Results 61 to 70 of about 137,047 (303)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Kay Boyle and Mary Reynolds: Friendship Intensified by War
E-REA, 2013 In this article, I explore the friendship that existed between Kay Boyle and Mary Reynolds, primarily during World War II. For both of them, their engagement in the war, Boyle as an anti-Fascist fiction writer, and Reynolds as a participant in the French
Page DOUGHERTY DELANO
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Sahel Medical Journal, 2013 Acute amiodarone pulmonary toxicity is a rare cause of acute respiratory distress in intensive care units. A 52-year-old man developed acute respiratory distress following intravenous amiodarone administration for refractory ventricular tachycardia.
Vijayakumar Subban +3 more
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
May Ray as an Artist and Photographer: Problems of Self-identification
Известия Уральского федерального университета. Серия 2: Гуманитарные науки, 2018 This article considers the problems of self-identification by Man Ray (1890–1976) as a painter and photographer in the first half of the 20th century, the era of formation of a new aesthetic paradigm that included the de-mythologisation of the artist and
Оlga Nikolayevna Averyanova
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