Results 151 to 160 of about 5,165,410 (355)

Identification of anoikis-related subtypes and a risk score prognosis model, the association with TME landscapes and therapeutic responses in hepatocellular carcinoma

Frontiers in Immunology
IntroductionAnoikis is a distinct form of programmed cell death, differing from classical apoptosis, and its role in malignant tumor progression, particularly in hepatocellular carcinoma (HCC), remains insufficiently understood.
Xiangyu Zhai, Xiangyu Zhai, Kecheng Li, Hailing Ding, Yanmei Wu, Xinlu Zhang, Hao Zhang, Huaxin Zhou, Huaxin Zhou, Chongzhong Liu, Zili Zhang, Bin Jin, Bin Jin   +12 more
doaj   +1 more source

Endoscopic ultrasound in the staging of gastrointestinal luminal malignancies [PDF]

, 2013
Endoscopic ultrasound (EUS) is an important tool in the staging of gastrointestinal cancers. This review highlights the use of EUS in the staging of gastrointestinal luminal malignancies and compares the performance of EUS with other imaging modalities ...
Azzopardi, Neville
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Stemness- and hypoxia-based prognostic stratification index reveals G6PD as a regulator of hypoxia-driven stemness in hepatocellular carcinoma

Frontiers in Immunology
BackgroundThe positive feedback loop between cancer stemness and the hypoxic microenvironment is a critical driver of hepatocellular carcinoma (HCC) progression.
Mingwei Gao, Mingwei Gao, Mingwei Gao, Yuechuan Liu, Yuechuan Liu, Yuechuan Liu, Jianhui Wu, Jianhui Wu, Peiru Zhang, Peiru Zhang, Jin Liu, Jin Liu, Kun Guo, Kun Guo, Binwen Sun, Binwen Sun, Sunbin Ling, Sunbin Ling, Liming Wang, Liming Wang, Liming Wang   +20 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

PD-L1-targeted photodynamic therapy orchestrates checkpoint blockade and immunogenic cell death for synergistic cancer immunotherapy

Redox Biology
Inhibiting the PD1/PD-L1 interaction is crucial for developing novel cancer immunotherapies, particularly to reduce systemic toxicity and enhance patient response rates.
Sijin Liu, Zhaoting Yang, Biao Wang, Shuyu Huan, Zixi Li, Xunbin Wei, Guoquan Liu   +6 more
doaj   +1 more source

Metaplastic Carcinoma of the Left Breast with Extensive Chondroid Differentiation [PDF]

, 2011
Metaplastic breast carcinoma is very rare neoplasm which contains mixture of carcinomatous (epithelial) and sarcomatous (mesenchymal) elements in variable proportion. Metaplastic carcinoma with chondroid differentiation is even rarer.
Bohra, Ashish, Jagtap, Sunil V, Jain, Gaurav, Kanetkar, Sujata R, Nikumbh, Dhiraj B   +4 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

TRIM25‐Mediated INSIG1 Ubiquitination Promotes MASH Progression Through Reprogramming Lipid Metabolism

Advanced Science
The global incidence of Metabolic dysfunction‐associated steatohepatitis (MASH) is increasing, highlighting the urgent need for new treatment strategies.
Hao Zhang, Xiangxu Kong, Wei Wang, Huaxin Zhou, Haoran Qu, Zhengyao Guan, Honglei Wu, Xiangyu Zhai, Bin Jin   +8 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source