Results 121 to 130 of about 72,644 (316)

Factors influencing malignant mesothelioma survival: a retrospective review of the National Mesothelioma Virtual Bank cohort [version 3; peer review: 2 approved, 1 approved with reservations]

open access: yesF1000Research, 2019
Background: Malignant mesothelioma (MM) is a rare but deadly malignancy with about 3,000 new cases being diagnosed each year in the US.  Very few studies have been performed to analyze factors associated with mesothelioma survival, especially for ...
Waqas Amin   +10 more
doaj   +1 more source

Novel TEAD1 Inhibitor VT103 Enhances Dabrafenib Efficacy in BRAF V600E Mutated Lung Adenocarcinoma via Survivin Downregulation

open access: yesCancer Science, Volume 116, Issue 7, Page 1883-1896, July 2025.
We established a novel patient‐derived BRAF V600E‐mutated lung adenocarcinoma cell line and demonstrated that combining a novel TEAD1 inhibitor (VT103) with dabrafenib enhances therapeutic efficacy through survivin downregulation. Our tissue microarray analysis revealed a strong correlation between YAP1, TEAD1, and survivin expression in lung ...
Kazutaka Hosoya   +19 more
wiley   +1 more source

Dose de-escalation of intrapleural tissue plasminogen activator therapy for pleural infection. The alteplase dose assessment for Pleural infection Therapy project [PDF]

open access: yes, 2017
Rationale: Intrapleural therapy with a combination of tissue plasminogen activator (tPA) 10 mg and DNase 5 mg administered twice daily has been shown in randomized and open-label studies to successfully manage over 90% of patients with pleural infection ...
Bintcliffe, Oliver   +10 more
core   +1 more source

Factors influencing malignant mesothelioma survival: a retrospective review of the National Mesothelioma Virtual Bank cohort [version 1; referees: 1 approved, 2 approved with reservations]

open access: yesF1000Research, 2018
Background: Malignant mesothelioma (MM) is a rare but deadly malignancy with about 3,000 new cases being diagnosed each year in the US.  Very few studies have been performed to analyze factors associated with mesothelioma survival, especially for ...
Waqas Amin   +4 more
doaj   +1 more source

Comprehensive immunoproteogenomic analyses of malignant pleural mesothelioma

open access: yesJCI Insight, 2018
We generated a comprehensive atlas of the immunologic cellular networks within human malignant pleural mesothelioma (MPM) using mass cytometry. Data-driven analyses of these high-resolution single-cell data identified 2 distinct immunologic subtypes of ...
Hyun-Sung Lee   +13 more
semanticscholar   +1 more source

Epidemiological patterns of asbestos exposure and spatial clusters of incident cases of malignant mesothelioma from the Italian national registry. [PDF]

open access: yes, 2015
BACKGROUND: Previous ecological spatial studies of malignant mesothelioma cases, mostly based on mortality data, lack reliable data on individual exposure to asbestos, thus failing to assess the contribution of different occupational and environmental ...
Angelillo, Italo   +30 more
core   +2 more sources

ADAM10 mediates malignant pleural mesothelioma invasiveness

open access: yesOncogene, 2019
Malignant pleural mesothelioma (MPM) is an aggressive cancer with limited therapeutic options and treatment efficiency. Even if the latency period between asbestos exposure, the main risk factor, and mesothelioma development is very long, the local ...
C. Sépult   +9 more
semanticscholar   +1 more source

Solitary fibrous tumour of the nose and nasopharynx [PDF]

open access: yes, 1993
A case of solitary fibrous tumour of the nasal cavity is reported. These tumours, rare in the nose, are believed to be similar to fibrous mesotheliomas of the pleural cavity.
DeGaetano, James   +2 more
core  

Inducers of epithelial mesenchymal transition and cancer stem cells in malignant pleural effusions [PDF]

open access: yes, 2016
The Epithelial to Mesenchymal Transition (EMT) plays a role not only in tumor metastasis but also in tumor recurrence. This process is believed to be tightly linked to the presence of Cancer Stem Cells (CSCs) however, it is still not clear which ...
Cherubini, Emanuela   +5 more
core   +1 more source

Malignant pleural mesothelioma without asbestos exposure with distant metastasis in a peripheral lymph node: A case report

open access: yesLung India, 2008
Malignant mesothelioma is an uncommon pleural neoplasm and usually associated with inhalation exposure to asbestos. About 20% of the patients have no demon-strable exposure to asbestos. It rarely metastasizes in peripheral lymph nodes.
Kant Surya, Verma Sanjay, Sanjay
doaj  

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