Results 141 to 150 of about 374,047 (298)

Cells Dynamically Adapt Their Nuclear Volumes and Proliferation Rates During Single to Multicellular Transitions

Advanced Science, EarlyView.
It is currently not well understood how cells regulate basic properties, e.g., volume and mechanics within dense multicellular environments like tumors. Here, we show that different cell types of cancer and also normal cells largely decrease their nuclear and cellular volumes in emerging cell clusters and that this is partly driven by cell cycle shifts.
Vaibhav Mahajan, Keshav Gajendra Babu, Markus Mukenhirn, Antje Garside, Vinita Ajit Kini, Trishla Adhikari, Timon Beck, Byung Ho Lee, Kyoohyun Kim, Carsten Werner, Raimund Schlüßler, Alf Honigmann, Sebastian Aland, Anna Verena Taubenberger   +13 more
wiley   +1 more source

Long‐term prognosis is associated with residual disease after neoadjuvant systemic therapy but not with initial nodal status

BJS (British Journal of Surgery), EarlyView., 2020
This long‐term follow‐up study determined survival rates in a Swedish national cohort of 417 patients with breast cancer who all had neoadjuvant systemic therapy (NAST). Sentinel lymph node biopsy (SLNB) was performed before NAST in clinically node‐negative and after NAST in clinically node‐positive patients.
L. Zetterlund, F. Celebioglu, T. Hatschek, J. Frisell, J. de Boniface   +4 more
wiley   +1 more source

Redox‐Responsive Polymeric Nanocapsules for Enhanced Tumor‐Targeted Delivery of Antimicrobial Peptides

Advanced Science, EarlyView.
This study presents a modular redox‐responsive nanocapsule platform that enables enhanced tumor‐targeted delivery of antimicrobial peptides. Using melittin as an example, the system achieves controlled activation within the tumor microenvironment, improving intratumoral accumulation while minimizing systemic toxicity.
Lin Tang, Yajian Li, Xiaoyin Lv, Jianmei Guo, Yijia Zhang, Yuqi Lin, Kaili Nie, Jian Zeng, Ming Zhang, Qiong Dai   +9 more
wiley   +1 more source

Changes in Alcohol Retail Laws and Foot Traffic at Liquor Stores

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT We study how expanding alcohol availability at grocery and convenience stores affects consumer traffic in liquor stores by leveraging recent changes in state‐level alcohol distribution laws in a difference‐in‐difference quasi‐experimental design.
Nathan Palardy, Marco Costanigro, Joshua Berning, Jude Bayham   +3 more
wiley   +1 more source

“Will you be there for me?” Social support from family and friends during cold case sexual assault prosecutions

American Journal of Community Psychology, EarlyView.
Abstract If sexual assault survivors report the assault to the criminal legal system, they often need informal support from family and friends throughout the long and frequently retraumatizing process of investigation and prosecution. This study is part of a long‐term community‐based participatory action research project in a predominately Black ...
Rebecca Campbell, Rachael Goodman‐Williams, Katie Gregory, McKenzie Javorka, Jasmine Engleton   +4 more
wiley   +1 more source

Patient Perspectives on Psychiatric Polygenic Risk Scores in Reproductive Decision‐Making and Polygenic Embryo Screening

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Polygenic risk scores (PRS) estimate individuals' genetic risk for developing multifactorial conditions. Recent genome‐wide association studies have enabled development of psychiatric PRS, which hold potential to streamline diagnosis and treatment of psychiatric conditions.
Lauren A. Ginn, Amanda R. Merner, Page M. Trotter, Kaitlynn P. Craig, Abigail C. Martinez, Ana Lucía Battaglino, Dorit Barlevy, Daphne M. Ayton, Takahiro Soda, Eric A. Storch, Gabriel Lázaro‐Muñoz, Stacey Pereira   +11 more
wiley   +1 more source

Transforming Growth Factor Beta 2 (TGFß2) and Dehydroepiandrosterone Sulphate (DHEAs) Levels in Breast Macrocyst Fluids. Different Behaviour According to Cyst Type

The International Journal of Biological Markers, 1998
A. Ruibal, M.I. Nuñez, J. Schneider, M C. Del Rio, F. Rabadan, A. Tejerina   +5 more
doaj   +1 more source

Homozygous Achondroplasia With Long‐Term Survival: Growth Patterns, Medical Interventions, and Practice Implications

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Homozygous achondroplasia is widely considered perinatal lethal by the medical community. In this case series, we report two children from a single family with longer‐term survival. One child lived for 17 months and the other was 60 months at the time of publication.
Hannah Singerline, Jason Laufman, Kimberly Wallis, Michelle Merrill   +3 more
wiley   +1 more source

Tracking the Dynamics of human Colonisation and Adaptation in Central Vanuatu: Preliminary Results From Excavation and Survey at Pangpang, East Efate

Archaeology in Oceania, EarlyView.
ABSTRACT In October 2022 an extensive archaeological landscape was identified by staff of the Vanuatu Cultural Centre at Pangpang on the east coast of Efate Island in central Vanuatu. It included midden deposits on the banks of the Pangpang River near the sea at Forari Bay where Lapita and Early Erueti‐style pottery sherds were recovered.
Stuart Bedford, Iarawai Phillip, Lucas Sarvanu, Edson Willie, Stuart Hawkins, Robert Henderson, Frédérique Valentin, Siri Seoule, Emily Nutman, Phillip Parton   +9 more
wiley   +1 more source

Evaluation of breast cancer symptoms and risk factors in women: the case of Türkiye. [PDF]

Rev Esc Enferm USP
Ahi S, Ayata MK, Seyhan M.
europepmc   +1 more source