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Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

Spheroid Model of Mammary Tumor Cells: Epithelial-Mesenchymal Transition and Doxorubicin Response. [PDF]

Biology (Basel)
Coelho LL, Vianna MM, da Silva DM, Gonzaga BMS, Ferreira RR, Monteiro AC, Bonomo AC, Manso PPA, de Carvalho MA, Vargas FR, Garzoni LR.   +10 more
europepmc   +1 more source

Autophagy is required for mammary tumor recurrence by promoting dormant tumor cell survival following therapy. [PDF]

Breast Cancer Res
Dwyer S, Ruth J, Seidel HE, Raz AA, Chodosh LA.   +4 more
europepmc   +1 more source

Salinomycin induces apoptosis and potentiates the antitumor effect of doxorubicin against feline mammary tumor 2.5D organoids. [PDF]

J Vet Med Sci
Liu Y, Elbadawy M, Yamamoto H, Augomaa A, Ishihara Y, Kaneda M, Usui T, Sasaki K.   +7 more
europepmc   +1 more source

Transgenic overexpression of the miR-200b/200a/429 cluster prevents mammary tumor initiation in Neu/Erbb2 transgenic mice. [PDF]

Int J Cancer
Watson KL, Moorehead RA.
europepmc   +1 more source

Dysregulated Signaling Pathways in Canine Mammary Tumor and Human Triple Negative Breast Cancer: Advances and Potential Therapeutic Targets. [PDF]

Int J Mol Sci
Mei C, Liu Y, Liu Z, Zhi Y, Jiang Z, Lyu X, Wang H.   +6 more
europepmc   +1 more source

USP11 deubiquitinates E-cadherin and maintains the luminal fate of mammary tumor cells to suppress breast cancer. [PDF]

J Biol Chem
Qian T, Bai F, Zhang S, Xu Y, Wang Y, Yuan S, Liu X, Du Y, Peng B, Zhu WG, Xu X, Pei XH.   +11 more
europepmc   +1 more source

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The Mammary Tumor Microenvironment

2020
A developing breast tumor is regulated by its tumor microenvironment (TME) which includes various immune cell subsets, fibroblasts, adipocytes, and endothelial and epithelial cells surrounded by an extracellular matrix (ECM). Breast tissue density is also a defining feature of breast cancer and plays an integral role in the exchange of biochemical cues
Colleen S, Curran, Suzanne M, Ponik
openaire   +2 more sources

Feline Mammary Tumors

Veterinary Clinics of North America: Small Animal Practice, 1985
The characteristics of feline mammary cancer--that is, the rapid growth of primary mammary tumors, the high rate of tumor recurrence, and the poor survival statistics--demonstrate the need for (1) early diagnosis of the primary tumor; (2) immediate, aggressive surgical therapy; and (3) frequent follow-up examinations to detect early clinical signs of ...
A A, Hayes, S, Mooney
openaire   +2 more sources

Mammary Tumor Viruses

1979
Two hundred years ago, Bernard Peyrilhe of Perpignan, France, believing that cancer might be caused by “a specific virus,”* injected subcutaneously, into a dog, fluid from a human breast carcinoma. This was 25 years before Edward Jenner inoculated an 8-year-old boy with “matter from cow-pox vesicles” which successfully protected him against a later ...
D H, Moore, C A, Long, A B, Vaidya, J B, Sheffield, A S, Dion, E Y, Lasfargues   +5 more
openaire   +2 more sources