Results 191 to 200 of about 218,839 (237)

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science, Volume 13, Issue 1, 5 January 2026.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
wiley   +1 more source

Innovative Chorioallantoic Membrane Model as Valuable Tool in Diagnostics and Testing of Domestic Animal Cancers. [PDF]

Transbound Emerg Dis
Sczasny A, Gubernator J, Jaromin A, Chen N.   +3 more
europepmc   +1 more source

Integrin‐Piezo1 Axis Drives ECM Remodeling and Invasion of 3D Breast Epithelium

Advanced Science, Volume 13, Issue 5, 27 January 2026.
Mechanical stiffening of the extracellular matrix around mature mammary acini induces sequential remodeling phases. An early response disrupts the basement membrane and promotes fibronectin secretion, followed by delayed invasion with matrix reorganization and proliferation.
Kabilan Sakthivel, Anna Kotowska, Zhimeng Fan, Ellen Juel Portner, Catherine Merry, Pontus Nordenfelt, Adam Cohen Simonsen, Amanda J. Wright, Vinay S Swaminathan   +8 more
wiley   +1 more source

Brillouin Microscopy of Breast tumor Spheroids On‐a‐Chip: Mechanical and Transcriptional Responses to Microfluidic‐Induced Rapid Deformations

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Brillouin‐Raman Microspectroscopy on‐a‐Chip (BRmS) enables real‐time analysis of breast tumor spheroids in microfluidic channels. Following cyclical deformations, MCF10.DCIS.com spheroids are captured in recovery traps and imaged with BRmS. The applied deformations trigger a stiffening response marked by increased frequency shifts, elevation of the ...
Mona Makkieh, Alessandra Anna Passeri, Davide Lazzari, Stefano Marchesi, Andrea Disanza, Rafal Khaled Ahmad Salem, Francesco Bonacci, Camillo Mazzella, Emanuele Martini, Mattia Tonani, Leonardo Donati, Edoardo Bellini, Hind Abdo, Judith Pineau, Serena Magni, Fabrizio Orsenigo, Matthieu Piel, Daniele Fioretto, Sabata Martino, Maurizio Mattarelli, Giorgio Scita, Brenda J. Green, Silvia Caponi   +22 more
wiley   +1 more source

Improvement of DCIS resection using intraoperative imaging with ICG-p28. [PDF]

Sci Rep
Mander S, Goto M, Christov K, Green A, Gupta TKD, Yamada T.   +5 more
europepmc   +1 more source

Flash Photodynamic Therapy – How the Saturation of Photosensitizer Absorption Enables Selective and Deeper Tumor Treatments

Advanced Science, Volume 13, Issue 1, 5 January 2026.
FLASH‐PDT uses strongly‐absorbing photosensitizers and pulsed lasers to saturate the photosensitizer absorption at ≈1‐cm tissue depths. This allows for the generation of [ROS] above the necrosis threshold level for tumors, while maintaining [ROS] in peritumoral tissues below that threshold, even when the tumor‐to‐peritumoral tissue ratio is as low as 2.
Luis G. Arnaut, Fábio A. Schaberle, José Sereno, Lígia C. Gomes‐da‐Silva   +3 more
wiley   +1 more source

Metronomic Chemotherapy in Dogs and Cats: Mechanisms, Indications, and Clinical Perspectives. [PDF]

Cancers (Basel)
Bitencourt RC, Cruvinel GG, Terrabuio VMTC, Linhares LCM, Bispo GA, Anai LA, Sobreira MFDR, Camplesi AC, De Nardi AB, Santana AE.   +9 more
europepmc   +1 more source

NUSAP1 Recruits DAXX to Suppress HIF‐Driven Triple‐Negative Breast Cancer Progression

Advanced Science, Volume 13, Issue 5, 27 January 2026.
A double‐negative feedback loop is identified in TNBC where NUSAP1 bridges HIF and DAXX via its microtubule‐associated domain (MAD) to recruit SETDB1, repressing HIF transcriptional activity by depositing the H3K9me3 repressive mark on HIF target genes, while HIF itself suppresses NUSAP1.
Yating Du, Jingjing Wang, Min Wang, Yao Zhang, Miaomiao Zheng, Huiyan Li, Xuemeng Wang, Huanran Sun, Kexin Tang, Changliang Shan, Qiang Zhao, Xiaoqian Meng, Yijie Wang, Jun Zhou, Yan Chen   +14 more
wiley   +1 more source

Effect of Nanoemulsions of Betulinic Acid on the Development of Canine Mammary Tumors. [PDF]

Vet Sci
Amoros-Cerón ZY, Pinos-Rodríguez JM, García HS, Olivares-Muñoz A, De Gasperin-López I, Flores-Primo A.   +5 more
europepmc   +1 more source

Cancer Manipulates Adjacent Adipose Tissue to Exploit Fatty Acids via HIF‐1α/CCL2/PPARα Axis: A Metabolic Circuit to Support Tumor Progression

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Cancer cells drive adjacent adipose tissue to release fatty acids by secreting CCL2, which activates PPARα‐dependent lipolysis. The resulting fatty acid influx amplifies HIF‐1α/CCL2 signaling, establishing a positive feedback loop that fuels tumor growth.
Jeong‐Eun Yun, Jieun Seo, Jiwon Koh, Seock‐Ah Im, Ki Yong Hong, Yeseon Son, Do‐Won Jeong, Junji Fukuda, Jong‐Wan Park, Yang‐Sook Chun   +9 more
wiley   +1 more source