Results 91 to 100 of about 377,358 (296)

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Quistes mamarios: claves radiológicas para un diagnóstico diferencial preciso y manejo efectivo

Anales de Radiología, México
Objetivo: Analizar las características ecográficas de los quistes mamarios y su clasificación según el sistema BI-RADS (Breast Imaging-Reporting and Data System) para optimizar su diagnóstico diferencial y manejo clínico.
Sergio D. Gálvez-Vieyra, Juan L. Ortiz-León, Variny K. Muñoz-Bautista, José L. Martínez-Pérez, Cristell E. Arjona-Villanueva, Jesús Pérez-Alcalá   +5 more
doaj   +1 more source

Magnetosome vesicles are present before magnetite formation, and MamA is required for their activation [PDF]

, 2004
Bacterial magnetosomes are intracellular compartments that house highly ordered magnetite crystals. By using Magnetospirillum sp. AMB-1 as a model system, we show that magnetosome vesicles exist in the absence of magnetite, biomineralization of magnetite
Beveridge, Terrance J., Komeili, Arash, Newman, Dianne K., Vali, Hojatollah   +3 more
core  

Episodic Star Formation Coupled to Reignition of Radio Activity in 3C 236 [PDF]

, 2010
We present Hubble Space Telescope UV and optical imaging of the radio galaxy 3C 236, whose relic 4 Mpc radio jet lobes and inner 2 kpc CSS radio source are evidence of multiple epochs of AGN activity. Our data confirm the presence of four bright knots of
Adelman-McCarthy, Alexander, Allen, Anton M. Koekemoer, Arno P. Schoenmakers, Barnes, Baum, Bekki, Bell, Brocksopp, Christopher P. O'Dea, Ciotti, de Koff, de Koff, Donzelli, Dopita, Faber, Fanaroff, Ferrarese, Floyd, Gebhardt, Ger de Bruyn, Grant R. Tremblay, Gunn, Haehnelt, Hopkins, Hopkins, Jones, Koekemoer, Koekemoer, Kormendy, Lauer, Leitherer, Machalski, Madrid, Magorrian, Martel, Maybhate, McCarthy, O'Dea, Osterbrock, Parma, Privon, Pérez-González, Rees, Scannapieco, Schmidt, Silk, Silverman, Stefi A. Baum, Tran, Tremblay, Tremblay, Vázquez, William B. Sparks, Wuyts, York, Zirbel   +57 more
core   +2 more sources

Engineered Bacteria Factory Integrating Drug Delivery and Antibody Manufacture for Activating the STING Signal Pathway Mediated Tumor Immunotherapy

Advanced Science, EarlyView.
To address the limitations of protein‐based ICIs in applications, this study constructed an engineered bacterium, HRB, capable of expressing aCD47 in hypoxic TME. Through the Schiff base reaction, responsive liposomes (LC) loaded with the STING agonist cGAMP were connected to the surface of bacteria to form HRB@LC.
Peng‐Shuo Dong, Tian Yao, Yong Li, Zi‐Hui Yan, Xiao‐Ting Xie, Jia‐Hua Zou, Kai Cheng, Jin‐Xuan Fan, Yuan‐Di Zhao, Qiu‐Ran Xu   +9 more
wiley   +1 more source

Technical Innovation and Chest Symmetrizing Techniques in Masculinizing Top Surgery: The Author’s Experience

Plastic and Reconstructive Surgery, Global Open
Background:. Masculinizing top surgery (masculinizing mastectomy, thoracoplasty, or mammoplasty) is the most commonly performed gender-affirming surgical procedure for transmasculine individuals. This study presents 3 surgical chest contouring techniques,
Patricia A. Bellini, MD, MSc, Daniela B. Corrêa, MD, MSc, Thereza C. Ranção, MD, Mariana S.F. Silva, MD, Luiz Ronaldo Alberti, MD, MSc, PhD, Aleida Nazareth Soares, MSc, PhD   +5 more
doaj   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Benign breast diseases in men beyond gynecomastia

Journal of the Mexican Federation of Radiology and Imaging
Introduction: Benign breast diseases in men, other than gynecomastia, are poorly understood due to their low prevalence. This study describes the clinical characteristics, mammographic and ultrasound (US) findings, and the histology of benign breast ...
Abraham Ortiz-Garcia, L. Leticia Rosales-Rosales, Javier Hernandez-Hernandez   +2 more
doaj   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

"Goldilocks and the Three Bears" [PDF]

Unlike the Papa, Mama, and Baby Bears faced by the storybook Goldilocks, our Goldilocks faced three ferocious grizzlies: a cascading, global financial crisis; global deflation and excess capacity (or insufficient demand); and a domestic fiscal surplus in
L. Randall Wray
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