Results 91 to 100 of about 1,142,661 (285)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Hierarchy in Structuring of Resource Selection: Understanding Elk Selection Across Space, Time, and Movement Strategies

Ecology and Evolution
Movement is a fundamental aspect of animal ecology that varies across space, time, and among individuals or groups within a population. Broad‐scale patterns of animal movement are often classified into different movement strategies, such as resident ...
Storm Crews, Nathaniel D. Rayl, Mathew W. Alldredge, Eric J. Bergman, Chuck R. Anderson Jr., Eric H. VanNatta, Joseph D. Holbrook, Guillaume Bastille‐Rousseau   +7 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Historic and Current Use of Lower Cook Inlet, Alaska, by Belugas, Delphinapterus leucas [PDF]

, 2000
Dedicated at-sea surveys for marine birds and mammals conducted in lower Cook Inlet in late July and early August from 1995–99 failed to locate any belugas, Delphinapterus leucas.
Piatt, John F., Speckman, Suzann G.
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Identifying presence or absence of grizzly and polar bear cubs from the movements of adult females with machine learning

Movement Ecology
Background Information on reproductive success is crucial to understanding population dynamics but can be difficult to obtain, particularly for species that birth while denning. For grizzly (Ursus arctos) and polar bears (U.
Erik M. Andersen, Justin G. Clapp, Milan A. Vinks, Todd C. Atwood, Daniel D. Bjornlie, Cecily M. Costello, David D. Gustine, Mark A. Haroldson, Lori L. Roberts, Karyn D. Rode, Frank T. van Manen, Ryan R. Wilson   +11 more
doaj   +1 more source

Ecosystem-based Management for Protected Species in the North Pacific Fisheries [PDF]

, 2011
In the North Pacific Ocean, an ecosystem-based fishery management approach has been adopted. A significant objective of this approach is to reduce interactions between fishery-related activities and protected species.
Heltzel, Jeannie M., Wilson, William J., Witherell, David   +2 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Characterization of North Carolina commercial fisheries with occasional interactions with marine mammals [PDF]

, 2001
In accordance with the Marine Mammal Protection Act (MMPA, 16 U.S.c. et seq.), the National Marine Fisheries Service (NMFS) is required to publish an annual List of Fisheries (LOF) which categorizes U.S.
Borggaard, Diane, Gearhart, Jeff, Hohn, Aleta A., Sabo, Lees, Steve, Carolyn   +4 more
core