Therapeutic targeting of chromatin alterations in leukemia and solid tumors
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
Malignant Mesothelioma of the Pericardium: A Report of Two Different Presentations
Malignant mesothelioma of the pericardium is a rare and fatal condition that clinicians should be aware of due to its variability of clinical manifestation. The diagnosis may be delayed as a result of delayed treatment.
Pattarapong Makarawate +7 more
doaj +1 more source
Surgery and Survival of Patients with Diagnosis of Malignant Pleural Mesothelioma: In Response [PDF]
Andrea Billè, Luca Porcu
openalex +1 more source
European Code Against Cancer, 5th edition – occupational exposures and cancer
The 5th edition of the European Code Against Cancer (ECAC5) updates cancer prevention recommendations on occupational exposures, listed at position 9. Individuals are advised to inform themselves about cancer‐causing factors at work and call on their employer to protect them against these factors.
Sylvia H. J. Jochems +17 more
wiley +1 more source
Targeting the Dynamics Between TAMs and CAR‐T Cells in Solid Tumor Therapies
This review highlights the critical role of tumor‐associated macrophages (TAMs) in affecting CAR‐T cell therapy effectiveness in solid tumors. TAMs contribute to immune suppression through cytokine secretion, immune checkpoint activation, and metabolic reprogramming, leading to CAR‐T cell exhaustion and reduced efficacy. The article explores strategies
Xiang Zhang +7 more
wiley +1 more source
O-56 Incidence of malignant mesothelioma in Lombardy, Italy: accuracy of predictive models 2013–2020 [PDF]
Dario Consonni +7 more
openalex +1 more source
Krüppel‐Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment
Krüppel‐like factor 4 (KLF4) exhibits a dual, context‐dependent role, acting as both a tumor suppressor and an oncogene. It remodels the tumor microenvironment by modulating cancer, stromal, and immune cells, representing a promising yet complex therapeutic target for cancer treatment.
Min Tang +5 more
wiley +1 more source
Downregulation of TNFAIP3 Associated With Poor Prognosis and Immune Response in Breast Cancer
ABSTRACT Background Breast cancer (BRCA) progression is closely linked to dysregulated inflammatory processes within the tumor microenvironment (TME). TNFAIP3, a key regulator of TNF‐α signaling, plays a dual role in cancer biology, but its precise function in BRCA pathogenesis and immune modulation remains unclear.
Yeqin Wu, Zhaoyang Qin, Gangping Wang
wiley +1 more source
The Evolution of Asbestos Bankruptcy Trust Distribution Plans [PDF]
The evolution of asbestos litigation from the early 1970s to the present has become the source of much analysis. One commentator divides this history into several phases: the heroic phase, bureaucratic floundering, adaptation and maturity, search for ...
McGovern, Francis
core +1 more source
MA12.03 The Impact of Malignant Pleural Mesothelioma Histology on the Use of Surgery and Survival in a Population-Based Analysis [PDF]
Chi‐Fu Jeffrey Yang +5 more
openalex +1 more source

