Results 81 to 90 of about 1,142,661 (285)

Humans and dolphins: Decline and fall of adult neurogenesis [PDF]

, 2018
Pre-clinical research is carried out on animal models, mostly laboratory rodents, with the ultimate aim of translating the acquired knowledge to humans.
Bonfanti, Luca, Cozzi, Bruno, Parolisi, Roberta   +2 more
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Electrochemotherapy with bleomycin of different types of cutaneous tumours in a ferret (Mustela putorius furo)

Radiology and Oncology, 2017
Mast cell tumour, sebaceous gland adenoma, and less common squamous papilloma are skin tumours in ferrets (Mustela putorius furo), and early excisional surgery is usually the treatment of choice.
Racnik Jozko, Svara Tanja, Zadravec Marko, Gombac Mitja, Cemazar Maja, Sersa Gregor, Tozon Natasa   +6 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

The complete mitochondrial genome of the critically endangered Atlantic humpback dolphin, Sousa teuszii (Kükenthal, 1892)

Mitochondrial DNA. Part B. Resources, 2020
The Atlantic humpback dolphin remains an understudied, critically endangered cetacean species. Here, we describe the first complete mitogenome of Sousa teuszii, derived from an animal stranded on Île des Oiseaux, Sine Saloum, Senegal. The S.
Michael R. McGowen, Katherine R. Murphy, Ibrahima Ndong, Charles W. Potter, Lucy W. Keith-Diagne   +4 more
doaj   +1 more source

Assessing the umbrella value of a range-wide conservation network for Jaguars (Panthera onca) [PDF]

, 2016
Umbrella species are employed as conservation short-cuts for the design of reserves or reserve networks. However, empirical data on the effectiveness of umbrellas is equivocal, which has prevented more widespread application of this conservation strategy.
Adriaensen, Alan Rabinowitz, Andelman, Angelo, Beier, Beier, Bifolchi, Branton, Branton, Brodie, Brodie, Brooks, Carlo Rondinini, Caro, Caro, Carroll, Carroll, Che-Castaldo, Christopher Burdett, Crooks, Crooks, Cushman, Daniel Thornton, Epps, Fleishman, Fleishman, Gardner, Groves, Heller, Howard Quigley, Hughes, Hurme, Kathy Zeller, Kevin Crooks, Lindenmayer, Luigi Boitani, Mac Nally, Minor, Noss, Oliver, Petracca, Pressey, Pöyry, Rabinowitz, Rabinowitz, Roberge, Robles, Rondinini, Rondinini, Rondinini, Saetersdal, Sanderson, Sattler, Schooley, Sergio, Sergio, Simberloff, Thorne, Tobler, Torres, Wiens, Zeller, Zeller   +62 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Trans-Atlantic movements of Atlantic white-sided dolphins, Leucopleurus acutus

Frontiers in Marine Science
Atlantic white-sided dolphins are wide-ranging and abundant cetaceans of the North Atlantic, yet their movements remain poorly understood. Using satellite telemetry, we tracked 23 dolphins tagged in the Faroe Islands to investigate their movement ...
Sara De Clerck, Sara De Clerck, Hjálmar Hátún, Bjarni Mikkelsen, Fernando Ugarte, Ian Jonsen, Mads Peter Heide-Jørgensen   +6 more
doaj   +1 more source

The biopsychology of maternal behavior in nonhuman mammals [PDF]

, 1990
The term “maternal behavior,” when applied to nonhuman mammals, includes the behaviors exhibited in preparation for the arrival of newborn, in the care and protection of the newly arrived young, and in the weaning of those young, and represents a complex
Kristal, Dr. Mark B.
core  

Identification of a non-mammalian leptin-like gene:characterization and expression in the tiger salamander (Ambystoma tigrinum) [PDF]

, 2006
Leptin is well established as a multifunctional cytokine in mammals. However, little is known about the evolution of the leptin gene in other vertebrates. A recently published set of ESTs from the tiger salamander (Ambystoma tigrinum) contains a sequence
Boswell, Timothy, Burt, David W, Dunn, Ian C, Joseph, Nerine, Sharp, Peter J, Wilson, Peter W   +5 more
core   +1 more source