Results 101 to 110 of about 42,440 (264)

A Droplet‐Microarray Platform for Multiplex Profiling of Breast Cancer Exosome Subtypes in Patients’ Blood Plasma Samples

Small, EarlyView.
This study presents a droplet‐microarray platform integrated with a DNase I‐assisted MoS2 FRET aptasensor for multiplexed profiling of breast cancer subtypes’ exosomes from patients’ plasma. By targeting HER2, MUC1, and CD44, the system enables sensitive detection and accurate discrimination of luminal A, HER2‐positive, and triple‐negative subtypes ...
Yi Liu, Ruolin Zhang, Jialei Song, Meng Xiao, Yue Meng, Zhiyang Li, Jingyu Shi, Yunyan Tai, Bing Gu, Mo Yang   +9 more
wiley   +1 more source

Construction and Identification of a Breast Bioreactor for Human-Derived Hypoglycemic Protein Amylin

Life
The mammary gland of mammals can generate numerous bioactive proteins. To express the human amylin protein in the mammary glands of domestic animals, we engineered a transgenic mammary gland bioreactor. For this study, we produced transgenic mice through
Kongwei Huang, Xiuying Yan, Zhipeng Li, Fuhang Liu, Kuiqing Cui, Qingyou Liu   +5 more
doaj   +1 more source

Stress‐Adaptive Biomaterials With Tunable Yielding Architectures Regulate Organoid Morphogenesis

Small, EarlyView.
Granular hydrogels are developed to tune the yield stress levels at which 3D tissue culture matrices undergo plastic deformation. We use these materials to regulate growth‐induced stresses, with demonstrable effects on cancer spheroid invasion and brain organoid morphogenesis.
James P. W. Reeves, Sabra Rostami, Mostafa Rammal, Andrei Bocan, Paula Lépine, Matthew J. Harrington, Thomas M. Durcan, Christopher Moraes   +7 more
wiley   +1 more source

In Vitro Studies of the Normal Human Mammary Gland

Journal of Investigative Dermatology, 1974
In vitro techniques can be used to analyze human mammary gland physiology. In organ culture, human breast tissue survived intact for up to 16 days in defined medium without supplemental serum or hormones. The alveolar epithelial cells showed a significant level of DNA synthesis and mitosis which could be further augmented by insulin or prolactin ...
openaire   +1 more source

Theranostic π Electron‐Stabilized Polymeric Micelles for PET Imaging‐Guided Drug Delivery to Tumors

Small, EarlyView.
Cancer nanomedicine efficacy is limited by heterogeneous nanoparticle accumulation in tumors. Nuclear imaging offers non‐invasive, patient‐ and lesion‐specific visualization and quantification of nanoparticle uptake. We present a positron emission tomography (PET)‐imageable micelle platform for direct quantification of nanoparticle accumulation and ...
Alec Wang, Alexandru Florea, Jan‐Niklas May, Zaheer Ahmed, Karolin Roemhild, Thomas Hansen, Rahaf Mihyar, Armin Azadkhah Shalmani, Laura Schäfer, Karolin Becker, Masoud Sadeghzadeh, Eva M. Buhl, Sven Thoröe‐Boveleth, Susanne Lütje, Agnieszka Morgenroth, Fabian Kiessling, Jochen Maurer, Josbert M. Metselaar, Yang Shi, Felix M. Mottaghy, Quim Peña, Twan Lammers   +21 more
wiley   +1 more source

Two‐Photon Endomicroscopy for Image‐Guided Magnetic Micro‐Agents

Small, EarlyView.
Image‐guided manipulation of magnetic micro‐agents requires localized fluorescence feedback capable of resolving dynamic interactions in confined environments. This study introduces a two‐photon endomicroscopy platform for real‐time motion tracking, multicolor micro‐agent discrimination, and imaging through biological tissue.
Juan J. Huaroto, Gert‐willem Römer, Ivo M. Vellekoop, Sarthak Misra   +3 more
wiley   +1 more source

Thrombocytosis and tumour distribution predict outcome in dogs with hepatocellular carcinoma: A multi‐institutional retrospective analysis

Veterinary Record, EarlyView.
Abstract Background Hepatocellular carcinoma (HCC) is the most common canine hepatobiliary tumour. This study aimed to determine which criteria influenced outcome of HCC in a modern population of dogs across eight institutions. Methods The medical records of 106 dogs with HCC were retrospectively reviewed.
Emily A. Janik, MacKenzie A. Pellin, Dawn M. Clarke   +2 more
wiley   +1 more source

Quantification of steroid hormones in free‐ranging Apennine wolf Canis lupus italicus hair samples collected post‐mortem

Wildlife Biology, EarlyView.
After decades of dramatic reductions in their populations, Italian wolves have begun recolonizing parts of their historic range. This growth in populations can lead to potential conflicts with human activities, which remain the main cause of wolf mortality.
Ilaria Troisio, Carmela Musto, Nicola Acquisti Casi, Nadia Govoni, Giuseppe Merialdi, Domenico Ventrella, Alberto Elmi, Mauro Delogu, Maria Laura Bacci   +8 more
wiley   +1 more source

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source