Results 61 to 70 of about 240,144 (264)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The mammals of Suriname

, 1978
(Uploaded by Plazi for the Bat Literature Project) No abstract provided.
openaire   +2 more sources

Circadian Corticosterone Profile in Laying Hens (Gallus gallus domesticus)

Animals
Measurement of blood corticosterone concentrations has been established as an indicator for assessment of acute distress. Therefore, knowledge on physiological fluctuations is required, but previous studies allow little conclusion on daily fluctuations ...
Theresa Hillebrecht, Rüdiger Korbel, Monika Rinder, Manfred Gahr   +3 more
doaj   +1 more source

) in Human Care

, 2005
Play-fighting is common in many mammals, especially among juveniles and subadults, providing a safe opportunity to practice behaviours important in adult life.
Christer Blomqvist, Mello, I.,, Blomqvist, Christer,, Inês Mello, Amundin, Mats,, Mats Amundin   +5 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Microbiological Assessment of Some Culturable Microbiotafrom Clinically Healthy Bottlenose Dolphins (Tursiops truncatus) Under Human Care

, 2016
The mammalian commensal microbiota constitutes over a thousand bacterial phylotypes (Suchodolski, 2014) and confers important functions, including a mucosal barrier function, a metabolic function, and an immune regulatory function, which contribute to ...
CASAGRANDE PROIETTI, Patrizia, Proietti, Patrizia Casagrande, Francesco Grande, Patrizia Casagrande Proietti, Grande, Francesco, MENCHETTI, LAURA, Gabriele Brecchia, BRECCHIA, Gabriele, Macrelli, Roberto, Letizia Fiorucci, Roberto Macrelli, Nespola, Filippo, Fiorucci, Letizia, Filippo Nespola, Laura Menchetti   +14 more
core   +2 more sources

Mammals and mammal-like robots

, 2018
Mammals are warm-blooded tetrapod vertebrates that evolved from reptilian ancestors during the late Triassic period around 225 million years ago. This chapter focuses on some of the most distinctive mammalian characteristics and on integrated robotic systems that seek to capture these capabilities in biomimetic artifacts.
openaire   +3 more sources

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source