Results 71 to 80 of about 31,467 (302)

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang, Ning Lu, Zhuo Yan, Luyi Ye, Luyao Bai, Shanshan Yuan, Yuting Zhu, Yiru Xiong, Yongheng Bai, Yaping Chen, Junjie Deng   +10 more
wiley   +1 more source

Mammary hyperplasia in a pregnant queen

, 2008
Mammary hyperplasia producing severe swelling and ulceration of the mammary glands occurred during late gestation in a 10-month-old queen. Inguinal and caudal abdominal mammary glands and the left cranial abdominal mammary gland were asymmetrically and ...
Seyrek-İntas, Kamil, Şimşek, Gözde, Keskin, Abdulkadir, Yılmazbaş, Gülnaz   +3 more
core   +1 more source

Lighting up Macrophage Reprogramming Assists Immunosuppressive Niche Modulation in Primary Tumors and Tumor‐Draining Lymph Nodes of Breast Cancer

Advanced Science, EarlyView.
This study develops an intelligent NIR‐II‐responsive nanoplatform to combat immunosuppression in breast cancer. It enables real‐time visualization of macrophage activity via “off‐on” fluorescence while simultaneously reprogramming macrophages through the CSF‐1R and CD47‐SIRPα pathways.
Yingbo Li, Di Chang, Jie Yang, Ying Bai, Min Chen, Daoshuang Li, Zuoyu Xu, Jiaxin Yuan, Xiaoxuan Xu, Zhiqi Zhang, Yize Li, Zixin Chen, Jinbing Xie, Zebin Xiao, Shenghong Ju   +14 more
wiley   +1 more source

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

Histological Features in the Mammary Glands of Female Dogs throughout Lactation

, 2010
> The objective of this study was to describe the histology of the mammary glands of female dogs throughout lactation. Twelve lactating female dogs were operated 4, 7, 10, 14, 21, 28, 35, 42, 56, 70 and 84 days post-partum; four mammary glands of each ...
Mavrogianni, V. S., C. M. Boscos, I. A. Taitzoglou, Pourlis, A., Taitzoglou, I. A., Orfanou, D. C., Ververidis, H. N., G. C. Fthenakis, D. C. Orfanou, Fthenakis, G. C., Boscos, C. M., H. N. Ververidis, V. S. Mavrogianni, A. Pourlis   +13 more
core   +1 more source

Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy

Advanced Science, EarlyView.
ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang, Ming Qin, Wenjing Lai, Shiwen Chen, Fengling Wang, Dandan Xie, Maohua Chen, Changpeng Hu, Kui Wang, Rong Zhang, Guobing Li   +10 more
wiley   +1 more source

Changes in the concentrations.of the minor Constituents of goat's milk during starvation and on refeeding of the lactating animal and their relationship to mammary gland metabolism [PDF]

British Journal of Nutrition, 1981
1. Changes in the concentrations of the minor constituents of goat's milk were observed during 48 h starvation and on refeeding.2. The concentrations of hexose phosphate and UDP-hexoses increased during starvation and decreased on refeeding.3. The concentrations of phosphoenolpyruvate and glycerate 3-phosphate decreased during starvation and increased ...
N, Chaiyabutr, A, Faulkner, M, Peaker
openaire   +2 more sources

Total submandibular sialoadenectomy on the histopathological features of non-lactating mammary glands in sexually mature rats

, 2021
The influence of the submandibular salivary glands on the morphology of the non-lactating mammary gland in rat was examined by determining the effect of total surgical removal of the submandibular salivary gland (total submandibular sialoadenectomy) on ...
Palma, Roanna Zerla E., De Ocampo, Grace D., Bariuan, Jussiaea V., Sacnahon, Grace R., Estacio, Maria Amelita C.   +4 more
core  

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Comparative characteristics of mammary glands cancer in humans and animals

Саратовский научно-медицинский журнал, 2012
<p>&nbsp;</p><p>This review is devoted to a comparative analysis of receptor status, immunity, angiogenesis, metastatic mammal glands cancer expression profiling in humans and animals. Angiogenesis has been assessed by quantitative and immunohistochemical characteristics by means of evaluation of microvascular density (MVD) using ...
Vorobyova О.V., Terentyuk G.S., Bucharskaya A.B.   +2 more
openaire   +1 more source