Results 111 to 120 of about 14,055 (248)

Differential Water Networks Guide Selectivity Optimization of a Cell Active BPTF Inhibitor in Neuroblastoma

Angewandte Chemie, EarlyView.
BZ2 is a second‐generation Bromodomain PHD finger Transcription Factor (BPTF) inhibitor with improved selectivity over Class I and Class IV BRD off‐targets identified in our previously reported inhibitor, BZ1. Structural analyses reveal that water network engagement is key to this selectivity.
Kesavan Babu, Chun‐Ju Tsou, Sourav Das, Liying Fan, Anasuya Pal, Molly Sneddon, Timothy R. Stachowski, Priyanka Samanta, Stanley Nithianantham, Caroline Buchholz, Shi Zhang, Xiang Fu, Rahul S. Kathayat, Wenwei Lin, Yongtao Li, Lei Yang, Taosheng Chen, Marcus Fischer, Anang A. Shelat, William C. K. Pomerantz   +19 more
wiley   +2 more sources

Comparative analysis of TP53 gene in Tupaia belangeri subspecies (Tupaia belangeri yaoshanensis vs. Tupaia belangeri chinensis) and identification of mutations in spontaneous tumor cases

Animal Models and Experimental Medicine, EarlyView.
This study provides the first evidence of natural TP53 variation between tree shrew subspecies and identifies somatic TP53 mutations in spontaneous tree shrew sarcomas. The high structural and functional conservation of tree shrew p53 with humans supports its utility as a relevant model for TP53‐related cancer research.
Yingying Cao, Haibo Tang, Liang Liang, Jing Leng, Weijian Huang   +4 more
wiley   +1 more source

Regeneration‐Optimized Chemisorbents: Evaluating Hybrid Coordination Networks for Atmospheric Water Harvesting

Angewandte Chemie, EarlyView.
Atmospheric water harvesting (AWH) under arid conditions requires desiccants that load water below 30% RH and regenerate below 60°C, a performance regime traditionally limited to physisorbents. Here, we show that the inherent hydrolytic instability of M′FSIX‐25‐M coordination networks enable regeneration‐optimized chemisorbents (ROCs) with projected ...
Xiang‐Jing Kong, Asif Raza, Lilia Croitor, Andrey Bezrukov, Xia Li, Angela Shipman, William Morris, Carlos J. Solanilla‐Salinas, Adam Hogan, Brian Space, Volodymyr Bon, Stefan Kaskel, Soumya Mukherjee, Alan C. Eaby, Tao He, Michael J. Zaworotko   +15 more
wiley   +2 more sources

Transforming Growth Factor Beta 2 (TGFß2) and Dehydroepiandrosterone Sulphate (DHEAs) Levels in Breast Macrocyst Fluids. Different Behaviour According to Cyst Type

The International Journal of Biological Markers, 1998
A. Ruibal, M.I. Nuñez, J. Schneider, M C. Del Rio, F. Rabadan, A. Tejerina   +5 more
doaj   +1 more source

Suicide, quality of life, and psychotropic medication use in women with breast cancer. [PDF]

Rev Bras Enferm
Carvalho LFF, Miasso AI.
europepmc   +1 more source

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

Atroposelective Pd(0)‐Catalyzed Direct Intermolecular C─H Arylation of Thiazole N‐Oxides Provides Access to Heterobiaryls

Angewandte Chemie, EarlyView.
An enantioselective Pd(0)‐catalysed arylation at the C4‐position of thiazole N‐oxides directly forges the atropochiral heterobiaryl axis. A tailored point‐ and axially chiral monodentate phosphine ensures high reactivities along with a tight stereocontrol.
Vitalii Smal, Nicolai Cramer
wiley   +2 more sources

Can AI Detect What Is Not Injected? Evaluation of Lesion Detection in Virtual Contrast-Enhanced Breast MRI Using a Large-Scale AI Model Trained on GBCA-Enhanced Data. [PDF]

Tomography
Heidarikahkesh S, Schreiter H, George A, Nguyen TT, Skwierawska D, Brock L, Hadler D, Uder M, Laun FB, Ehring C, Graber J, Döppmann L, Horishnyi I, Kapsner LA, Ohlmeyer S, Liebert A, Bickelhaupt S.   +16 more
europepmc   +1 more source

Nanofabricated Biomaterials Model Tumor Extracellular Matrix Topography

Advanced NanoBiomed Research, EarlyView.
The unique structure and composition of the tumor microenvironment and its associated extracellular matrix (ECM) exert profound effects on cancer cell behavior that are difficult to model in vitro. This perspective discusses the utility of nanofabricated biosubstrates, such as the novel collagen‐coated nanogrooved array, for recapitulating the ...
Vic Zamloot, JinSeok Park
wiley   +1 more source

Deprotonation and Alkylation of Weakly Acidic C(sp3)─H Bonds Through In Situ Generation of a Strong Hydride Base From 1,1,3,3‐Tetramethyldisiloxane and Potassium tert‐Butoxide

Angewandte Chemie, EarlyView.
The use of 1,1,3,3‐tetramethyldisiloxane (TMDSO) and potassium tert‐butoxide enables direct alkylation of weakly acidic carbon–hydrogen bonds with alkyl halides. Experimental and computational studies support the formation of a substrate‐associated hydride‐like base, providing a single‐step alternative to the classical deprotonation and electrophile ...
Piers St. Onge, Brandon White, Han Yao, Travis Dudding, Stephen G. Newman   +4 more
wiley   +2 more sources