Results 11 to 20 of about 1,955 (161)
Acta Medica Iranica, 2016 Ryanodine receptor abnormalities has implicated in the generation and maintenance of seizure. Dantrolene, a selective ryanodine receptor antagonist, may be a potential drug for the prevention of seizure.
Mojtaba Keshavarz +2 more
doaj +1 more source
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3 [PDF]
, 2008 Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is an autosomal-dominant neurodegenerative disorder caused by a polyglutamine expansion in ataxin-3 (SCA3, MJD1) protein.
X. Chen +15 more
core +1 more source
Dantrolene Prevents the Lymphostasis Caused by Doxorubicin in the Rat Mesenteric Circulation
Frontiers in Pharmacology, 2021 Background and Purpose: Doxorubicin (DOX) is a risk factor for arm lymphedema in breast cancer patients. We reported that DOX opens ryanodine receptors (RYRs) to enact “calcium leak,” which disrupts the rhythmic contractions of lymph vessels (LVs) to ...
Serena Van +8 more
doaj +1 more source
A phase Ib/IIa clinical trial of dantrolene sodium in patients with Wolfram syndrome
JCI Insight, 2021 BACKGROUND Wolfram syndrome is a rare ER disorder characterized by insulin-dependent diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration.
Damien Abreu +16 more
doaj +1 more source
Hyperthermia and neurological catastrophe: An interesting case report
Journal of Family Medicine and Primary Care, 2022 Fever is a common symptom encountered in clinical practice. Hyperthermia, though infrequently encountered, can be genetical (malignant hyperthermia) or acquired when the body temperature rises beyond a certain set point that is controlled by the ...
Khyati Thapliyal +2 more
doaj +1 more source
Spectrometric Analysis of Dantrolene Sodium
, 2023 Dantrolene sodium is a direct-acting skeletal muscle relaxant. Dantrolene sodium for injection is indicated, along with suitable supportive measures, for the management of sudden, severe hypermetabolism of skeletal muscle typical of malignant ...
Philip Almeter (11325969) +6 more
core +1 more source
Dantrolene enhances the protective effect of hypothermia on cerebral cortex neurons
Neural Regeneration Research, 2015 Therapeutic hypothermia is the most promising non-pharmacological neuroprotective strategy against ischemic injury. However, shivering is the most common adverse reaction. Many studies have shown that dantrolene is neuroprotective in in vitro and in vivo
Sui-yi Xu +6 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2018 Duchenne muscular dystrophy (DMD) is caused by mutations in DMD, resulting in loss of dystrophin, which is essential to muscle health. DMD “exon skipping” uses anti-sense oligo-nucleotides (AONs) to force specific exon exclusion during mRNA processing to
Derek W. Wang +8 more
doaj +1 more source
A case of malignant hyperthermia during anesthesia induction with sevoflurane -A case report- [PDF]
Korean Journal of Anesthesiology, 2010 We experienced a case of malignant hyperthermia (MH) in 6-year-old boy during anesthesia induction for strabismus surgery. It has been generally reported that sevoflurane can induce the delayed onset of MH in the absence of succinylcholine.
Yoon Sook Lee +6 more
doaj +1 more source
Dantrolene: In doxorubicin toxicity [PDF]
, 2007 Doxorubicin (DOX) is a widely used anthracycline in the treatment of hematological and solid tumors. However, there are serious toxic effects on cardiovascular and hematopoietic system, which limits the use of the drug.
Taysi, Seyithan +2 more
core +2 more sources