Results 81 to 90 of about 14,055 (248)

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Technical Innovation and Chest Symmetrizing Techniques in Masculinizing Top Surgery: The Author’s Experience

Plastic and Reconstructive Surgery, Global Open
Background:. Masculinizing top surgery (masculinizing mastectomy, thoracoplasty, or mammoplasty) is the most commonly performed gender-affirming surgical procedure for transmasculine individuals. This study presents 3 surgical chest contouring techniques,
Patricia A. Bellini, MD, MSc, Daniela B. Corrêa, MD, MSc, Thereza C. Ranção, MD, Mariana S.F. Silva, MD, Luiz Ronaldo Alberti, MD, MSc, PhD, Aleida Nazareth Soares, MSc, PhD   +5 more
doaj   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Radiation‐Triggered Chemokine‐Secreting Probiotics for Boron Neutron Capture Therapy Based Radioimmunotherapy

Advanced Science, EarlyView.
Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Yang Liu, Yuzhong Qian, Shaobo Huang, Bingbing Li, Yue Yu, Xiang Cheng, Chang Chen, Jiheng Wang, Maosong Yang, Lizheng Liang, Xiancai Meng, Zhigang Liu   +11 more
wiley   +1 more source

Cancer Health Disparities Among Patients With Early-Stage Estrogen Receptor–Positive Breast Cancer: Impact of Public Versus Private Health Care on Diagnosis-to-Treatment Interval in Brazil

JCO Global Oncology
PURPOSEIn 2013, Brazil implemented a federal law (Law 12.732/2012) mandating cancer treatment to begin within 60 days of diagnosis. Among women with newly diagnosed estrogen receptor–positive (ER+) nonmetastatic breast cancer, we describe the diagnosis ...
Romualdo Barroso-Sousa, Danielle Laperche-Santos, Heloisa Resende, Fernanda Cesar Moura, Sulene Cunha Sousa Oliveira, Andrea Kazumi Shimada, Renata Arakelian, Anna Luiza Zapalowski Galvão, Bruno Santos Wance de Souza, Amanda Guimarães Castro Custodio, Monalisa Ceciliana Freitas Moreira de Andrade, Yuri Cardoso Rodrigues Beckedorff Bittencourt, Maria Cristina Figueroa Magalhães, Cristiano de Pádua Souza, Carlos Eduardo Paiva, Poliana Albuquerque Signorini, Daniela Jessica Pereira, Angélica Nogueira-Rodrigues, Daniela Dornelles Rosa, Brittany Bychkovsky, Daniele Assad-Suzuki   +20 more
doaj   +1 more source

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

Advanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao, Jinpei Sun, Chenxi Zhao, Yuting Cang, Keyu Zong, Yuxin Guo, Yajing Wang, Di Meng, Qingling Song, Lei Wang   +9 more
wiley   +1 more source

Academic Collaborative Groups in Latin America: Key for High-Quality Standards and Personal and Collective Growth

JCO Global Oncology
Latin America's cultural diversity, political instability, and socioeconomic inequality contribute to fragmented health systems, hindering high-quality care and health equity.
Pablo Mandó, Federico Waisberg, Gonzalo Gomez Abuin, María Victoria Costanzo, Valeria Caceres, Andrés F. Cardona, Carlos Barrios   +6 more
doaj   +1 more source

Ultrasound‐Activated Nanoinhibitors Blocking the Chemo‐Immune Checkpoint to Overcome Chemotherapy‐Induced Immune Resistance

Advanced Science, EarlyView.
A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng, Hao Yang, Xun Guo, Jianli Ren, Zhiyi Zhou   +13 more
wiley   +1 more source

Young children's perspectives of time: New directions for co‐constructing understandings of quality in ECEC

British Educational Research Journal, EarlyView., 2023
Abstract Children's relationship with time in preschools is an under‐researched area. Young children rarely know how to measure time using a clock, but their experiences of time may contribute to understanding children's well‐being and debates about quality in preschools.
Kristín Dýrfjörð, Anna Magnea Hreinsdóttir, Adrijana Visnjic‐Jevtic, Alison Clark   +3 more
wiley   +1 more source

Mathematical Model of Alcoholism Incorporating Treatment: A Case Study in Kenya

Journal of Mathematics Instruction, Social Research and Opinion
Alcoholism is characterized by persistent and uncontrollable consumption of alcoholic beverages, which poses significant risks to physical, psychological, and emotional health, including conditions such as liver cirrhosis, epilepsy, cancer, hypertension,
Samuel Chege, Mark O. Okongo, Jimrise O. Ochwach   +2 more
doaj   +1 more source