Results 111 to 120 of about 48,810 (253)

Genomics and Epigenetics of Malignant Mesothelioma

, 2018
Malignant mesothelioma is an aggressive and lethal asbestos-related disease. Diagnosis of malignant mesothelioma is particularly challenging and is further complicated by the lack of disease subtype-specific markers.
Dustin D. Pearson, Wan L. Lam, Victor D. Martinez, Adam P. Sage, Brenda C. Minatel, Erin A. Marshall, Graham Dellaire, Gavin M. MacAulay, Aaron A. Goodarzi, Roland Hubaux, Michelle E. Pewarchuk   +10 more
core   +1 more source

Urokinase Plasminogen Activator Receptor‐Associated Protein (uPARAP) as a Potential Next Generation Molecular Target for Treatment of Gastrointestinal Stromal Tumors (GIST)

International Journal of Cancer, Volume 159, Issue 3, Page 797-808, 1 August 2026.
A key component of the collagen internalization and lysosomal degradation cellular machinery, uPARAP may contribute to cancer progression. Here, the authors explored the expression of uPARAP in gastrointestinal stromal tumors using well‐annotated clinical patient samples and specimens from cell line‐ and patient‐derived xenografts.
Chao‐Chi Wang, Flavia Paternostro, Agnieszka Wozniak, Lore De Cock, Luna De Sutter, Kimberly Verbeeck, Ulla Vanleeuw, Daniël Gorgels, Che‐Jui Lee, Raf Sciot, Patrick Schöffski   +10 more
wiley   +1 more source

Peritoneal malignant mesothelioma: case report [PDF]

, 2007
Our study reports peritoneal diffuse malignant mesothelioma (DMM) in a 43 years old male patient, with no exposure to the asbestos in his medical history; the partner of patient was also not exposed to asbestos. The exposure to X-rays was also excluded.
Catania, Gaetano, Accurso, N., Proietti, Lidia, Calì, Sergio, Di Stefano, Carla, Tenaglia, Luigi, Trovato, Santi   +6 more
core  

Putative cancer stem cells in malignant pleural mesothelioma show resistance to cisplatin and pemetrexed

, 2010
Malignant pleural mesothelioma (MPM) is a lethal cancer of the mesothelium with high chemotherapeutic resistance via unknown mechanisms. A prevailing hypothesis states that cancer stem cells (CSCs) persist in tumors causing relapse after chemotherapy ...
Carboni, Giovanni L, Karoubi, Golnaz, Schmid, Ralph A, Cortes-Dericks, Lourdes   +3 more
core   +1 more source

Malignant craniopharyngiomas: Institutional experience and literature review

Brain Pathology, Volume 36, Issue 4, July 2026.
We report the second case of malignant craniopharyngioma with BAP1 and TP53 mutations. A literature review identified 44 cases of malignant craniopharyngiomas with a median overall survival of 6 months. Eighteen (41%) occurred in patients without any history of radiation, suggesting that mechanisms other than radiation have contributed to their ...
Thomas J. Auen, Isabella W. Zhang, Weiwei Zhang, Jordan M. Burr, Matthew L. Carda, James L. Wisecarver, Nicole Shonka, Jesse L. Cox, Sahara J. Cathcart, Allison Cushman‐Vokoun, Jie Chen   +10 more
wiley   +1 more source

Pegargiminase Suppresses the Fanconi Anemia Pathway and Promotes Melphalan‐Induced DNA Double‐Strand Breaks in Uveal Melanoma

Pigment Cell &Melanoma Research, Volume 39, Issue 4, July 2026.
ADI‐PEG20 enhances melphalan‐induced DNA DSBs in UM cells. We describe potentiation of DNA DSBs in UM cell lines upon treatment with ADI‐PEG20 and melphalan (92.1 cells with STRIDE by intoDNA). ADI‐PEG20 suppresses multiple members of the FA pathway—a known resistance mechanism for melphalan—providing a rationale for exploring this drug combination in ...
Iuliia Pavlyk, George Field, Matthew Young, Josephine Carpentier, Emilia A. Szlosarek, Michaela R. O'Keeffe‐Brown, Timothy Crook, Nelofer Syed, John S. Bomalaski, Pui Ying Chan, Peter W. Szlosarek   +10 more
wiley   +1 more source

Malignant Mesothelioma

Siriraj Medical Journal, 2002
A 27 year old Thai male presented with progressive abdominal distension without leg edema, low grade fever and 10 Kgs weight loss over 2 months.
Phunchai Charuscharoenwitthaya, Cherdsak Iramaneerat, Ranista Suchato, Soranat Muangsomboon   +3 more
doaj  

Malignant Mesothelioma of the Pericardium: A Report of Two Different Presentations

Case Reports in Oncological Medicine, 2013
Malignant mesothelioma of the pericardium is a rare and fatal condition that clinicians should be aware of due to its variability of clinical manifestation. The diagnosis may be delayed as a result of delayed treatment.
Pattarapong Makarawate, Narumol Chaosuwannakit, Jarin Chindaprasirt, Piti Ungarreevittaya, Surachat Chaiwiriyakul, Kosin Wirasorn, Chusak Kuptarnond, Kittisak Sawanyawisuth   +7 more
doaj   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, Volume 15, Issue 23, 19 June 2026.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Integrating Oncolytic Virus Engineering and Delivery Strategies for Enhanced Cancer Virotherapy

Aggregate, Volume 7, Issue 6, June 2026.
Integrated engineering strategies combining oncolytic virus (OV) design with advanced delivery platforms overcome biological barriers and enhance cancer virotherapy. Genetic engineering improves viral potency and selectivity, while local and systemic delivery systems promote viral protection, tumor targeting, penetration, and tumor microenvironment ...
Jiliang Zhao, Dong Wang, Lei Wang, Hongkai Zhang, Yue Sun, Dan Ding   +5 more
wiley   +1 more source