Results 91 to 100 of about 55,565 (283)

The Presence of Aromatase mRNA and Protein in Ovine Mammary Fat Pad and Possible Effect of Birth Status on its Abundance [PDF]

, 2012
Aromatase is an enzyme that is important to concentrations of sex hormone in both developing and mature animals. It converts the male sex-hormone testosterone to estrogen, the female sex-hormone. One of the many functions of estrogen is to stimulate the
Watts, Jaimie
core  

Macrophages promote the progression of premalignant mammary lesions to invasive cancer. [PDF]

, 2017
Breast cancer initiation, progression and metastasis rely on a complex interplay between tumor cells and their surrounding microenvironment. Infiltrating immune cells, including macrophages, promote mammary tumor progression and metastasis; however, less
Anderson, Bissell, Blair, Colombatti, Colombo, Condeelis, Coussens, De Palma, Earp, Ghosh, Green, Gunaratne, Hermoso, Hylton, Jensen, Jirstrom, Lewis, Lidereau, Luo, Lydon, Maatta, Machado, Mantovani, Naber, Naldini, Ochiai, Ochoa, Piemonti, Pollard, Pollard, Pollard, Pollard, Pollard, Porse, Rosen, Rosen, Rosen, Sarukhan, Schwertfeger, Schwertfeger, Shen, Strassmann, Suthipintawong, Ullrich, Van Ginderachter, Van Ginderachter, van Rooijen, Visvader, Wang, West   +49 more
core   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Pregnancy Obstructs Involution Stage II of the Mammary Gland in Cows: General Biological Implications [PDF]

, 2007
*Background* Repeated research findings over the last 4 decades show that involution of mammary glands in dairy cows did not regress to same extend as that noticed in other mammalian species. *Methodology/Principal Findings ...
Ana-Maria Anug, Gabriel Leitner, Nissim Silanikove, Uzi Merin   +3 more
core   +1 more source

NK Cell Activation by Platinum Boosts Immunotherapy in HR+/HER2− Breast Cancer

Advanced Science, EarlyView.
Multi‐omics and single‐cell analyses identify activated NK cells as key mediators of anti‐PD‐(L)1 response in HR+/HER2− breast cancer. Platinum chemotherapy enhances NK cell cytotoxicity through NF‐κB–associated signaling, synergizing with immunotherapy and providing a rationale for combination treatment.
Yi‐Yu Chen, Yi‐Fan Zhou, Xuan Qi, Ya‐Xin Zhao, Tong Fu, Xi Jin, Minhong Shen, Yi‐Zhou Jiang, Zhi‐Ming Shao   +8 more
wiley   +1 more source

Localized and Systemic Inflammatory Mediators in a Murine Acute Mastitis Model

Journal of Inflammation Research, 2021
Miyuki Takashima,1,2 Christian Lalonde,1 Laura Ashley Olszanski,1 Feng-Qi Zhao1 1Department of Animal and Veterinary Sciences, University of Vermont, Burlington, VT, 05405, USA; 2Wakunaga Pharmaceutical Co. Ltd, Osaka, 532-0003, JapanCorrespondence: Feng-
Takashima M, Lalonde C, Olszanski LA, Zhao FQ   +3 more
doaj  

Survival analysis of female dogs with mammary tumors after mastectomy: epidemiological, clinical and morphological aspects

Pesquisa Veterinária Brasileira, 2016
: Mammary gland tumors are the most common type of tumors in bitches but research on survival time after diagnosis is scarce. The purpose of this study was to investigate the relationship between survival time after mastectomy and a number of clinical ...
Maria Luíza de M. Dias, Joanlise M. Leon Andrade, Márcio B. de Castro, Paula D. Galera   +3 more
doaj   +1 more source

Stem/progenitor cells in non-lactating versus lactating equine mammary gland [PDF]

, 2012
The mammary gland is a highly regenerative organ that can undergo multiple cycles of proliferation, lactation, and involution. Based on the facts that (i) mammary stem/progenitor cells (MaSC) are proposed to be the driving forces behind mammary growth ...
Burvenich, Christian, Bussche, Leen, Chiers, Koen, Spaas, Jan, Van de Walle, Gerlinde   +4 more
core   +2 more sources

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis

Frontiers in Immunology
Mastitis is a common inflammation of mammary glands that has a significantly impact on dairy production and animal health, causing considerable economic burdens worldwide.
Muhammad Zahoor Khan, Liangliang Li, Yandong Zhan, Huang Binjiang, Xiaotong Liu, Xiyan Kou, Adnan Khan, Abdul Qadeer, Qudrat Ullah, Khalid J. Alzahrani, Tongtong Wang, Changfa Wang, Muhammad Zahoor   +12 more
doaj   +1 more source