Results 81 to 90 of about 240,144 (264)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Ethnoherpetological notes regarding the paha frogs and conservation implication in Manaslu Conservation Area, Gorkha District, Nepal

Journal of Ethnobiology and Ethnomedicine, 2019
Background Paha hunting is a commonplace recreational activity in the mountainous regions of Nepal. The collection is primarily for food use and secondarily preferred as medicinal forms, and utilized by many ethnic groups: Magar, Rai, Gurung, Jirel, etc.
Biraj Shrestha, Min Bahadur Gurung
doaj   +1 more source

Miombo woodland termite mounds: resource islands for small vertebrates? [PDF]

, 2003
Macrotermes mounds are a significant feature of African woodland landscape, contributing to habitat heterogeneity. The mounds are massive, often many centuries old, and support dense vegetation and a suite of woody plant species scarce in surrounding ...
Fleming, P.A., Loveridge, J.P.
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Clinical Molecular Investigation of Encephalitozoon cuniculi in Pet Rabbits: Early Detection of Potential Risk for Animal and Human Infection

Veterinary Medicine and Science
Background Encephalitozoon cuniculi is an obligate intracellular parasite belonging to the phylum Microsporidia, family Encephalitozoonidae. The parasite is distributed worldwide and infects a variety of mammals, with rabbits being the main host ...
Maruša Škrbec, Brigita Slavec, Nina Kočar, Katarina Modrijan, Urška Kuhar, Marko Kolenc, Alenka Dovč, Olga Zorman Rojs, Jožko Račnik   +8 more
doaj   +1 more source

Electrochemotherapy with bleomycin of different types of cutaneous tumours in a ferret (Mustela putorius furo)

Radiology and Oncology, 2017
Mast cell tumour, sebaceous gland adenoma, and less common squamous papilloma are skin tumours in ferrets (Mustela putorius furo), and early excisional surgery is usually the treatment of choice.
Racnik Jozko, Svara Tanja, Zadravec Marko, Gombac Mitja, Cemazar Maja, Sersa Gregor, Tozon Natasa   +6 more
doaj   +1 more source

Tidal and seasonal influences in dolphin habitat use in a southern Brazilian estuary

Scientia Marina, 2017
In this study we describe how franciscana and Guiana dolphin habitat use is influenced by tidal cycles and seasonality in Babitonga Bay. The franciscanas use a greater area in winter and a smaller area in summer, but the extent of the area used did not ...
Renan Lopes Paitach, Paulo César Simões-Lopes, Marta Jussara Cremer   +2 more
doaj   +1 more source

Occurrence of Clostridium perfringens in Wild Mammals in the Amazon Biome

The objective of this study was to evaluate the occurrence of Clostridium perfringens in stool samples and swabs collected from wild mammals in the Amazon biome.
Hanna Gabriela da Silva Oliveira, Felipe Masiero Salvarani, Isabela Paduá Zanon, Sheyla Farhayldes Souza Domingues, Ananda Iara de Jesus Sousa, Rodrigo Otavio Silveira Silva, Cinthia Távora de Albuquerque Lopes   +6 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source