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Malonic aciduria

Brain and Development, 1994
Three infants with malonic aciduria are reported, one of whom could be studied in detail. All children had severe and progressive encephalopathy with intermittent ketoacidosis and hypoglycemia. One infant died of cardiomyopathy. Biochemical studies revealed that one patient had neither malonyl-CoA decarboxylase nor glutaryl-CoA dehydrogenase ...
P T, Ozand   +3 more
openaire   +2 more sources

Enantioselective Michael Addition of Malonates to Enones

Current organic chemistry, 2020
Many catalysts were tested in asymmetric Michael additions in order to synthesize enantioenriched products. One of the most common reaction types among the Michael reactions is the conjugated addition of malonates to enones making it possible to ...
Péter Bakó   +3 more
semanticscholar   +1 more source

(–)-Dimenthyl malonate

Acta Crystallographica Section C Crystal Structure Communications, 2002
The title compound, bis(2-isopropyl-5-methylcyclohex-1-yl) malonate, C(23)H(40)O(4), crystallizes in the monoclinic space group P2(1). In the crystal, the molecule is not C(2) symmetric.
Gregory S, Coumbarides   +3 more
openaire   +2 more sources

Mechanochemical Copper-Catalyzed Asymmetric Michael-Type Friedel-Crafts Alkylation of Indoles with Arylidene Malonates.

Chemistry, 2019
A mechanochemical version of the asymmetric Michael-type Friedel-Crafts alkylation of indoles with arylidene malonates was developed. The reaction proceeds under ambient atmosphere using a chiral bis(oxazoline)copper catalyst in a mixer mill. Under these
Plamena Staleva   +2 more
semanticscholar   +1 more source

Air- and Light-Stable S-(Difluoromethyl)sulfonium Salts: C-Selective Electrophilic Difluoromethylation of β-Ketoesters and Malonates.

Organic Letters, 2018
Air- and light-stable electrophilic difluoromethylating reagents, S-(difluoromethyl)- S-phenyl- S-(2,4,6-trialkoxyphenyl) sulfonium salts were successfully developed, and the introduction of intramolecular hydrogen bonds plays a crucial role for the ...
Sheng-Le Lu   +6 more
semanticscholar   +1 more source

Malonate and Plant Respiration

Nature, 1947
Since Quastel and Whetham's discovery in 19251, biochemists have come to regard the malonate ion as one of the very few specific enzyme inhibitors—as a competitive inhibitor of succinic dehydrogenase2 Malonate has therefore been widely used with animal tissue, in work designed to elucidate the Krebs cycle.
Vera F. Hanly, J. S. Turner
openaire   +3 more sources

Synergistic Brønsted Base/Photoredox‐Catalyzed Three‐Component Coupling with Malonates to Synthesize δ‐Hydroxy Esters and δ‐Keto Esters

Chinese journal of chemistry
Multicomponent alkene 1,2‐dicarbofunctionalizations (DCFs) have emerged as a powerful strategy to rapidly incorporate both two carbon subunits across one C—C double bond in one step for enhancing molecular complexity and diversity.
Ting Li   +7 more
semanticscholar   +1 more source

Decomposition of Malonic Anhydrides

Journal of the American Chemical Society, 2012
Malonic anhydrides decompose at or below room temperature, to form a ketene and carbon dioxide. Rate constants for the thermal decomposition of malonic, methylmalonic, and dimethylmalonic anhydrides were measured by NMR spectroscopy at various temperatures, and activation parameters were evaluated from the temperature dependence of the rate constants ...
Marlon N. Manalo   +2 more
openaire   +3 more sources

Malonic aciduria and cardiomyopathy

Journal of Inherited Metabolic Disease, 1993
Malonyl-CoA decarboxylase (EC 4.1.1.9) deficiency (McKusick 248360) with malonic aciduria was first reported by Brown et al (1984) in a patient with short stature, repeated episodes of vomiting and mild developmental delay. A second patient with malonic aciduria and malonyl-CoA decarboxylase deficiency was reported by Haan et al (1986).
David R. Thorburn   +6 more
openaire   +2 more sources

Role of malonate in chickpeas

Phytochemistry, 2000
Analysis of the content and distribution of organic acids in chickpea plants (Cicer arietinum L.) showed that malonate was the most abundant acid in roots and nodules, whereas malate was the main acid in leaves and stems. The highest concentration of malonate in roots was in the apices.
Jun Li, Les Copeland
openaire   +3 more sources

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