Results 91 to 100 of about 240,144 (264)
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
, 1982 (Uploaded by Plazi for the Bat Literature Project) No abstract provided.
openaire +2 more sources
, 1996 age of mammals; San Juan basin; New Mexico; biostratigraphy; evolution; Paleocene; Nacimiento ...
Thomas E. Williamson
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Overview of Cancer Resistance Mechanisms Observed in Mammals [PDF]
openCancer is a global health challenge, affecting various species across the mammalian kingdom and it is a complex and ubiquitous disease characterized by uncontrolled cell growth with the potentiality to disrupt the physiological integrity of an ...
VISENTIN, ELEONORA
core
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Movement EcologyBackground Information on reproductive success is crucial to understanding population dynamics but can be difficult to obtain, particularly for species that birth while denning. For grizzly (Ursus arctos) and polar bears (U.
Erik M. Andersen +11 more
doaj +1 more source
Trans-Atlantic movements of Atlantic white-sided dolphins, Leucopleurus acutus
Frontiers in Marine ScienceAtlantic white-sided dolphins are wide-ranging and abundant cetaceans of the North Atlantic, yet their movements remain poorly understood. Using satellite telemetry, we tracked 23 dolphins tagged in the Faroe Islands to investigate their movement ...
Sara De Clerck +6 more
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Ecology and EvolutionMovement is a fundamental aspect of animal ecology that varies across space, time, and among individuals or groups within a population. Broad‐scale patterns of animal movement are often classified into different movement strategies, such as resident ...
Storm Crews +7 more
doaj +1 more source