Results 101 to 110 of about 1,884,278 (256)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Second Malignant Neoplasms Following Multiple Myeloma: A Cohort Study On 744 Patients Treated 1997-2011

, 2013
Introduction Second malignant neoplasms after first-line therapy and maintenance-therapy have been reported in clinical studies; however, no risk factors have been established.
Ihorst, Gabriele, Landgren, Ola, Engelhardt, Monika, Kleber, Martina, Koch, Bernd, Landgren, Carl, Höck, Kerstin, Waesch, Ralph   +7 more
core   +1 more source

Histology and fine-needle aspiration cytology of malignant thyroid neoplasms.

, 2000
Histology and fine-needle aspiration cytology of malignant thyroid ...
V.A., Fadda G, LiVolsi
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Risk Factors for the Occurrence of Cutaneous Neoplasms in Dogs: A Retrospective Study by Cytology Reports, 2019–2021

Animals
Studies worldwide report cutaneous neoplasms in dogs; however, data in the arid regions of Mexico remain scarce. Here we report the main malignant cutaneous neoplasms diagnosed by fine needle aspiration cytology (FNAC), and describe the associations with
Issa Carolina García-Reynoso, Cesar Augusto Flores-Dueñas, Nohemí Castro-del Campo, Mariana Jácome-Ibarra, José Carlomán Herrera-Ramírez, Sergio Daniel Gómez-Gómez, Miguel Ángel Rodríguez-Gaxiola, Soila Maribel Gaxiola-Camacho   +7 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Advanced Statistical Analysis of The Development Tendency of Mortality from Malignant Neoplasms and the Lifestyle of Patients Sick from Malignant Neoplasms in R. N. Macedonia

The primary goals of this research are: to determine the development tendency of mortality from malignant neoplasms in R. N. Macedonia and to determine the impact of diet and lifestyle on the appearance and development of malignant neoplasms.
Idrizi, Jezair, Luma, Reyhana, Tanevski, Vlatko, Alia, Durim, Ferati, Ismail   +4 more
core   +1 more source

Risk factors for malignant progression of intraductal papillary mucinous neoplasms

, 2015
Intraductal papillary mucinous neoplasms of the pancreas are increasingly diagnosed.
Raimondo, Massimo, Woodward, Timothy A, Moris, Maria, De Angelis, Claudio, Wallace, Michael B., FUSAROLI, PIETRO, Petrone, Maria C, Arcidiacono, Paolo G, Manfrè, Selene, Skinner, Verna   +9 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Proton magnetic resonance and human thyroid neoplasia I: Discrimination between benign and malignant neoplasms

, 1994
Purpose\ud \ud Thyroid nodules are very common, yet the vast majority are biologically benign. The extreme difficulty facing the clinician selecting potentially malignant thyroid nodules for surgery was the subject of a recent editorial by Ernest L ...
Dowd, Susan, Lean, CL, Delbridge, Leigh, Mountford, CE, Mountford, Carolyn E., Russell, P, Russell, Peter, Dowd, S, May, George L., May, GL, Lean, Cynthia L., Delbridge, L   +11 more
core   +1 more source