+ release channels, are expressed in T lymphocytes and other types of immune cells. Modulation of RyRs has been shown to affect T cell functions in vitro and immune responses in vivo.
Natalia C. Osipchuk +3 more
doaj +1 more source
Monosodium glutamate-mediated Ca<sup>2+</sup>-dependent intestinal epithelial ion transports in health and IBS-D in male mice. [PDF]
Physiol RepAbstract Despite the ubiquitous use of monosodium glutamate (MSG) as a food additive, its specific effects on intestinal health and disease remain largely unclear. Here we found mucosal application of MSG induced an upward intestinal short‐circuit current (Isc) in the murine ileum, which was significantly reduced by extracellular Cl−, Na+, and Ca2 ...
Wang Y, Chu F, Gong Y, Guo R, Dong H.
europepmc +2 more sources
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3 [PDF]
, 2008 Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is an autosomal-dominant neurodegenerative disorder caused by a polyglutamine expansion in ataxin-3 (SCA3, MJD1) protein.
X. Chen +15 more
core +1 more source
Dantrolene: In doxorubicin toxicity [PDF]
, 2007 Doxorubicin (DOX) is a widely used anthracycline in the treatment of hematological and solid tumors. However, there are serious toxic effects on cardiovascular and hematopoietic system, which limits the use of the drug.
Taysi, Seyithan +2 more
core +3 more sources
Scientific Reports, 2021 Diabetics have a higher risk of developing cerebral vasospasms (CVSP) after subarachnoid hemorrhagic stroke than non-diabetics. Serotonin (5-HT) is one of the key vasoconstrictors released in the hemorrhagic blood and an important contributor to the ...
Marie Román +3 more
doaj +1 more source
Heart Rhythm O2, 2020 Background: Cardiac ryanodine receptor 2 (RyR2) dysfunction and elevated diastolic Ca2+ leak have been linked to arrhythmogenesis not only in inherited arrhythmia syndromes but also in acquired forms of heart disease including heart failure (HF) and ...
Colleen Nofi, DO +7 more
doaj +1 more source