Length, Protein-Protein Interactions, and Complexity [PDF]
, 2004 The evolutionary reason for the increase in gene length from archaea to prokaryotes to eukaryotes observed in large scale genome sequencing efforts has been unclear. We propose here that the increasing complexity of protein-protein interactions has driven the selection of longer proteins, as longer proteins are more able to distinguish among a larger ...
arxiv +1 more source
A Strong and Water‐Retaining Biomass Adhesive Inspired by Tofu
Advanced Functional Materials, EarlyView.Drawing inspiration from the formation mechanism of the traditional food tofu, a strong and water‐retaining adhesive is designed using the soybean meal (SM) oxidized by glucose oxidase (GOx) and calcium sulfate oligomer (CSO). This design strategy effectively addresses the conflicting requirements of water‐resistant bonding strength and water retention
Jiawei Shao +8 more
wiley +1 more source
Stubborn contaminants: influence of detergents on the purity of the multidrug ABC transporter BmrA. [PDF]
PLoS ONE, 2014 Despite the growing interest in membrane proteins, their crystallization remains a major challenge. In the course of a crystallographic study on the multidrug ATP-binding cassette transporter BmrA, mass spectral analyses on samples purified with six ...
Benjamin Wiseman +6 more
doaj +1 more source
Development of an electrochemical maltose biosensor [PDF]
, 2012 In this work, electrochemical maltose biosensors based on mutants of the maltose binding protein (MBP) are developed. A ruthenium II complex (Ru II ), which is covalently attached to MBP, serves as an electrochemical reporter of MBP conformational ...
García García, Alfonso +3 more
core +1 more source
Bind-n-Seq: high-throughput analysis of in vitro protein-DNA interactions using massively parallel sequencing. [PDF]
, 2009 Transcription factor-DNA interactions are some of the most important processes in biology because they directly control hereditary information. The targets of most transcription factor are unknown.
Korf, Ian +2 more
core +2 more sources
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials, EarlyView.Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan +4 more
wiley +1 more source
High‐Fidelity In Vitro Packaging of Diverse Synthetic Cargo into Encapsulin Protein Cages
Angewandte Chemie, EarlyView.Pack n’ Play. A novel in vitro assembly system for encapsulin protein cages has been developed. Using a bulky fusion partner to prevent shell assembly in cellulo, high‐fidelity assembly is triggered in vitro by proteolytic cleavage yielding robust particles with superior thermostability.
Taylor N. Szyszka +8 more
wiley +2 more sources
ProNet DB: A proteome-wise database for protein surface property representations and RNA-binding profiles [PDF]
arXiv, 2022 The rapid growth in the number of experimental and predicted protein structures and more complicated protein structures challenge users in computational biology for utilizing the structural information and protein surface property representation. Recently, AlphaFold2 released the comprehensive proteome of various species, and protein surface property ...
arxiv
ATPase Regulation in the Maltose Transporter [PDF]
, 2011 This thesis investigates the mechanism of activity-coupling in the maltose transporter of Escherichia coli (MalFGK2); the way ATP hydrolysis is prevented in the absence of maltose, and then enabled to drive maltose transport.
Gould, Alister D
core +1 more source
Regulation of eosinophilia and allergic airway inflammation by the glycan-binding protein galectin-1 [PDF]
, 2016 Galectin-1 (Gal-1), a glycan-binding protein with broad antiinflammatory activities, functions as a proresolving mediator in autoimmune and chronic inflammatory disorders. However, its role in allergic airway inflammation has not yet been elucidated.
Abramoff +15 more
core +1 more source