Results 231 to 240 of about 31,467 (302)

Rumen-Plasma-Milk Metabolomics Profiling Revealed Metabolic Alterations Associated with Milk Fat Synthesis in Chinese Holstein Cows. [PDF]

Animals (Basel)
Zhang H, Kollie SC, Xia T, Yang Z, Ian MT, Elolimy AA, Wang W, Lu D, Li Y, Li M, Loor JJ, Mao Y, Yang Z.   +12 more
europepmc   +1 more source

Nonclinical Considerations for Support of Pregnancy and Lactation in Clinical Trials

Birth Defects Research, Volume 118, Issue 6, June 2026.
ABSTRACT Background Pregnant and breastfeeding individuals remain underrepresented in clinical drug development, leaving health care providers and patients with limited data to inform treatment decisions. Current practice relies heavily on nonclinical developmental and reproductive toxicity (DART) studies in animals, while clinical trials typically ...
Dinesh Stanislaus, Christopher J. Bowman, Kimberly C. Brannen, Sarah N. Campion, Laura M. Carlson, Stephan Chalon, Anthony M. DeLise, Claudia Demarta‐Gatsi, Brian P. Enright, Wendy Halpern, Shermaine Mitchell‐Ryan, Vicki Sutherland, Karen Thacker, Kary Thompson, Belen Tornesi, Steven Van Cruchten, Ronald L. Wange, Tacey White, Connie L. Chen   +18 more
wiley   +1 more source

Integrated Transcriptomic Analysis Identifies Core Hub Genes Regulating Mammary Gland Traits (Milk Quality/Lactation) in Dairy Livestock: <i>Bos taurus</i> and <i>Ovis aries</i>. [PDF]

Genes (Basel)
Zhang Q, Yang L, Li Y, Gu P, Si R, Li S, Zhu L, Zhang W.   +7 more
europepmc   +1 more source

Cardiovascular β‐Adrenergic Receptor Distribution and Function: Influence of Species, Sex, Age, and Tissue

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Estrogen modulates β‐AR signaling in a context‐dependent manner influenced by species, sex, age, tissue, and vascular health, highlighting challenges in translating findings from experimental models to human cardiovascular physiology. ABSTRACT Cardiovascular diseases remain the leading global cause of morbidity and mortality, with notable sex‐specific ...
Basant Elsaid, Irakli Kopaliani, Birgit Zatschler, Ansam Seif, Stephan Speier, Andreas Deussen   +5 more
wiley   +1 more source

Induction of senescence during postpartum mammary gland involution supports tissue remodeling and promotes postpartum tumorigenesis. [PDF]

Nat Aging
Chiche A, Djoual L, Charifou E, Wang S, Temime L, Saclier M, Wang S, Chantrel J, Li H.   +8 more
europepmc   +1 more source

Standardized Pipeline for Metabolism and Cognition in GO‐DS21 Mouse Model: Investigating Down Syndrome Comorbidities

Current Protocols, Volume 6, Issue 6, June 2026.
Abstract Down syndrome (DS) is the most prevalent form of intellectual disability (ID) globally, with an incidence rate of approximately 1 in 1000 births, affecting over 5 million individuals worldwide. DS is characterized by a genetic profile that predisposes individuals to a range of medical and cognitive conditions, including ID and obesity, which ...
Mohammed Selloum, Patricia da Silva‐Buttkus, Fabrice Riet, Nathalia R. V. Dragano, Lillian Garrett, Hugues Jacobs, Sabine M. Hölter, Nicolas Torquet, Birgit Rathkolb, Loic Lindner, Valerie Gailus‐Durner, Guillaume Pavlovic, Li Chan, Johannes Beckers, Benoit Petit Demoulière, Helmut Fuchs, Elodie Ey, Tania Sorg, Martin Hrabe de Angelis, Yann Herault, the GO‐DS21 Consortium   +20 more
wiley   +1 more source

Overexpression of mitofusin 2 ameliorates inflammation and oxidative stress in lipopolysaccharide-induced mastitis model by regulating phosphofurin acidic cluster sorting protein 2. [PDF]

Animal Model Exp Med
Zhou X, Zhang Y, Ma H, Fu S, Liu J, Guo W, Tian X, Huang B.   +7 more
europepmc   +1 more source

Assessment of Doxorubicin Internalization and Cytotoxicity in Primary Tumor Spheroids After Collagen Digestion

Current Protocols, Volume 6, Issue 6, June 2026.
Abstract The limited penetration of chemotherapeutic agents into solid tumors remains a major obstacle to effective cancer treatment and is strongly influenced by the extracellular matrix (ECM). Three‐dimensional (3D) tumor spheroids derived from primary tumor cells (PTCs) represent a valuable in vitro model to study how ECM composition and ...
Alessandra Lo Cicero, Gabriele Lo Buglio, Simona Campora, Giulio Ghersi   +3 more
wiley   +1 more source

Single‐cell profiling reveals peripheral blood immune landscape remodelling in breast cancer lymph node metastasis

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
scRNA‐seq reveals pro‐metastatic neutrophil and exhausted T/NK subsets in BC patients with LN metastasis. Interferon‐stimulated neutrophils secrete LGALS9, drives T/NK cell exhaustion via HAVCR2. Neutralising LGALS9 restores T‐cell anti‐tumour activity, suggesting a novel therapeutic target.
Bo Chen, Kang Ma, Yunjie Wang, Liulu Zhang, Xinyue Feng, Cheng Long, Xuejing Tan, Kun Wang   +7 more
wiley   +1 more source

Microbe-associated molecular patterns differentially mediate carcinogenic alterations of the breast tissue in the context of obesity. [PDF]

Neoplasia
Gaber M, Moulden LM, Wilson AS, Payne V, Holmes J, Neary K, Peoples A, Duet ML, Katz AJ, Vidi PA, Cook KL.   +10 more
europepmc   +1 more source