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Cytotoxic and Antitumor Constituents in Pericarps ofMallotus japonicus
Planta Medica, 1990A variety of phloroglucinol derivatives isolated from the pericarps of Mallotus japonicus were assessed for growth inhibiting activity against human larynx (HEp-2) and lung (PC-13) carcinoma cells as well as mouse B16 melanoma, leukemia P388, and L5178Y cells. Most of these derivatives were proved to be significantly cytotoxic in culture.
M, Arisawa +3 more
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Studies on Cytotoxic Constituents in Pericarps of Mallotus japonicus, Part II
Journal of Natural Products, 1985Two new phloroglucinol derivatives, mallotolerin (8) and mallotochromanol (9), were isolated from the cytotoxic fraction of the pericarps of Mallotus japonicus. The new derivatives were identified as 3-(3-methyl-2-hydroxybut-3-enyl)-5-(3-acetyl-2,4-dihydroxy-5-me thy l-6- methoxybenxyl)-phlorbutyrophenone (8) and 8-acetyl-5,7-dihydroxy-6-(3-acetyl-2,4 ...
M, Arisawa +6 more
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Phloroglucinol derivatives from fruits of Mallotus japonicus
Phytochemistry, 1983Abstract Two new rottlerin-like phloroglucinol derivatives were isolated from the fruits of Mallotus japonicus and identified by chemical and spectral data as 3-(3, 3-dimethylallyl)-5-(3-acetyl-2, 4-dihydroxy-5-methyl-6-methoxybenzyl)-phloracetophenone and 3-(3-methyl-2-hydroxybut-3-enyl)-5-(3-acetyl-2, 4-dihydroxy-5-methyl-6-methoxybenzyl ...
Nobuharu Shigematsu +2 more
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Phenol glucoside gallates from Mallotus japonicus
Phytochemistry, 1989Abstract Five phenol glucoside gallates were isolated from Mallotus japonicus , and their structures characterized by chemical and spectroscopic means as 4-hydroxy-2-methoxyphenol 1- O -β- d -(6′- O -galloyl)glucoside, 4-hydroxy-3-methoxyphenol 1- O -β- d -(2′,6′-di- O -galloyl)glucoside, 4-hydroxy-3-methoxyphenol 1- O -β- d -2′,3′,6′-tri- O ...
Reiko Saijo +2 more
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Further phloroglucinol derivatives in the fruits of Mallotus japonicus
Phytochemistry, 1985Abstract Two new rottlerin-like phloroglucinol derivatives were detected from the fruits of Mallotus japonicus and identified as 3-(3,3-dimethylallyl)-5-(3-acetyl-2,4-dihydroxy-5-methyl-6-methoxybenzyl)-phlorobutyrophenone and -phloroisobutyrophenone by spectral studies.
Isao Kouno +3 more
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Structure and biosynthesis of malloprenols from Mallotus japonicus
Phytochemistry, 1980Abstract The mallo prenol isolated from the leaves of Mallotus japonicus was elucidated to be a mixture of (2Z,6Z, 10Z, 14Z, 18Z, 22Z, 26E, 30E, 34E)-3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaen-1-ol and its C45- and C55-homologues and not the previously reported structure.
Takayuki Suga +2 more
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Glucosylation of salicylic acid by cell suspension cultures of Mallotus japonicus
Plant Cell Reports, 1990Salicylic acid was converted into its O-glucoside when administered to cell suspension cultures of Mallotus japonicus. The efficiency of the glucosylation was highest in the cells grown in Linsmaier-Skoog medium containing 1 μM 2,4-dichlorophenoxy-acetic acid at any scale of culture (7 ml - 3 1).
Y, Umetani +4 more
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A review of the biological activity and chemistry of Mallotus japonicus (Euphorbiaceae)
Phytomedicine, 1994Biological and pharmacological activities of Mallotus japonicus (Euphorbiaceae) are reviewed. Chemical constituents, biological and pharmacological activities of tannins and related compounds, cardenolides, cytotoxicity, antitumor and antitumor-promoting effects, antiviral activity, and inhibition of HIV-RT activity of this plant are described.
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ent-Labdane Diterpenes from the Stems of Mallotus japonicus
Journal of Natural Products, 2013Eight new ent-labdane diterpenoids, mallonicusins A-H (1-8), were isolated from the stems of Mallotus japonicus. Their structures, including the absolute configurations, were determined by extensive analyses of spectroscopic data and the ECD spectra of the Pr(FOD)₃ complex of substrates in CCl₄. The absolute configuration of compound 1 was confirmed by
Li, De-Zheng +6 more
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Oncology, 2009
Mallotojaponm, a major constituent of the pericarps of Mallotus japonicus (Euphorbiaceae), inhibited the action of tumor promoter in vitro and in vivo; it inhibited tumor promoter-enhanced phospholipid metabolism in cultured cells, and also suppressed the promoting effect of 12-O-tetradecanoylphorbol-13-acetate on skin tumor formation in mice initiated
Y, Satomi +3 more
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Mallotojaponm, a major constituent of the pericarps of Mallotus japonicus (Euphorbiaceae), inhibited the action of tumor promoter in vitro and in vivo; it inhibited tumor promoter-enhanced phospholipid metabolism in cultured cells, and also suppressed the promoting effect of 12-O-tetradecanoylphorbol-13-acetate on skin tumor formation in mice initiated
Y, Satomi +3 more
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