Results 61 to 70 of about 19,556,464 (342)

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte   +10 more
wiley   +1 more source

Seek Guidance for Complex Practice Challenges: Ethics, Financial Protection and Employee Relations

open access: yesJournal of the California Dental Association, 2023
TDIC Risk Management Staff
doaj   +1 more source

Work-Life Balance and Job Performance: A Mediating and Moderating Model

open access: yesMarket Forces, 2022
Work-life balance has become a critical issue in the service sector, especially in the banks. Given its importance, we have developed a model with four direct and two indirect hypotheses. We developed a questionnaire based on the past studies, containing
Asima Faisal   +2 more
doaj  

Improving water productivity: how do we get more crop from every drop [PDF]

open access: yes
Water management / Productivity / Irrigation management / Supplemental irrigation / Crop ...
International Water Management Institute (IWMI) / Comprehensive Assessment of Water Management in Agriculture
core  

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

open access: yesMolecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton   +17 more
wiley   +1 more source

Ensuring Ethical Dental Care: Obtaining Legal Consent for Nonverbal Adults

open access: yesJournal of the California Dental Association, 2023
TDIC Risk Management Staff
doaj   +1 more source

Investigation of an outbreak of novel hepatitis of unknown aetiology in children and adolescents, Ireland, 2021 to 2023

open access: yesEurosurveillance
An outbreak of severe acute hepatitis of unknown aetiology in children (HUAC) was reported by the United Kingdom (UK) in spring 2022. Within days, a corresponding increase was identified in Ireland.
on behalf of the Incident Management Team
doaj   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

IWMI medium term plan 2010-2012 [PDF]

open access: yes
Research institutes / Strategy planning / Financial situation / Research priorities / Research projects / Project planning / Maintenance costs / Water resource management / Irrigated ...
International Water Management Institute (IWMI).
core  

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