Results 71 to 80 of about 165,269 (210)
TREM2-dependent effects on microglia in Alzheimer\u27s Disease [PDF]
, 2018 Alzheimer’s disease (AD) is a late-onset dementia characterized by the deposition of amyloid plaques and formation of neurofibrillary tangles (NFTs) which lead to neuronal loss and cognitive deficits.
Colonna, Marco +2 more
core +3 more sources
Mammalian target of rapamycin inhibition in hepatocellular carcinoma
World Journal of Hepatology, 2014 Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. It is associated with a poor prognosis and has limited treatment options. Sorafenib, a multi-targeted kinase inhibitor, is the only available systemic agent for treatment of HCC that improves overall survival for patients with advanced stage disease ...
René E, Ashworth, Jennifer, Wu
openaire +2 more sources
BMC Cancer, 2017 Background Mesothelioma is resistant to conventional treatments and is often defective in p53 pathways. We then examined anti-tumor effects of metformin, an agent for type 2 diabetes, and combinatory effects of metformin and nutlin-3a, an inhibitor for ...
Kengo Shimazu +9 more
doaj +1 more source
The role of RICTOR downstream of receptor tyrosine kinase in cancers
Molecular Cancer, 2018 The importance of the network defined by phosphatidylinositol-3-kinase (PI3K), AKT and mammalian target of rapamycin (mTOR) downstream of Receptor Tyrosine Kinase (RTK) has been known for many years but the central role of RICTOR (rapamycin-insensitive ...
Ahlem Jebali, Nicolas Dumaz
doaj +1 more source
Az mTOR (mammalian target of rapamycin) aktivitás jelentősége humán lymphomákban [PDF]
, 2014 Neoplastic processes, tumor growth, and tumor cell proliferation and survival are often due to the altered activation of different signaling pathways. The increased activity of PI3K/AKT/mTOR signaling has been shown to be an important regulator of tumor ...
Márk, Ágnes
core +2 more sources
Clinical Case Reports, 2017 Key Clinical Message Temsirolimus did not demonstrate an efficacy advantage compared with sorafenib as second‐line therapy in patients with metastatic renal cell carcinoma (mRCC).
Tendo Satoh +5 more
doaj +1 more source
A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus [PDF]
, 2002 Many forms of long-lasting behavioral and synaptic plasticity require the synthesis of new proteins. For example, long-term potentiation (LTIP) that endures for more than an hour requires both transcription and translation.
Gingras, Anne-Claude +5 more
core
Deletion of Tsc2 in nociceptors reduces target innervation, ion channel expression, and sensitivity to heat [PDF]
, 2018 The mechanistic target of rapamycin complex 1 (mTORC1) is known to regulate cellular growth pathways, and its genetic activation is sufficient to enhance regenerative axon growth following injury to the central or peripheral nervous systems.
Carlin, Dan +6 more
core +2 more sources
mTORC2 Deficiency Alters the Metabolic Profile of Conventional Dendritic Cells
Frontiers in Immunology, 2019 In myeloid dendritic cells (DC), deletion of the mechanistic target of rapamycin complex 2 (TORC2) results in an augmented pro-inflammatory phenotype and T cell stimulatory activity; however, the underlying mechanism has not been resolved.
Alicia R. Watson +13 more
doaj +1 more source