Results 101 to 110 of about 71,975 (282)
The MPA mouse breast cancer model: evidence for a role of progesterone receptors in breast cancer [PDF]
, 2009 More than 60% of all breast neoplasias are ductal carcinomas expressing estrogen (ER) and progesterone receptors (PR). In contrast, most of the spontaneous, chemically or MMTV induced tumors, as well as tumors arising in genetically modified mice do not ...
Bottino, Maria Cecilia +9 more
core +1 more source
DEVELOPMENT OF HUMAN MAMMARY GLAND - A PRENATAL STUDY.
Journal of Evolution of medical and Dental Sciences, 2012 fetuses of varying gestational ages, ranging from 33m.m C.R.L. to 270m.m.C.R.L. (i.e. from 8weeks to 32weeks of intrauterine life) were studied to note the developmental sequence of mammary gland. Tissues were prepared for microtomy by Paraffin wax embedding method.
Rachna Magotra +2 more
openaire +1 more source
BMC Cancer, 2007 Background Feline mammary carcinoma has been proposed as a natural model of highly aggressive, hormone-independent human breast cancer. To further explore the utility of the model by adding new similarities between the two diseases, we have analyzed the ...
Martín de las Mulas Juana +4 more
doaj +1 more source
NK Cell Activation by Platinum Boosts Immunotherapy in HR+/HER2− Breast Cancer
Advanced Science, EarlyView.Multi‐omics and single‐cell analyses identify activated NK cells as key mediators of anti‐PD‐(L)1 response in HR+/HER2− breast cancer. Platinum chemotherapy enhances NK cell cytotoxicity through NF‐κB–associated signaling, synergizing with immunotherapy and providing a rationale for combination treatment.
Yi‐Yu Chen +8 more
wiley +1 more source
Distinct expression patterns of ER alpha and ER beta in normal human mammary gland [PDF]
, 2002 AIM: Two oestrogen receptors (ERs) have been identified to date—the “classic” ERa and the more recently described ERb. Although much is known about ERa at the mRNA and protein levels, our knowledge of the expression and distribution of ERb protein is ...
Burdall, S.E. +3 more
core
Breast Cancer Research, 2019 Background Prophylactic mastectomy is the most effective intervention to prevent breast cancer. However, this major surgery has life-changing consequences at the physical, emotional, psychological, and social levels. Therefore, only high-risk individuals
Elizabeth Kenyon +13 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang +9 more
wiley +1 more source
Diet-induced obesity impairs mammary development and lactogenesis in murine mammary gland [PDF]
, 2005 We have developed a mouse model of diet-induced obesity that shows numerous abnormalities relating to mammary gland function. Animals ate 40% more calories when offered a high-fat diet and gained weight at three times the rate of controls. They exhibited
Barber, Michael C. +4 more
core +1 more source
Advanced Science, EarlyView.ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao +12 more
wiley +1 more source
One HealthQuantification of trace element concentrations in human and animal tissues has acquired great importance in the last few years, considering the pivotal role of these elements in several physiological and pathological processes.
Sabrina V.P. Defourny +11 more
doaj +1 more source