Results 41 to 50 of about 1,873,134 (303)

Identification of prognostic collagen signatures and potential therapeutic stromal targets in canine mammary gland carcinoma. [PDF]

PLoS ONE, 2017
Increasing evidence indicates that the tumor microenvironment plays a critical role in regulating the biologic behavior of breast cancer. In veterinary oncology, there is a need for improved prognostic markers to accurately identify dogs at risk for ...
Ashley Case, Becky K Brisson, Amy C Durham, Suzanne Rosen, James Monslow, Elizabeth Buza, Pascale Salah, Julie Gillem, Gordon Ruthel, Sridhar Veluvolu, Veronica Kristiansen, Ellen Puré, Dorothy C Brown, Karin U Sørenmo, Susan W Volk   +14 more
doaj   +1 more source

Serum PD-1/PD-L1 Levels, Tumor Expression and PD-L1 Somatic Mutations in HER2-Positive and Triple Negative Normal-Like Feline Mammary Carcinoma Subtypes

, 2020
Tumor microenvironment has gained great relevance due to its ability to regulate distinct checkpoints mediators, orchestrating tumor progression. Serum programmed cell death protein-1 (PD-1) and programmed death ligand-1 (PD-L1) levels were compared with
Catarina Nascimento, Nascimento, Catarina, Fernando Ferreira, Ana Catarina Urbano, Gameiro, Andreia, Ferreira, João, Ferreira, Fernando, Correia, Jorge Manuel de Jesus, Jorge Correia, Andreia Gameiro, João Ferreira, Urbano, Ana Catarina   +11 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Amplification of mouse mammary tumor virus genomes in non-mammary tumor cells [PDF]

Journal of Virology, 1989
Extra proviral copies of mouse mammary tumor virus (MMTV) are known to be present in the genomes of certain T-cell lymphomas of mice. Analysis of additional non-mammary tumor cell types known to express MMTV transcripts and antigens revealed the presence of extra acquired MMTV proviruses in a pituitary tumor cell line, a macrophage line, and Leydig ...
J, Racevskis, H, Beyer
openaire   +2 more sources

Mouse Mammary Tumor Virus Molecular Biology and Oncogenesis

Viruses, 2010
Mouse mammary tumor virus (MMTV), which was discovered as a milk‑transmitted, infectious cancer-inducing agent in the 1930s, has been used since that time as an animal model for the study of human breast cancer.
Susan R. Ross
doaj   +1 more source

Supplementary Data from Tumor necrosis factor deficiency inhibits mammary tumorigenesis and a tumor necrosis factor neutralizing antibody decreases mammary tumor growth in neu/erbB2 transgenic mice

, 2009
Supplementary Data from Tumor necrosis factor deficiency inhibits mammary tumorigenesis and a tumor necrosis factor neutralizing antibody decreases mammary tumor growth in neu/erbB2 transgenic ...
David J. Shealy (15042377), Suzanne F. Shoemaker (15042374), Margot M. Ip (15042380), Mary Ann Warren (15042371), Wiam Bshara (318111)   +4 more
core   +1 more source

RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness [PDF]

, 2021
Rank signaling enhances stemness in mouse and human mammary epithelial cells (MECs) and mediates mammary tumor initiation. Mammary tumors initiated by oncogenes or carcinogen exposure display high levels of Rank and Rank pathway inhibitors have emerged ...
Sanz-Moreno, Adrián, Benitez, S., Redondo-Pedraza, J., Palmero, Ignacio, Santamaría, Patricia G., Collado-Solé, Alejandro, Troulé, K., Da Silva-Álvarez, Sabela, Alcazar, Noelia, González Suárez, Eva, Santos, J.C., Gómez-Aleza, Clara, Serrano, Manuel, Gómez-López, Gonzalo, Silva-Alvarez, S. da, Yoldi, Guillermo, Collado-Solé, A., Gómez-López, G., Collado, M., Yoldi, G., De Benedictis, Ilaria, Serrano Marugán, Manuel, Gómez López, Gonzalo, Jimenez, M., Gonzalez-Suarez, E., Collado, Manuel, Palmero, I., Sanz Moreno, Adrian, De Benedictis, I., Cordero, A., Alcazar, N., Santos, Juliana C., Benedictis, Ilaria De, Gómez-Aleza, C., Serrano, M., Rocha, A.S., Santamaria, P.G., Redondo-Pedraza, Jaime, Rocha, Ana S., Silva Álvarez, Sabela Da, Troulé, Kevin, Sanz-Moreno, A., Da Silva-Álvarez, S., Benítez, Sandra, González-Suarez, Eva, Cordero, Alex, Redondo Pedraza, Jaime, Gómez Aleza, Clara, Jimenez, María, Ignacio Palmero, Sandra Benítez, Ana S. Rocha, Manuel Serrano, Sabela Da Silva-Álvarez, Kevin Troulé, Alejandro Collado-Solé, Jaime Redondo-Pedraza, Clara Gómez-Aleza, Eva Gonzalez-Suarez, Manuel Collado, Alex Cordero, Juliana C. Santos, Noelia Alcazar, Gonzalo Gómez-López, Maria Jimenez, Adrian Sanz-Moreno, Patricia G. Santamaría, Guillermo Yoldi, Ilaria De Benedictis   +68 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Detection of mutations within exons 4 to 8 of the p53 tumor suppressor gene in canine mammary glands

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2012
Fifteen female canines with mammary tumors and 6 normal females were used to study mutations in exons 4 to 8 of the p53 gene. DNA samples from the tumors, respective adjacent normal mammary tissue and mammary glands from healthy animals were sequenced ...
D.M.B. Souza, M.G.O. Barros, J.S.C. Silva, M.B. Silva, Z.F. Coleto, G.C. Jimenez, M. Adrião, A. Wischral   +7 more
doaj   +1 more source

Murine amniotic fluid stem cells contribute mesenchymal but not epithelial components to reconstituted mammary ducts [PDF]

, 2010
Introduction: Amniotic fluid harbors cells indicative of all three germ layers, and pluripotent fetal amniotic fluid stem cells (AFSs) are considered potentially valuable for applications in cellular therapy and tissue engineering.
Bernd Groner, Vafaizadeh, Vida, Groner, Bernd, Petra AB Klemmt, Vida Vafaizadeh, Klemmt, Petra A. B.   +5 more
core   +1 more source