Results 81 to 90 of about 74,095 (228)
Model of maltose-binding protein/chemoreceptor complex supports intrasubunit signaling mechanism [PDF]
Proceedings of the National Academy of Sciences, 1999 The Tar protein of Escherichia coli is unique among known bacterial chemoreceptors in that it generates additive responses to two very disparate ligands, aspartate and maltose. Aspartate binds directly to the periplasmic (extracytoplasmic) domain of Tar. Maltose first binds to maltose-binding protein (MBP). MBP then
Y, Zhang +5 more
openaire +2 more sources
Structural basis of TFIIH activation for nucleotide excision repair. [PDF]
, 2019 Nucleotide excision repair (NER) is the major DNA repair pathway that removes UV-induced and bulky DNA lesions. There is currently no structure of NER intermediates, which form around the large multisubunit transcription factor IIH (TFIIH).
Chernev, A. +5 more
core +2 more sources
Stimulation of the Maltose Transporter ATPase by Unliganded Maltose Binding Protein [PDF]
Biochemistry, 2009 ATP hydrolysis by the maltose transporter (MalFGK(2)) is regulated by maltose binding protein (MBP). Binding of maltose to MBP brings about a conformational change from open to closed that leads to a strong stimulation of the MalFGK(2) ATPase. In this study, we address the long-standing but enigmatic observation that unliganded MBP is also able to ...
Gould, Alister D. +2 more
openaire +4 more sources
Several Affinity Tags Commonly Used in Chromatographic Purification
Journal of Analytical Methods in Chemistry, 2013 Affinity tags have become powerful tools from basic biological research to structural and functional proteomics. They were widely used to facilitate the purification and detection of proteins of interest, as well as the separation of protein complexes ...
Xinyu Zhao, Guoshun Li, Shufang Liang
doaj +1 more source
Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels? [PDF]
, 2003 The regulation of ion channels by anionic phospholipids is currently very topical. An outstanding issue is whether phosphatidylinositol 4,5-diphosphate and related species act as true second messengers in signaling or behave in a manner analogous to an ...
Clapp, LH +4 more
core +1 more source
Virology JournalHuman papillomavirus (HPV) infection poses a significant threat to public health worldwide. Targeting the function of HPV E6 and E7 proteins and activating the host immune response against these proteins represent promising therapeutic strategies for ...
Mei-nian Xu +6 more
doaj +1 more source
Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2. [PDF]
, 2017 The HORMA domain is a highly conserved protein-protein interaction module found in eukaryotic signaling proteins including the spindle assembly checkpoint protein Mad2 and the meiotic HORMAD proteins.
Corbett, Kevin D +2 more
core +2 more sources
Adaptive response of neonatal sepsis-derived Group B Streptococcus to bilirubin [PDF]
, 2018 This work was funded by the Neonatal Unit Endowment Fund, Aberdeen Maternity Hospital. RH is funded by a career researcher fellowship from NHS Research Scotland. SG was funded by the MRC Flagship PhD programme.
Berry, Susan +10 more
core +4 more sources
BMC Biotechnology, 2020 Background Few bead-based multiplex assays have been described that detect antibodies against the protozoan parasite Toxoplasma gondii in large-scale seroepidemiological surveys. Moreover, each multiplex assay has specific variations or limitations, such
Sandra Klein, Daniel Stern, Frank Seeber
doaj +1 more source
Journal of Sugarcane Research, 2020 The occurrence of Sugarcane streak mosaic virus (SCSMV), characterized as ‘Susmovirus’, a Potyviridae member, was recently reported in India. The virus as identified as one of the causative agents of mosaic in sugarcane along with Sugarcane ...
R. Viswanathan +2 more
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