Results 81 to 90 of about 31,467 (302)

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source

Mammary gland of the rock cavy (Kerodon rupestris - Wied Neuwied, 1820): morphologic aspects

, 2008
Procurando colaborar com a exploração zootécnica racional dos mocós (Kerodon rupestrir) foi descrita a morfologia da glândula mamária destes roedores, que por sua vez podem tornar-se uma fonte de alimento para população nordestina. Foram utilizados cinco
Oliveira, Moacir Franco de, Lima, Marcelo Cardoso de, Miglino, Maria Angélica, Bonatelli, Mariana, Goiozo, Paulo Felipe Izique, Martins, Simone Maria Massami Kitamura, Carvalho, Ana Flávia de, Bonatelli, Marina   +7 more
core   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Localized and Systemic Inflammatory Mediators in a Murine Acute Mastitis Model

Journal of Inflammation Research, 2021
Miyuki Takashima,1,2 Christian Lalonde,1 Laura Ashley Olszanski,1 Feng-Qi Zhao1 1Department of Animal and Veterinary Sciences, University of Vermont, Burlington, VT, 05405, USA; 2Wakunaga Pharmaceutical Co. Ltd, Osaka, 532-0003, JapanCorrespondence: Feng-
Takashima M, Lalonde C, Olszanski LA, Zhao FQ   +3 more
doaj  

CeRNA Network Reveals the Circular RNA Characterization in Goat Ear Fibroblasts Reprogramming into Mammary Epithelial Cells

, 2023
Circular RNAs (circRNAs) are a type of non-coding RNA that play a crucial role in the development and lactation of mammary glands in mammals. A total of 107 differentially expressed circRNAs (DE circRNAs) were found, of which 52 were up-regulated and 55 ...
Liangshan Qin, Jam Zaheer Ahmed Sahito, Shan Deng, Ben Huang, Lianggui Xiao, Dandan Zhang   +5 more
core   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis

Frontiers in Immunology
Mastitis is a common inflammation of mammary glands that has a significantly impact on dairy production and animal health, causing considerable economic burdens worldwide.
Muhammad Zahoor Khan, Liangliang Li, Yandong Zhan, Huang Binjiang, Xiaotong Liu, Xiyan Kou, Adnan Khan, Abdul Qadeer, Qudrat Ullah, Khalid J. Alzahrani, Tongtong Wang, Changfa Wang, Muhammad Zahoor   +12 more
doaj   +1 more source

Survival analysis of female dogs with mammary tumors after mastectomy: epidemiological, clinical and morphological aspects

Pesquisa Veterinária Brasileira, 2016
: Mammary gland tumors are the most common type of tumors in bitches but research on survival time after diagnosis is scarce. The purpose of this study was to investigate the relationship between survival time after mastectomy and a number of clinical ...
Maria Luíza de M. Dias, Joanlise M. Leon Andrade, Márcio B. de Castro, Paula D. Galera   +3 more
doaj   +1 more source

Effects of Dietary Supplementation of Lauric Acid on Lactation Function, Mammary Gland Development, and Serum Lipid Metabolites in Lactating Mice

, 2020
Our previous studies demonstrated that lauric acid (LA) stimulated mammary gland development during puberty. However, the roles of LA on lactation in mice remain indeterminate.
Qiang Yang, Wuzhou Yi, Fan Li, Fangfang Liu, Songbo Wang, Lin Yang, Qingyan Jiang   +6 more
core   +1 more source